Amy’s Stage 4 Hormone-Positive Lobular Breast Cancer Story

Patient Info: Amy, Female | Stage IV

Biomarkers: ER-positive; PR-positive; HER2-negative

Metastatic Site: Spine; pelvis

Amy was living with de novo stage 4 lobular breast cancer involving the spine and pelvis and remained active in rural-patient advocacy.

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Breast cancer treatment during pregnancy followed by postpartum targeted therapy

Patient Info: Anonymized, Female, Under 40 | Stage IV

She achieved a near-complete response after 4 cycles of docetaxel and then continued systemic treatment after delivery.

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Stage IIB triple-negative metaplastic breast cancer with early metastatic recurrence: durable response to pembrolizumab-based therapy

Patient Info: Anonymized, Female, 50s | Stage IV

Biomarkers: Triple-negative metaplastic breast cancer with PD-L1 CPS 83.2, BRCA1/2 negative

Metastatic Site: lung, sternum

As of May 2026, she had more than 30 months of disease control after pembrolizumab-based therapy for early recurrent metastatic metaplastic breast cancer, with only mild residual sternal uptake and no disease progression.

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My Metastatic Breast Cancer Spread To My BRAIN!

Patient Info: Anonymized, Female, 40s | Stage IV

Metastatic Site: brain

As of May 2026, the patient was living with metastatic breast cancer involving the brain, receiving 2 brain-directed chemotherapy infusions every 3 weeks, and describing the disease as chronic rather than a death sentence.

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Stage IV Breast Cancer: Gynna's Patient Story

Patient Info: Gynna, Female, Under 40 | Stage IV

Metastatic Site: Bone

As of May 2026, Gynna was living with Stage IV metastatic breast cancer in the bones; after progression in June 2025, she had a partial response by December 2025 and continued indefinite treatment.

I Lost My Wife To Metastatic Breast Cancer at 29 Years Old

Patient Info: Samantha, Female, Under 40 | Stage IV

Metastatic Site: rib/bone; lymph nodes; brain; liver

Samantha died from metastatic breast cancer in early January 2026 at age 29 after brain and liver progression, heart failure, and tumor lysis syndrome during her final hospitalization.

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Stage IV BRCA Breast Cancer: Maralee's Survivor Story

Patient Info: Maralee, Female, Under 40 | Stage IV

Biomarkers: BRCA mutation

Metastatic Site: Brain

As of May 2026, Maralee had no evidence of active disease after prior Stage IV breast cancer with brain metastasis, had stopped the PARP inhibitor after 2 years, remained without brain recurrence long enough to pursue pregnancy, and gave birth to a second daughter.

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Stage IV Breast Cancer: Elissa's Patient Story

Patient Info: Elissa Kalver, Female | Stage IV

As of April 2026, Elissa was described as a metastatic breast cancer thriver and founder of We Got This, with the episode focused on parenting, support needs, and practical help during life with metastatic breast cancer.

Stage IV HR-Positive Breast Cancer: Joelle's Patient Story

Patient Info: Joelle, Female, Under 40 | Stage IV

Biomarkers: HR-positive / hormone-positive

Metastatic Site: Bone/hip; lymph nodes; other sites not specified

Living with Stage IV hormone-positive breast cancer on ongoing systemic therapy and monitoring, with tumor-marker checks every 3 months and scans every 6 months; no remission or NED status is stated.

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Stage IV Breast Cancer: Erica's Patient Story

Patient Info: Erica, Female, 40s | Stage IV

Biomarkers: Hormone-positive; HER2-negative

Metastatic Site: Bone — ribs, sternum, spine, femur/right hip, shoulder…

Living with stable Stage IV hormone-positive, HER2-negative metastatic breast cancer involving multiple bones, currently managed with monthly hormone-suppressant injections and monitoring.

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Metastatic HER2-positive breast cancer complicated by severe low magnesium

Patient Info: Anonymized, Female, 50s | Stage IV

Biomarkers: HER2-positive

Metastatic Site: bone|lungs|liver|brain

She died during a hospitalization for advanced metastatic breast cancer and severe treatment-related hypomagnesemia, with her final care focused on comfort.

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Stage IV Breast Cancer: Lauren's Patient Story

Patient Info: Lauren Huffmaster, Female | Stage IV

As of March 2026, Lauren Huffmaster had been living with metastatic breast cancer since 2015 and had founded Adventure Therapy Foundation, using story work and support programs to help others with cancer.

Metastatic invasive lobular breast cancer with stomach, ovarian, peritoneal, rectal, and jejunal spread

Patient Info: Anonymized, Female, 40s | Stage IV

Biomarkers: Primary tumor and gastric metastasis were ER/PR positive and HER2 negative; GATA3 supported breast origin in the metastasis.

Metastatic Site: stomach; ovaries; peritoneum; rectum; jejunum

During 2025, she remained under active oncologic management for metastatic invasive lobular breast cancer with gastrointestinal, ovarian, peritoneal, rectal, and jejunal involvement.

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Stage IV HER2-Positive Breast Cancer: Christina's Patient Story

Patient Info: Christina, Female | Stage IV

Biomarkers: HER2-positive

Metastatic Site: Liver; lymph nodes

Christina was living with Stage IV HER2-positive metastatic breast cancer. Treatment had cleared the liver disease and removed the visible breast tumor, but small armpit lymph-node disease required radiation and she continued IV treatment every 3 weeks.

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ER-positive/HER2-positive breast cancer with rare paranasal sinus and skull metastasis

Patient Info: Anonymized, Female, 70+ | Stage IV

Biomarkers: Primary and paranasal sinus metastasis were ER positive, PR negative, HER2 positive; GATA3 supported breast origin in metastasis.

Metastatic Site: left frontal sinus; ethmoid air cells; posterior…

The paranasal sinus/skull metastasis did not respond to palliative radiotherapy; her condition deteriorated and she died 2 years after her initial presentation to the treating facility.

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Stage IV ER-positive/HER2-negative breast cancer with synchronous gastric and bone metastases

Patient Info: Anonymized, Female, 70+ | Stage IV

Biomarkers: Gastric metastasis showed ER-positive, PR-negative, HER2 0 lobular breast cancer. Breast primary was ER/PR-positive, HER2-negative

Metastatic Site: bone; stomach/gastric

At 2-month follow-up, upper-GI symptoms had improved, anastrozole plus palbociclib was tolerated, and CT showed stable disease with persistent diffuse osseous metastases; no further follow-up was available.

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Invasive lobular breast cancer with colonic metastases treated with colectomy and capecitabine

Patient Info: Anonymized, Female, 50s | Stage IV

Biomarkers: Breast and colon metastatic samples were ER+ and HER2-; PR varied by sample

Metastatic Site: colon; perivisceral lymph nodes

After laparoscopic left colectomy and capecitabine for colonic metastases, follow-up showed no clinical or radiological evidence of recurrence or progression at 8 months postoperatively.

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Stage 4 breast cancer: 4 years and counting

Patient Info: Anonymized, Female, 60s | Stage IV

Biomarkers: Initial tumor: hormone receptor-positive; HER2 1+. Metastatic recurrence: triple-negative breast cancer.

Metastatic Site: liver, bone, lung, supraclavicular lymph nodes,…

After response of choroidal metastases to eye radiation plus sacituzumab govitecan, disease progressed in February 2023 with cerebellar and pituitary brain lesions; she developed obstructive hydrocephalus, entered hospice in May 2023, and died in June 2023.

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Metastatic triple-negative breast cancer with sacituzumab-govitecan pneumonitis and progression

Patient Info: Anonymized, Female, 60s | Stage IV

Biomarkers: ER-negative; PR-negative; HER2-negative

Metastatic Site: lung

Sacituzumab-govitecan pneumonitis improved with corticosteroids and half-dose rechallenge did not reproduce pneumonitis, but follow-up CT showed one new pulmonary metastasis and enlargement of previous lung metastases; PFS on sacituzumab govitecan was 5.37 months.

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Stage IV HER2-Positive Breast Cancer: Sonja's Patient Story

Patient Info: Sonja Rideout, Female | Stage IV

Biomarkers: HER2-positive; Tempus testing later indicated immunotherapy as an option

Metastatic Site: Lungs; liver; bone: tailbone; thoracic lymph nodes

As of January 2026, Sonja was living with metastatic HER2-positive breast cancer after spread to lungs and liver, later tailbone and thoracic lymph nodes, and had moved to weekly carboplatin/gemcitabine plus monthly immunotherapy.

Stage IV triple-negative invasive lobular breast cancer with HER2 mutations: complete metabolic response to trastuzumab deruxtecan

Patient Info: Anonymized, Female, 70+ | Stage IV

Biomarkers: Triple-negative invasive lobular breast cancer with HER2-low/dubious staining and HER2 FISH-negative; somatic ERBB2/HER2 and mutations.

Metastatic Site: iliac bone lesions / bone metastases

As of January 2026, metastatic triple-negative invasive lobular breast cancer with HER2 mutations had a sustained complete metabolic response to trastuzumab deruxtecan for 20 months, with dose reduction for neutropenia and no pulmonary toxicity.

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Stage IV Breast Cancer: Lea's Patient Story

Patient Info: Lea, Female, Under 40 | Stage IV

Metastatic Site: Bone: hip sockets, femurs, spine; liver

As of January 2026, Lea was living with metastatic breast cancer involving bone and liver and was in active treatment with Taxol after progression changed her treatment plan.

Metastatic breast cancer history with pacing-induced cardiomyopathy and heart-function recovery

Patient Info: Anonymized, Female, 50s | Stage IV

Metastatic Site: sternum; ribs

She had osseous metastatic breast cancer involving the sternum and ribs, while pacing-induced cardiomyopathy improved clinically and biventricular function recovered completely at 6 months on medical therapy.

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Breast Cancer Discovered After Widespread Bone Metastases

Patient Info: Anonymized, female, 40s | Stage IV

Biomarkers: ER 90–95%; PR 90–95%; HER2 IHC 0; Ki-67 5%; germline BRCA1/2 negative

Metastatic Site: bone, bone marrow

She was receiving ongoing letrozole and ribociclib for Stage IV hormone receptor-positive, HER2-negative breast cancer with diffuse bone involvement.

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