A durable response to trastuzumab in heavily pretreated metastatic breast cancer

Patient Info: Anonymized, Female, 60s | Stage IV

Biomarkers: Initial tumor ER-positive and PR-positive. Metastatic liver biopsy ER-negative and PR-negative with HER2 IHC 1+ and nonamplified. Later biopsy ER and PR weakly positive at 5%–10%, HER2 IHC 1+ and nonamplified, and ERBB3 p. with evidence of HER2/HER3 pathway activation.

Metastatic Site: lungs; hilar and mediastinal lymph nodes; liver; bone

She had ongoing benefit for more than 10 months on trastuzumab and capecitabine, with improved symptoms, lower tumor markers, and a confirmed partial response.

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Stage IV Breast Cancer: Harper's Patient Story

Patient Info: Harper, Female, 50s | Stage IV

Harper was living with Stage IV breast cancer after self-funded private treatment that included mastectomy, lymphadenectomy, chemotherapy, and radiation therapy; she felt better than before diagnosis but still hoped for complete recovery.

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Breast Cancer: Luz's Survivor Story

Patient Info: Luz

Luz described her breast cancer as being in remission after mastectomy, lymph-node surgery, and chemotherapy, and she remained on hormone therapy.

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Stage II Breast Cancer: Hwee's Patient Story

Patient Info: Hwee Lin, Female, 60s | Stage II

Hwee Lin was receiving targeted therapy for Stage II breast cancer and described the treatment as effective while managing fatigue, hair loss, nausea, and vomiting with medication and improved nutrition.

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Breast Cancer: Vivienne's Survivor Story

Patient Info: Vivienne

Vivienne said she was in remission after completing most of her treatment and continued hormone therapy.

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Stage III Breast Cancer: Aurora's Patient Story

Patient Info: Aurora, Female, 40s | Stage III

Aurora was treated for Stage III breast cancer with mastectomy, lymphadenectomy, Cytoxan chemotherapy, and radiation therapy, then moved to chemotherapy alone after the initial plan was not working effectively.

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Stage II Breast Cancer: Ingrid's Patient Story

Patient Info: Ingrid | Stage II

Ingrid said her stage 2 breast cancer was in remission while she continued a low-toxicity systemic anticancer monotherapy.

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Stage III Breast Cancer: Kelly's Patient Story

Patient Info: Kelly, Female, 40s | Stage III

Kelly had Stage III breast cancer diagnosed around 2021, with treatment that included mastectomy, lymphadenectomy, chemotherapy, and radiation therapy; after a treatment change, she was still receiving radiation therapy.

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Stage III Breast Cancer: Beth's Survivor Story

Patient Info: Beth, Female, 40s | Stage III

As of 2021, Beth was in remission and no longer taking cancer medication after mastectomy, lymphadenectomy, chemotherapy, radiation therapy, and targeted therapy.

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Stage II HER2-Positive Breast Cancer: Kelsey's Survivor Story

Patient Info: Kelsey, Female, 40s | Stage II

Biomarkers: HER2-positive

Kelsey survived Stage II HER2-positive breast cancer after mastectomy, chemotherapy, and targeted therapy, with recovery supported by nutrition changes, massages, supplements, and support-group connection.

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Stage I HER2-Positive Breast Cancer: Betty's Survivor Story

Patient Info: Betty, Female, 50s | Stage I

Biomarkers: HER2-positive

As of 2021, Betty was in remission after mastectomy and chemotherapy with Herceptin, while managing side effects such as hair loss, peripheral neuropathy, and weight changes.

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Stage III Breast Cancer: Onagh's Survivor Story

Patient Info: Onagh, Female | Stage III

Her stage 3 breast cancer was in complete remission, and she no longer required treatment.

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Stage IV Breast Cancer: Rachael's Patient Story

Patient Info: Rachael | Stage IV

Rachael was living with stage 4 breast cancer after following a plan of mastectomy, chemotherapy, and radiation therapy.

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Ana's Stage 2 Breast Cancer and Cancer-Free Milestone

Patient Info: Ana, Female, 50s | Stage II

Ana completed intensive multimodal treatment and was declared cancer-free in 2024. She continued Tamoxifen as a planned 5-year hormone-therapy course.

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Breast Cancer: Maria's Patient Story

Patient Info: Maria

Maria underwent mastectomy, lymph-node surgery, chemotherapy, and radiation and continued to work through fear that the treatment might not succeed.

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Stage II Breast Cancer: Marisol's Survivor Story

Patient Info: Marisol | Stage II

Marisol said the breast cancer was in remission after completing most active treatment, and she continued hormone therapy.

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Stage II Breast Cancer: Sheryl's Patient Story

Patient Info: Sheryl | Stage II

Sheryl is currently receiving long-term hormone therapy and remains focused on becoming cancer-free.

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Stage II Breast Cancer: Erika's Patient Story

Patient Info: Erika, Female, 40s | Stage II

As of 2021, Erika was undergoing treatment for Stage II breast cancer and was on targeted therapy after mastectomy, lymphadenectomy, chemotherapy, and targeted therapy.

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Stage I Breast Cancer: Tia's Survivor Story

Patient Info: Tia | Stage I

More than 3 years after her Stage I diagnosis, Tia described herself as in remission and no longer taking medication for breast cancer.

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Stage II HR-Positive Breast Cancer: Faith's Survivor Story

Patient Info: Faith, Female, Under 40 | Stage II

Biomarkers: ER-positive; HER2-positive

Faith moved into survivorship after treatment for Stage II ER-positive, HER2-positive breast cancer, with ongoing fear of recurrence but renewed focus on family, nutrition, exercise, and work.

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Rare Tall Cell Breast Carcinoma Treated With Surgery Alone

Patient Info: Anonymized, female, 40s

Biomarkers: Weak ER and PR expression; HER2-negative; IDH2 mutation

No residual tumor or lymph-node involvement was found at completion surgery, PET-CT showed no metastases, and she remained disease-free 6 months after surgery.

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A Woman With Prior Breast Cancer Later Faced Metastatic Pancreatic Cancer and Recurrent Strokes

Patient Info: Anonymized, Female, 60s

Her breast cancer had previously been treated with mastectomy and adjuvant chemotherapy before a later hospitalization centered on metastatic pancreatic cancer and recurrent embolic strokes.

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Stage III Invasive Lobular Carcinoma: Barb's Survivor Story

Patient Info: Barb, Female | Stage III

As of December 2020, Barb was in survivorship after bilateral mastectomy, chemotherapy, radiation, and 2 reconstruction revision surgeries for Stage III invasive lobular breast cancer.

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Breast Adenoid Cystic Carcinoma That Later Spread to Bone and Lung

Patient Info: Anonymized, Female | Stage Metastatic/Advanced

Metastatic Site: bone|lungs

Bone and lung metastases were detected in the fourth year after surgery.

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