Targeted treatment for an 89-year-old woman with Stage IV HRD-positive ovarian cancer

Patient Info: Anonymized, Female, 70+ | Stage IV

Biomarkers: HRD-positive; germline BRCA2 pathogenic variant

Follow-up imaging showed a partial response, tumor markers improved, and she remained on treatment with better appetite and general condition at 7 months.

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Stage IV HER2-Positive Invasive Ductal Carcinoma: Renee's Patient Story

Patient Info: Renee N., Female | Stage IV

Biomarkers: HER2-positive

Metastatic Site: Brain

As of June 2026, Renee’s public story described living with metastatic HER2-positive breast cancer as a chronic illness, after brain radiation and while on Kadcyla every 3 weeks with stable scans reported in December 2019 and early March 2020.

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Stage IVA lung squamous cell carcinoma with immune-checkpoint-inhibitor-associated Graves thyroid storm

Patient Info: Anonymized, Male | Stage IV

Biomarkers: Cancer biomarkers not reported. Thyroid storm workup had TSAb/TRAb positivity consistent with Graves disease.

Metastatic Site: not specified in extracted case text

After thyroid storm improved with antithyroid therapy and supportive care, the patient was transferred for further lung-cancer treatment but died of progressive lung cancer about 2 months later.

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Stage IV ALK Lung Cancer: Nancee's Patient Story

Patient Info: Nancee Pronsati, Female | Stage IV

Biomarkers: ALK-positive; ALK fusion/rearrangement

Metastatic Site: bilateral lung nodules, brain

As of May 2026, Nancee had lived about 10 years with metastatic ALK-positive lung cancer, including brain progression, and continued long-term targeted therapy with quality of life as a major goal.

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Stage IV Colorectal Cancer: Ken's Patient Story

Patient Info: Ken, Male, 50s | Stage IV

Metastatic Site: Liver

As of May 2026, Ken was more than 3 years into Stage IV colorectal cancer. He was not cancer-free or NED, but described the disease as minimal and manageable with surveillance, maintenance chemotherapy/targeted therapy, and occasional ablation.

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Stage IV Non-Small Cell Lung Cancer: Jill's Patient Story

Patient Info: Jill, Female, 50s | Stage IV

Biomarkers: Driver mutation identified; specific mutation not stated

Metastatic Site: pleura

As of May 2026, Jill had lived 17 years with NSCLC, later experienced pleural metastases/progression, and remained on biomarker-guided targeted therapy with chemotherapy added.

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EGFR-mutated lung cancer responds after acquired ROS1 resistance

Patient Info: Anonymized, Female, 50s | Stage IV

Biomarkers: EGFR L858R mutation; acquired ROS1 rearrangement

Metastatic Site: pleura

She remained on osimertinib plus crizotinib with a sustained clinical and radiologic response for more than 18 months.

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Stage IV EGFR-mutated lung cancer responds after targeted therapy intolerance

Patient Info: Anonymized, Female, 50s | Stage IV

Biomarkers: EGFR L858R mutation; PIK3CA E545K mutation; acquired ROS1 rearrangement

Metastatic Site: pleura|pericardium|bone|lungs

Chemotherapy produced a partial response that remained sustained for 7 months at the latest follow-up.

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EGFR-mutated Stage IV lung cancer with later brain progression

Patient Info: Anonymized, Female, 60s | Stage IV

Biomarkers: EGFR exon 19 deletion; acquired EGFR C797S mutation; acquired ROS1 rearrangement

Metastatic Site: brain|bone

She died about 20 months after diagnosis after brain progression and a severe postoperative stroke.

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Stage IV Colorectal Cancer: Carrie's Patient Story

Patient Info: Carrie, Female | Stage IV

Metastatic Site: ovaries; uterus; retroperitoneal/behind-kidney tumor

As of May 2026, Carrie had recurrent Stage IV signet ring cell colon cancer after a prior no-evidence-of-disease period and was receiving more aggressive chemotherapy plus radiation after surgery for a tumor behind the kidney.

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Stage IV rectal mucinous adenocarcinoma with pancreatic metastasis: response to chemotherapy and staged surgery

Patient Info: Anonymized, Male, 70+ | Stage IV

Biomarkers: CA 19-9 93.4 U/mL; CEA 3.4 ng/mL; pancreatic lesion biopsy consistent with colorectal origin

Metastatic Site: pancreas

As of May 2026, he had good clinical progress during 5 months of follow-up after staged treatment, including chemoradiation, FOLFOX, abdominoperineal resection, FOLFIRINOX, and Whipple resection of the pancreatic metastasis.

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Amy’s Stage 4 Hormone-Positive Lobular Breast Cancer Story

Patient Info: Amy, Female | Stage IV

Biomarkers: ER-positive; PR-positive; HER2-negative

Metastatic Site: Spine; pelvis

Amy was living with de novo stage 4 lobular breast cancer involving the spine and pelvis and remained active in rural-patient advocacy.

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Rectal cancer that spread through the lungs: complete remission after BRAF-targeted therapy

Patient Info: Anonymized, Female, Under 40 | Stage IV

Biomarkers: BRAF mutation; HER2-negative; microsatellite stable; no detectable KRAS or NRAS mutations

Metastatic Site: lungs (pulmonary lymphangitic carcinomatosis);…

After progression with recurrent lung metastases and a new pericardial effusion, she chose hospice care and died in February 2025, 19 months after diagnosis.

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Metastatic triple-negative breast cancer with orbital and bone metastases responding to nab-paclitaxel plus everolimus

Patient Info: Anonymized, Female, 70+ | Stage IV

Biomarkers: Primary breast cancer was ER-low, PR/HER2 negative. Orbital metastasis was triple-negative with AKT1 exon 4 mutation.

Metastatic Site: right orbit/orbital mass; bone

At 6-month follow-up, systemic disease was stable, ocular symptoms had significantly improved, orbital metastases were stable on MRI, and the response was described as RECIST partial response/progression-free interval while treatment continued.

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Breast cancer treatment during pregnancy followed by postpartum targeted therapy

Patient Info: Anonymized, Female, Under 40 | Stage IV

She achieved a near-complete response after 4 cycles of docetaxel and then continued systemic treatment after delivery.

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Stage IIB triple-negative metaplastic breast cancer with early metastatic recurrence: durable response to pembrolizumab-based therapy

Patient Info: Anonymized, Female, 50s | Stage IV

Biomarkers: Triple-negative metaplastic breast cancer with PD-L1 CPS 83.2, BRCA1/2 negative

Metastatic Site: lung, sternum

As of May 2026, she had more than 30 months of disease control after pembrolizumab-based therapy for early recurrent metastatic metaplastic breast cancer, with only mild residual sternal uptake and no disease progression.

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My Metastatic Breast Cancer Spread To My BRAIN!

Patient Info: Anonymized, Female, 40s | Stage IV

Metastatic Site: brain

As of May 2026, the patient was living with metastatic breast cancer involving the brain, receiving 2 brain-directed chemotherapy infusions every 3 weeks, and describing the disease as chronic rather than a death sentence.

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Stage IV Colorectal Adenocarcinoma: Miles's Patient Story

Patient Info: Miles, Male, Under 40 | Stage IV

Metastatic Site: abdomen

Miles died on November 1, 2024, at age 23 after an 8-month medical journey. A private autopsy after his death revealed widespread metastatic colon adenocarcinoma with signet ring cells throughout his abdomen.

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Stage IV ALK Lung Cancer: Jake's Patient Story

Patient Info: Jake, Male, Under 40 | Stage IV

Biomarkers: ALK-positive mutation

Metastatic Site: brain; lung; ankle bone

As of May 2026, Jake was 28 and had lived more than 13 years with Stage IV ALK-positive lung cancer, with ongoing treatment history including targeted therapy, surgeries, radiation, clinical-trial therapy, and recent chemotherapy.

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Stage IV Breast Cancer: Gynna's Patient Story

Patient Info: Gynna, Female, Under 40 | Stage IV

Metastatic Site: Bone

As of May 2026, Gynna was living with Stage IV metastatic breast cancer in the bones; after progression in June 2025, she had a partial response by December 2025 and continued indefinite treatment.

Stage IV Colorectal Cancer: Lawrence's Survivor Story

Patient Info: Lawrence Henry, Male, 50s | Stage IV

Metastatic Site: Lung; abdominal lymph nodes

As of May 2026, Lawrence had no evidence of disease on scans since November, no blood-test signs of recurrence, was off colon cancer treatment, and returned to UT MD Anderson every 3 months for checkups.

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More than 5 years of disease control with maintenance chemotherapy for Stage IV lung cancer

Patient Info: Anonymized, Male | Stage IV

Biomarkers: KRAS mutation; TP53 mutation

Metastatic Site: brain

After more than 60 months of follow-up and prolonged maintenance chemotherapy, the latest assessment found no evidence of current tumor progression.

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Stage IV Ovarian Cancer First Found Through an Umbilical Metastasis

Patient Info: Anonymized, female, 60s | Stage IV

Biomarkers: WT1-positive; CK7-positive; CA-125 321 U/mL at diagnosis

Metastatic Site: umbilicus

After 9 months of bevacizumab maintenance, her clinical and imaging findings remained stable.

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I Lost My Wife To Metastatic Breast Cancer at 29 Years Old

Patient Info: Samantha, Female, Under 40 | Stage IV

Metastatic Site: rib/bone; lymph nodes; brain; liver

Samantha died from metastatic breast cancer in early January 2026 at age 29 after brain and liver progression, heart failure, and tumor lysis syndrome during her final hospitalization.

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