Stage IV Colorectal Cancer: David's Survivor Story

Patient Info: David, Male, Under 40 | Stage IV

Metastatic Site: Liver; lymph nodes near the heart

As of March 2026, David showed no evidence of cancer after Stage IV colorectal cancer with liver and near-heart lymph node metastases, following chemotherapy, tumor and lymph-node surgery, liver-directed radiation, radioembolization, and liver transplant.

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Stage IV Colorectal Cancer: Joe's Patient Story

Patient Info: Joe, Male | Stage IV

Biomarkers: Specific biomarkers not reported

Metastatic Site: Liver; lymph nodes; lungs

Stage IV colon cancer initially reached no evidence of disease after FOLFOX plus panitumumab, but later recurred in the liver and lymph nodes, progressed to the lungs, and did not respond to later FOLFOX rechallenge or FOLFIRI before he started an immunotherapy clinical trial.

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Stage IV Colorectal Cancer: Alyssa's Patient Story

Patient Info: Alyssa Kelly, Female, Under 40 | Stage IV

Metastatic Site: Liver; lung

More than 4 years after pregnancy-associated Stage IV colorectal cancer, Alyssa was alive with her son, but after more than 1 year off chemotherapy she had several lung tumors, restarted chemotherapy, and was looking into clinical trials.

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Metastatic invasive lobular breast cancer with stomach, ovarian, peritoneal, rectal, and jejunal spread

Patient Info: Anonymized, Female, 40s | Stage IV

Biomarkers: Primary tumor and gastric metastasis were ER/PR positive and HER2 negative; GATA3 supported breast origin in the metastasis.

Metastatic Site: stomach; ovaries; peritoneum; rectum; jejunum

During 2025, she remained under active oncologic management for metastatic invasive lobular breast cancer with gastrointestinal, ovarian, peritoneal, rectal, and jejunal involvement.

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Stage IV Non-Small Cell Lung Cancer: Natalie's Patient Story

Patient Info: Natalie, Female, Under 40 | Stage IV

Metastatic Site: Spine

Natalie was living with Stage IV NSCLC after a double lung transplant gave her new lung function, but cancer later appeared in the spine and required renewed chemotherapy and radiation.

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Stage IV HER2-Positive Breast Cancer: Christina's Patient Story

Patient Info: Christina, Female | Stage IV

Biomarkers: HER2-positive

Metastatic Site: Liver; lymph nodes

Christina was living with Stage IV HER2-positive metastatic breast cancer. Treatment had cleared the liver disease and removed the visible breast tumor, but small armpit lymph-node disease required radiation and she continued IV treatment every 3 weeks.

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ER-positive/HER2-positive breast cancer with rare paranasal sinus and skull metastasis

Patient Info: Anonymized, Female, 70+ | Stage IV

Biomarkers: Primary and paranasal sinus metastasis were ER positive, PR negative, HER2 positive; GATA3 supported breast origin in metastasis.

Metastatic Site: left frontal sinus; ethmoid air cells; posterior…

The paranasal sinus/skull metastasis did not respond to palliative radiotherapy; her condition deteriorated and she died 2 years after her initial presentation to the treating facility.

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Stage IV Colorectal Cancer: Mike's Patient Story

Patient Info: Mike Ray, Male, Under 40 | Stage IV

Biomarkers: Lynch syndrome

Metastatic Site: Liver

As of March 2026, Mike had recovered quickly from a May 2025 liver transplant after about 2.5 years of cancer-control treatment for liver-metastatic colon cancer with Lynch syndrome, and he had returned to running, weight training, and triathlon goals.

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Severe skin reaction after immunotherapy for metastatic gastric cancer

Patient Info: Anonymized, Male, 60s | Stage IV

Biomarkers: pMMR; PD-L1 CPS ~10; HER2 1+

Metastatic Site: liver

He recovered from the severe treatment-related skin reaction and was discharged after 32 days, with sintilimab permanently discontinued.

PubMed CentralRead more →

Stage IV EGFR-positive lung cancer treated for nearly 5 years before progression

Patient Info: Anonymized, Male, 70+ | Stage IV

Biomarkers: EGFR L858R mutation

Metastatic Site: liver

The cancer later progressed despite chemotherapy, and he died from lung cancer 4 years and 8 months after diagnosis.

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Three years without recurrence after intensive treatment for recurrent rectal cancer

Patient Info: Anonymized, Female, 50s | Stage IV

Biomarkers: pMMR; KRAS mutation; BRAF wild-type

Metastatic Site: peritoneum

No recurrence had been detected 3 years after the extensive surgery and intraoperative treatments.

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Stage IV small-cell lung cancer with hepatic metastases: serplulimab stopped after VKH-like uveitis

Patient Info: Anonymized, Male, 70+ | Stage IV

Biomarkers: No molecular biomarkers reported

Metastatic Site: liver

Serplulimab was discontinued after VKH-like uveitis; oral prednisone improved vision, but the case did not report a definitive cancer-response outcome after immunotherapy interruption.

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Stage IV EGFR Non-Small Cell Lung Cancer: Maggie's Patient Story

Patient Info: Maggie, Female, 60s | Stage IV

Biomarkers: EGFR mutation; MET amplification resistance mutation; MET overexpression

Metastatic Site: Brain

Maggie initially reached no evidence of disease on EGFR-targeted therapy, but later had repeated progression, including MET-amplification resistance and MET overexpression, requiring SBRT, a clinical trial, chemotherapy, and later-line targeted treatment.

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Stage IV Colorectal Cancer: Natasha's Patient Story

Patient Info: Natasha McCants, Female, 40s | Stage IV

Biomarkers: Unspecified tumor mutation identified by molecular testing

Metastatic Site: Liver; lungs; ovary

As of February 2026, Natasha’s Stage IV colorectal cancer was under control after mutation-informed treatment at City of Hope, but Signatera showed potentially active cells and she remained on daily chemotherapy pills.

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Stage IV Colorectal Cancer: Sydney's Patient Story

Patient Info: Sydney, Female | Stage IV

Metastatic Site: Liver; lungs

Sydney was living with Stage IV colorectal cancer involving the liver and lungs. After multiple lines of treatment, she had a new liver spot and was back on lower-dose FOLFIRI every other Tuesday with a 46-hour pump.

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Stage IV ALK Non-Small Cell Lung Cancer: Clara's Patient Story

Patient Info: Clara, Female, Under 40 | Stage IV

Biomarkers: ALK-positive / ALK-rearranged after repeat Tempus testing

Metastatic Site: Pelvis; spleen

As of February 2026, ALK-targeted therapy had improved Clara’s symptoms enough that she no longer needed a walker or cane, and upcoming scans would determine whether pelvic tumor surgery remained an option.

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Stage IV pleomorphic lung cancer complicated by esophageal invasion and severe infection

Patient Info: Anonymized, Male, 70+ | Stage IV

Biomarkers: BRAF ; PD-L1 high

Metastatic Site: pleura|peritoneum|bone

He died 21 days after admission from respiratory failure caused by advanced lung cancer complicated by severe infection and aspiration.

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Complete response in Stage IV gastric cancer after chemotherapy, immunotherapy, and surgery

Patient Info: Anonymized, Male, 60s | Stage IV

Biomarkers: HER2-negative; MSS; PD-L1 high

Metastatic Site: liver

He achieved a complete pathologic response and remained free of recurrence for 3 years and 3 months after surgery.

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Stage IV ER-positive/HER2-negative breast cancer with synchronous gastric and bone metastases

Patient Info: Anonymized, Female, 70+ | Stage IV

Biomarkers: Gastric metastasis showed ER-positive, PR-negative, HER2 0 lobular breast cancer. Breast primary was ER/PR-positive, HER2-negative

Metastatic Site: bone; stomach/gastric

At 2-month follow-up, upper-GI symptoms had improved, anastrozole plus palbociclib was tolerated, and CT showed stable disease with persistent diffuse osseous metastases; no further follow-up was available.

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Stage IVB lung adenocarcinoma with severe immune-related complications

Patient Info: Anonymized, Male, 70+ | Stage IV

Biomarkers: PD-L1 TPS 20%; BRAF mutation

Metastatic Site: left supraclavicular fossa, left axilla, right hilum,…

The patient had an initial partial response to ipilimumab/nivolumab but developed severe immune-related pneumonitis, thrombocytopenia, and aplastic anemia. Cytopenias recovered with eltrombopag, but lung cancer later relapsed with carcinomatous meningitis, and he died 20 months after diagnosis.

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Stage IV ROS1 Lung Cancer: Phil's Patient Story

Patient Info: Phil, Male, 60s | Stage IV

Biomarkers: ROS1 mutation

Metastatic Site: Lymph nodes; other lung

Phil was living with incurable Stage IV ROS1-positive lung cancer. After initial chemotherapy, a ROS1-targeted pill worked for about 2 years, and he later continued on a Mass General clinical-trial treatment with follow-up every 3 months.

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Invasive lobular breast cancer with colonic metastases treated with colectomy and capecitabine

Patient Info: Anonymized, Female, 50s | Stage IV

Biomarkers: Breast and colon metastatic samples were ER+ and HER2-; PR varied by sample

Metastatic Site: colon; perivisceral lymph nodes

After laparoscopic left colectomy and capecitabine for colonic metastases, follow-up showed no clinical or radiological evidence of recurrence or progression at 8 months postoperatively.

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Stage IV ALK Non-Small Cell Lung Cancer: Stephanie's Patient Story

Patient Info: Stephanie, Female, 40s | Stage IV

Biomarkers: ALK mutation / ALK-positive

Metastatic Site: ovaries; spine; liver; lung

Stage IV ALK-positive NSCLC is being managed with ALK-directed treatment; follow-up scans were described as improving, but the source does not state complete remission.

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Joe Carr

Patient Info: Joe Carr | Stage IV

Metastatic Site: liver, lungs

After about 2.5 years of chemotherapy and radiation, Joe had progression in his liver and lungs and was preparing to move into a clinical trial.

Fight Colorectal CancerRead more →