Stage IV gastric adenocarcinoma causes inferior vena cava compression and severe leg swelling

Patient Info: Anonymized, Female, 50s | Stage IV

Biomarkers: HER2-positive

Metastatic Site: omentum

At the latest follow-up, she was receiving cycle 5 of paclitaxel and trastuzumab. Her appetite, energy and leg edema had improved, although abdominal bloating persisted.

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Severe gastrointestinal bleeding and perforation during apatinib treatment for metastatic gastric cancer

Patient Info: Anonymized, Female, 50s | Stage IV

Biomarkers: HER2 IHC 2+; FISH negative for HER2 amplification

Metastatic Site: peritoneum, ileum

She died on February 23, 2015 after gastrointestinal perforation, septic shock and multiple organ dysfunction during progressive metastatic disease.

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Metastatic Low-Grade Serous Ovarian Cancer Causing Severe Pulmonary Hypertension

Patient Info: Anonymized, female, 70+ | Stage IV

Metastatic Site: pleura, pulmonary arteries

She died on hospital day 29 after rapidly progressive pulmonary hypertension. Autopsy attributed the pulmonary hypertension to metastatic ovarian serous carcinoma with pulmonary arterial tumor emboli.

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Metachronous gastric adenosquamous carcinoma spreads to the liver after endoscopic resection

Patient Info: Anonymized, Male, 70+ | Stage IV

Metastatic Site: liver

He died from gastric cancer 27 months after endoscopic resection of the metachronous adenosquamous carcinoma.

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Stage IV Colorectal Cancer: Dawn's Survivor Story

Patient Info: Dawn Eicher, Female, Under 40 | Stage IV

Metastatic Site: liver

After treatment for Stage IV colorectal cancer and a later recurrence, Dawn had 2 consecutive scans showing no evidence of disease and had been cancer-free for 8 months.

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Gastric signet-ring cell adenocarcinoma spreads to the urinary bladder

Patient Info: Anonymized, Male, 60s | Stage IV

Metastatic Site: urinary bladder

At the latest documentation, palliative chemotherapy had been started for metastatic gastric cancer involving the urinary bladder.

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Stage IV Breast Cancer: Liu's Patient Story

Patient Info: Liu Jing | Stage IV

More than eight years after a stage 4 diagnosis, Liu Jing remained on hormone and targeted therapies and continued working, walking, and mountain hiking.

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Stage IV signet-ring gastric cancer first presents with painful skeletal muscle metastases

Patient Info: Anonymized, Male, 60s | Stage IV

Metastatic Site: skeletal muscle

He died of progressive gastric cancer in June 2013, about 3 months after presentation.

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Stage IV gastric adenocarcinoma presents with nonbacterial thrombotic endocarditis and stroke

Patient Info: Anonymized, Male, Under 40 | Stage IV

Metastatic Site: omentum, peritoneum

He remained on anticoagulation for nonbacterial thrombotic endocarditis and was being followed by oncology for chemotherapy.

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Ovarian Cancer Recurs as a Solitary Splenic Metastasis Six Years Later

Patient Info: Anonymized, female, 50s | Stage IV

Metastatic Site: spleen

After removal of the solitary splenic metastasis, she returned to gynecologic oncology and received another course of paclitaxel and carboplatin.

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Gastric cancer recurs in the spermatic cord 7 years after treatment

Patient Info: Anonymized, Male, 40s | Stage IV

Metastatic Site: epididymis, spermatic cord

At 26 months after orchiectomy, he was doing well with no evidence of recurrence, more than 9 years after his original gastric-cancer surgery.

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Gastric cancer recurs in the spermatic cord after 6 years without recurrence

Patient Info: Anonymized, Male, 60s | Stage IV

Metastatic Site: spermatic cord

At 20 months after orchiectomy, he was stable with no recurrence, more than 7 years after treatment of his original gastric cancer.

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Gastric adenocarcinoma recurs in the adrenal gland 6 years after gastrectomy

Patient Info: Anonymized, Male, 50s | Stage IV

Metastatic Site: left adrenal gland

At 13 months after resection of the adrenal metastasis, imaging and tumor-marker follow-up found no evidence of recurrence, placing him more than 7 years beyond the original gastrectomy.

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Signet-ring gastric cancer with repeated recurrences and a late adrenal metastasis

Patient Info: Anonymized, Female, 40s | Stage IV

Metastatic Site: left adrenal gland

At 12 months after resection of the adrenal metastasis, no definite recurrence was found, roughly 7 years after the original gastric-cancer surgery.

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Metastatic gastric adenocarcinoma presents with Wernicke encephalopathy in a 35-year-old man

Patient Info: Anonymized, Male, Under 40 | Stage IV

Metastatic Site: liver

A 35-year-old man with vomiting, malnutrition and acute neurologic symptoms was diagnosed with Stage IV gastric adenocarcinoma with liver metastases and Wernicke encephalopathy.

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The Loss of a Mother

Patient Info: Anonymized, Female | Stage IV

She died in February 2013 after living with Stage IV gastric cancer while her daughter cared for her through treatment.

EGFR exon 19 lung adenocarcinoma with bone and brain metastases: brain lesions resolved on gefitinib

Patient Info: Anonymized, Male, 60s | Stage IV

Biomarkers: EGFR exon 19 deletion

Metastatic Site: lumbar spine, pelvic bone, brain (left occipital lobe,…

As of March 2014, asymptomatic brain metastases had regressed after 1 month of gefitinib and were no longer discernible after another 3 months, while lumbar vertebral disease was treated with radiotherapy.

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Stage IV NSCLC: near-complete response despite severe docetaxel-induced diarrhea

Patient Info: Anonymized, Male, 70+ | Stage IV

As of October 2013, he had completed 6 cycles of weekly docetaxel-cisplatin with dose reduction and supportive care, resulting in a near-complete response.

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Stage IV Ovarian Cancer: Bre's Patient Story

Patient Info: Bre Tipps, female, Under 40 | Stage IV

A recent CT scan showed the remaining tumors calcifying and dying during hormonal therapy, although the patient expected to need ongoing ovarian cancer treatment.

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Stage IV primary gastric choriocarcinoma reaches 9 years with no evidence of disease

Patient Info: Anonymized, Female, 60s | Stage IV

Metastatic Site: liver, lungs

She remained alive with no evidence of disease for 9 years after radiofrequency ablation, more than 9 years after the original diagnosis.

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Early gastric cancer returns in bone after an 8-year disease-free interval

Patient Info: Anonymized, Male, 50s | Stage IV

Metastatic Site: bone

After an 8-year disease-free interval, he developed bone metastasis, received chemotherapy, developed disseminated intravascular coagulopathy and died in August 2011, nearly 10 years after the original diagnosis.

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Ovarian Granulosa Cell Tumor Spreads to the Spine and Kidney

Patient Info: Anonymized, female, 40s | Stage IV

Metastatic Site: spine, kidney

Years after the original ovarian tumor, metastatic granulosa cell tumor was confirmed in the L1 vertebra and later in the left kidney.

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Gastric adenocarcinoma spreads to the liver and esophageal mucosa

Patient Info: Anonymized, Male, 60s | Stage IV

Metastatic Site: liver, esophageal mucosa

The metastatic disease progressed despite 3 cycles of second-line docetaxel plus cisplatin.

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Stage IV ER/PR-positive mucinous breast cancer: long-term no evidence of disease after surgery, AFTV, radiation, CEF, and endocrine therapy

Patient Info: Anonymized, Female, 50s | Stage IV

Biomarkers: ER-positive; PR-positive; delayed-type hypersensitivity to AFTV became pseudo-positive after vaccination and remained pseudo-positive 5.4 years later

Metastatic Site: Th7 vertebra

More than 6 years after primary surgery, she remained well with no evidence of vertebral metastasis activity, new metastasis, or local recurrence.

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