Stage I Breast Cancer: Tina's Patient Story

Patient Info: Tina | Stage I

Tina described herself as still fighting Stage I breast cancer after lumpectomy and chemotherapy.

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NRG1-Fusion Lung Cancer With a 24-Month Response to Afatinib

Patient Info: Anonymized, Female, 50s | Stage Metastatic/Advanced

Biomarkers: NRG1 fusion; KRAS/EGFR/ALK/ROS1/ERBB2 alterations not detected

Metastatic Site: left lung

Her cancer progressed during atezolizumab, and she died in May 2019.

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Stage III Colorectal Cancer: Hilmi's Patient Story

Patient Info: Hilmi | Stage III

Hilmi was still undergoing chemotherapy and remained focused on recovery while managing a stoma and treatment side effects.

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Recurrent NRG1-Fusion Lung Cancer After Surgery and Immunotherapy

Patient Info: Anonymized, Male, 60s | Stage Metastatic/Advanced

Biomarkers: SDC4-NRG1 fusion

He chose no further treatment after rapid progression on afatinib and died shortly afterward in hospice.

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Stage III Colorectal Cancer: Kenneth's Patient Story

Patient Info: Kenneth | Stage III

About 2 years after diagnosis, Kenneth was still undergoing treatment for Stage III colorectal cancer in late 2023.

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Stage II Breast Cancer: Ingrid's Patient Story

Patient Info: Ingrid | Stage II

Ingrid said her stage 2 breast cancer was in remission while she continued a low-toxicity systemic anticancer monotherapy.

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Colon Cancer With an MLH1 Deletion and Lynch Syndrome

Patient Info: Anonymized, Male, Under 40 | Stage III

Biomarkers: dMMR with loss of MLH1 and PMS2. Familial MLH1 c.1057_1060delGCTG frameshift deletion identified; its clinical significance had not previously been reported.

The colon cancer progressed rapidly despite postoperative and second-line therapy, and he died from multiple organ failure one week after pembrolizumab was started.

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Stage IV Mucinous Lung Cancer Treated With Afatinib and Surgery

Patient Info: Anonymized, Female, 40s | Stage IV

Biomarkers: CD74-NRG1 fusion; ALK/ROS1/EGFR/BRAF/KRAS/MET/HER2 wild type; PD-L1 initially not expressed and later 0%-20%

Metastatic Site: bilateral lungs|bone|right adrenal gland

She was alive and receiving treatment after bone and right-adrenal progression at the latest follow-up.

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Stage IV Colorectal Adenocarcinoma: Kyle's Survivor Story

Patient Info: Kyle, Under 40 | Stage IV

Kyle was 19 months NED and off treatment after Stage IV colon adenocarcinoma, following about 30 months of chemotherapy and targeted therapy.

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Stage II Breast Cancer: Shamala's Survivor Story

Patient Info: Shamala | Stage II

Shamala says she is free of cancer and in remission after treatment.

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Recurrent Mucinous Lung Cancer With Dose-Dependent Afatinib Responses

Patient Info: Anonymized, Female, Under 40 | Stage Metastatic/Advanced

Biomarkers: SDC4-NRG1 fusion; PD-L1 not expressed; low tumor mutation burden

Metastatic Site: bilateral lungs

She had progressive lung disease after several targeted-treatment attempts and was receiving paclitaxel with bevacizumab as of February 2020.

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Stage II Colorectal Adenocarcinoma: Laura's Survivor Story

Patient Info: Laura | Stage II

Laura was declared cancer-free in 2025 after 2 surgeries for Stage II rectal adenocarcinoma.

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Nearly 5 years without rectal cancer recurrence when a lung nodule proved to be infection

Patient Info: Anonymized, Male, 60s

He remained without rectal-cancer recurrence for nearly 5 years after diagnosis. A new lung nodule found in 2020 was surgically biopsied and proved to be Pneumocystis infection rather than metastasis or a new lung cancer.

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Metastatic Right-Sided Colon Cancer With an NRG1 Fusion

Patient Info: Anonymized, Male, 60s | Stage IV

Biomarkers: KRAS mutation; POMK-NRG1 fusion

Metastatic Site: liver|lungs

He had persistent metastatic disease after 16 months of afatinib and entered a phase I trial in January 2020.

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Stage I Colorectal Cancer: Mel's Survivor Story

Patient Info: Mel | Stage I

Cancer-free after partial colectomy and continued recovery after choosing not to receive chemotherapy.

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Stage III Breast Cancer: Kelly's Patient Story

Patient Info: Kelly, Female, 40s | Stage III

Kelly had Stage III breast cancer diagnosed around 2021, with treatment that included mastectomy, lymphadenectomy, chemotherapy, and radiation therapy; after a treatment change, she was still receiving radiation therapy.

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Stage I Breast Cancer: Melissa's Patient Story

Patient Info: Melissa | Stage I

Melissa was in remission and continued hormone therapy while managing fear of recurrence.

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Breast Cancer: Vivienne's Survivor Story

Patient Info: Vivienne

Vivienne said she was in remission after completing most of her treatment and continued hormone therapy.

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Stage II Breast Cancer: Erika's Patient Story

Patient Info: Erika, Female, 40s | Stage II

As of 2021, Erika was undergoing treatment for Stage II breast cancer and was on targeted therapy after mastectomy, lymphadenectomy, chemotherapy, and targeted therapy.

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Stage II HER2-Positive Breast Cancer: Kelsey's Survivor Story

Patient Info: Kelsey, Female, 40s | Stage II

Biomarkers: HER2-positive

Kelsey survived Stage II HER2-positive breast cancer after mastectomy, chemotherapy, and targeted therapy, with recovery supported by nutrition changes, massages, supplements, and support-group connection.

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Stage II Gastric Cancer: Andy's Patient Story

Patient Info: Andy | Stage II

Andy was still undergoing treatment and reported that targeted therapy was the current treatment.

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Stage III Breast Cancer: Aurora's Patient Story

Patient Info: Aurora, Female, 40s | Stage III

Aurora was treated for Stage III breast cancer with mastectomy, lymphadenectomy, Cytoxan chemotherapy, and radiation therapy, then moved to chemotherapy alone after the initial plan was not working effectively.

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Stage I Breast Cancer: Stella's Patient Story

Patient Info: Stella | Stage I

She is in remission after surgery and chemotherapy and remains on hormone therapy.

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Stage II HR-Positive Breast Cancer: Faith's Survivor Story

Patient Info: Faith, Female, Under 40 | Stage II

Biomarkers: ER-positive; HER2-positive

Faith moved into survivorship after treatment for Stage II ER-positive, HER2-positive breast cancer, with ongoing fear of recurrence but renewed focus on family, nutrition, exercise, and work.

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