Stage III Ovarian Cancer: Rachel's Patient Story

Patient Info: Rachel, female, Under 40 | Stage III

Biomarkers: CEA 125 reported as 1800

After surgery, Rachel learned she had Stage III ovarian cancer and was beginning to process the diagnosis with her family.

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Stage IV Colorectal Cancer: Monica's Patient Story

Patient Info: Monica, Female, Under 40 | Stage IV

Metastatic Site: lymph nodes

As of November 2024, Monica was still in active treatment, but lymph nodes had shrunk after chemotherapy and further surgery plus additional chemotherapy were planned.

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Rectal cancer surgery in a man with situs inversus and prior major stroke

Patient Info: Anonymized, Male, 60s

He recovered from surgery and had no tumor recurrence or metastasis during 24 months of follow-up.

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Stage IV Breast Cancer: Nina's Survivor Story

Patient Info: Nina, Female, Under 40 | Stage IV

Metastatic Site: Spine

As of November 2024, Nina had Stage IV metastatic breast cancer with prior spine metastasis, remained on indefinite infusions and medications, and had current scans showing no evidence of disease.

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Jazz: Stage III / borderline Stage IV colorectal cancer

Patient Info: Jazz, Male | Stage III

As of November 2024, Jazz was in active treatment for Stage III / borderline Stage IV colorectal cancer after colostomy surgery, chemotherapy, stomach tumor removal, and radiation, with surgery still planned for the remaining tumor.

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HER2-positive squamous cell breast cancer in complete remission

Patient Info: Anonymized, Female, 40s | Stage II

Biomarkers: HER2-positive squamous cell breast cancer, ER/PR negative, PD-L1 negative

Clinical complete remission and survival beyond 4 years after mastectomy, AC-TH chemotherapy, and HER2-directed maintenance therapy for Stage IIA HER2-positive primary squamous cell breast cancer.

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Stage I lung adenocarcinoma: post-lobectomy hemothorax resolved with tPA/DNase

Patient Info: Anonymized, Female, 70+ | Stage I

Early-stage lung adenocarcinoma was surgically treated with left upper lobectomy; postoperative hemothorax resolved after chest-tube drainage, bronchoscopy, and intrapleural tPA/DNase, with no hemothorax recurrence at follow-up.

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Rare squamous cell breast cancer: tumorectomy and partial mastectomy

Patient Info: Anonymized, Female, 40s | Stage I

Biomarkers: ER-negative; PR-negative; HER2-negative; Ki-67 21%, triple negative

As of August 2024, she had no recurrence 4 years after surgery, adjuvant AC/docetaxel chemotherapy, and residual breast irradiation for Stage I squamous cell carcinoma of the breast arising in a benign phyllodes tumor.

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How I Discovered My LUNG CANCER

Patient Info: Donnita, Female, 60s

As of November 2024, Donnita was sharing her experience as a lung cancer survivor after Stage IA2 non-small cell lung adenocarcinoma found through screening and treated surgically.

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Stage III lung adenocarcinoma: neoadjuvant brigatinib, surgery, no evidence of disease

Patient Info: Anonymized, Female, 50s | Stage III

Biomarkers: Specific molecular alteration not stated in case 1 raw text; treated with brigatinib

No evidence of disease on PET-CT and brain MRI 27 months after surgery while receiving adjuvant brigatinib 90 mg daily.

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Stage III EML4-ALK lung adenocarcinoma: brigatinib, surgery, no evidence of disease

Patient Info: Anonymized, Female, 40s | Stage III

Biomarkers: EML4-ALK fusion rearrangement

No evidence of disease on PET-CT, with no brain metastases on MRI, after 32 months of adjuvant brigatinib following response and surgery.

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Stage III EGFR-mutated lung adenocarcinoma: osimertinib and surgery

Patient Info: Anonymized, Female, 70+ | Stage III

Biomarkers: EGFR L858R; EGFR L861Q

No evidence of disease on PET-CT or brain MRI after 42 months of follow-up following neoadjuvant osimertinib and surgery.

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Stage III EGFR exon 19-deleted lung adenocarcinoma: osimertinib and surgery

Patient Info: Anonymized, Female, 50s | Stage III

Biomarkers: EGFR exon 19 deletion

No sign of metastasis on PET-CT or brain MRI after 24 months of follow-up following neoadjuvant osimertinib, left upper-lobe resection, and adjuvant osimertinib.

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Secretory breast carcinoma: mastectomy, surveillance, no recurrence at 2 years

Patient Info: Anonymized, Female, 40s

Biomarkers: ER-negative; PR-negative; HER2-negative

No local recurrence or metastasis after 2 years of follow-up after right mastectomy and axillary lymph-node dissection for triple-negative secretory breast carcinoma.

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EGFR Lung Cancer: Jill's Survivor Story

Patient Info: Jill Feldman, Female, Under 40

Biomarkers: EGFR-positive

As of November 2024, Jill described living 15 years after her 2009 lung cancer diagnosis; current disease status and whether she remained on treatment were not clearly stated.

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Stage III Colorectal Cancer: Jazz's Patient Story

Patient Info: Jazz Page, Male | Stage III

As of November 2024, Jazz was still in active treatment planning with radiation, oral chemotherapy pills, and final surgery expected; no post-treatment remission status was reported.

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Stage IIIA HR-positive HER2-negative breast cancer with radiation-induced brachial plexopathy

Patient Info: Anonymized, Female, 50s | Stage I

Biomarkers: HR-positive/HER2-negative breast cancer with pathogenic ATM and PALB2 variants plus an ATM VUS.

Approximately 3.5 years after radiation therapy, there was no evidence of breast cancer recurrence, but severe radiation-induced brachial plexopathy, fibrosis, telangiectasias, and lymphedema-related symptoms required ongoing supportive care.

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Stage IV HER2-Positive Breast Cancer: Nina's Survivor Story

Patient Info: Nina, Female, Under 40 | Stage IV

Biomarkers: HER2-positive; broad hereditary genetic testing negative

Metastatic Site: spine

As of November 2024, Nina described being in a no-evidence-of-disease phase, while continuing treatment because of her Stage IV HER2-positive metastatic breast cancer history.

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Triple-Negative Breast Cancer in a Young Woman With Bloom Syndrome Followed by Myelodysplastic Syndrome

Patient Info: Anonymized, Female, Under 40

Biomarkers: Triple-negative

Follow-up imaging after breast-cancer treatment showed no malignant lesions. Eight months after treatment, she developed myelodysplastic syndrome with excess blasts and later died from sepsis at age 33.

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Stage III MET Exon 14-Positive Lung Adenocarcinoma Treated With Targeted Therapy Before Surgery

Patient Info: Anonymized, male, 60s | Stage I

Biomarkers: MET exon 14 skipping mutation; TP53 mutation

Postoperative pathology showed no involved lymph nodes and a lower pathologic Stage I group after treatment. No relapse was seen at the 6-month postoperative follow-up.

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Stage II Invasive Ductal Carcinoma: Lauren's Survivor Story

Patient Info: Lauren, Female | Stage II

As of November 2024, Lauren had completed surgery, chemotherapy, and 25 rounds of radiation for Stage II invasive ductal breast cancer and was moving into survivorship.

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Breast invasive lobular carcinoma metastatic to the endometrium: hysterectomy and hormone therapy

Patient Info: Anonymized, Female, 50s | Stage IV

Biomarkers: HER2 negative, PR/HER2 negative.

Metastatic Site: endometrium (endometrial polyp)

No signs of recurrence were reported 18 months after total hysterectomy with bilateral adnexectomy for endometrial metastasis from invasive lobular breast carcinoma, with scheduled follow-up every 3 to 6 months.

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Stage 1 lung cancer found after chest injury

Patient Info: Anonymized, Female, 70+

No lung cancer recurrence and no cardiovascular events were reported 12 months after right lower lobectomy and lymph node dissection for Stage IA2 papillary lung adenocarcinoma.

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Hormone receptor-positive breast cancer metastatic to the pituitary: surgery and disease-free follow-up

Patient Info: Anonymized, Female, 40s | Stage IV

Biomarkers: ER 2+; PR 1+; HER2 0; GATA3 positive; CA125 elevated

Metastatic Site: pituitary

Disease-free 11 months after surgical resection of pituitary metastasis from prior hormone receptor-positive, HER2-negative breast cancer, with postoperative recovery supported by antibiotics, hormone replacement/supportive therapy, and electrolyte management.

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