Stage IV Colorectal Cancer: Kasey's Patient Story

Patient Info: Kasey, Female, Under 40 | Stage IV

Biomarkers: CEA elevated; no genomic biomarker reported

Metastatic Site: liver

Kasey was diagnosed with Stage II colon cancer in February 2024 and progressed to Stage IV disease with a liver lesion in September 2024. As of April 2025, she was continuing chemotherapy after liver surgery.

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Stage III colon cancer followed by a second gastro-oesophageal adenocarcinoma

Patient Info: Anonymized, Female | Stage III

Biomarkers: KRAS-mutated, NRAS-negative, BRAF-negative

After surgery and 4 cycles of CAPEOX, imaging initially showed no metastases. Later imaging showed new bilobar liver lesions, and a separate primary gastro-oesophageal adenocarcinoma was diagnosed about 1 year after the colon cancer.

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Stage III Colorectal Adenocarcinoma: Chloe's Survivor Story

Patient Info: Chloe, Female | Stage III

Biomarkers: Familial adenomatous polyposis

As of April 2025, Chloe was in remission after emergency surgery with a stoma and 4 rounds of IV/oral chemotherapy for Stage III FAP-associated colon adenocarcinoma.

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Early-stage mixed breast carcinoma found during LGI1 limbic encephalitis workup

Patient Info: Anonymized, Female | Stage I

Biomarkers: ER 95-100% positive; PR 80% positive; HER2-negative

She gradually recovered after immunotherapy for limbic encephalitis and excision of the early-stage breast tumor, and had returned to part-time work 12 months after discharge.

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Lung inflammation from pembrolizumab immunotherapy returned months after stopping treatment

Patient Info: Anonymized, Female, 70+

Biomarkers: Estrogen receptor-negative; progesterone receptor-negative; HER2-negative

Surgery confirmed a pathologic complete response, and she remained in breast-cancer remission during routine follow-up after treatment for recurrent pembrolizumab-related pneumonitis.

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Breast cancer linked to a rare kidney condition believed to be cancer-related

Patient Info: Anonymized, Female, 50s

Biomarkers: ER-positive; PR-positive; HER2 score 1+; Ki-67 5-10%

At the latest follow-up, she had no local or distant breast-cancer recurrence and maintained excellent performance status.

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Metastatic Neuroendocrine Breast Cancer With Severe Hormone Overproduction

Patient Info: Anonymized, Female, Under 40 | Stage IV

Biomarkers: ER-negative, PR focally positive, HER2-negative, PIK3CA mutation

Metastatic Site: liver, bone

Died after rapid deterioration and cardiac arrest during progressive metastatic disease.

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HER2-positive breast cancer with brain metastases: responding well to T-DXd

Patient Info: Anonymized, Female, 50s | Stage IV

Biomarkers: ER-positive; PR-positive; HER2-positive / HER2 IHC 3+

Metastatic Site: brain (left cerebellum, left frontal lobe, medulla)

After 14 months and 19 doses of T-DXd, brain metastases remained controlled with no symptomatic or radiological relapse and no severe T-DXd-related adverse events.

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Stage 4 SMARCA4-deficient lung cancer: ongoing treatment response

Patient Info: Anonymized, Male, 50s | Stage IV

Biomarkers: SMARCA4-deficient lung cancer with BRG-1 loss, CK/CK7 positive, Ki-67 >40%. CEA

Metastatic Site: sigmoid colon, left adrenal gland

After colon metastasis surgery, continued radiotherapy, and later gemcitabine/nedaplatin/bevacizumab/camrelizumab for adrenal metastasis, the cancer showed a favorable response with no further recurrence or new metastasis reported.

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HER2-Positive Breast Cancer Treated After Chemotherapy-Related Hemorrhagic Cystitis

Patient Info: Anonymized, Female, 40s

Biomarkers: ER-negative, PR-negative, HER2-positive

Under surveillance with no evidence of breast-cancer recurrence for 2 years.

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HER2-Positive Invasive Ductal Breast Cancer Treated After Chemotherapy-Related Hemorrhagic Cystitis

Patient Info: Anonymized, Female, 50s

Biomarkers: ER-positive, PR-positive, HER2-positive

Under surveillance for 2 years with no signs of malignancy.

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Ductal Carcinoma In Situ With Persistent Vaccine-Related Lymph Node Swelling

Patient Info: Anonymized, Female, 50s

Biomarkers: ER-positive, PR-positive

Recovered uneventfully after mastectomy, with no additional cancer treatment given.

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Clinical Stage IB lung adenocarcinoma: no recurrence after thoracoscopic lobectomy and pneumatocele repair

Patient Info: Anonymized, Male, 60s | Stage I

Biomarkers: No molecular biomarkers reported; tumor markers were normal: CEA 2.1 ng/mL, SCC antigen 1.5 ng/mL, cytokeratin 19 fragment 0.9 ng/mL

As of March 2025, the patient had no recurrence after thoracoscopic left lower lobectomy for lung adenocarcinoma; postoperative pneumatocele-related air leak resolved with reinforcement and adhesive therapy.

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Bilateral inflammatory breast cancer treated with pembrolizumab and surgery

Patient Info: Anonymized, Female, 40s | Stage III

Biomarkers: Bilateral breast cancers had different biology: right side ER/PR-positive and HER2 FISH-negative; left side triple-negative/HER2 1+.

As of March 2025, she had no recurrence 6 months after bilateral mastectomy, bilateral axillary lymph node dissection, thoracoabdominal flap closure, and planned postmastectomy radiation for Stage IIIC bilateral inflammatory breast cancer.

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Right Stage IIB ER/PR-positive breast cancer with left epithelioid MPNST: no recurrence after surgery

Patient Info: Anonymized, Female, 70+ | Stage II

Biomarkers: Right breast cancer was ER/PR-positive, HER2-negative/1+

As of March 2025, 3 years after bilateral mastectomy, there was no recurrence of the right breast cancer or the left epithelioid malignant peripheral nerve sheath tumor; she remained on anastrozole for the right breast cancer.

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Left breast epithelioid MPNST with concurrent right breast cancer: no recurrence after surgery

Patient Info: Anonymized, Female, 70+ | Stage III

Biomarkers: Left MPNST markers included S100 and SOX10 positivity. Right breast cancer was ER/PR-positive, HER2-negative/1+

As of March 2025, 3 years after bilateral mastectomy, there was no recurrence of the left epithelioid MPNST or the concurrent right breast invasive ductal carcinoma.

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Cardiac arrest during rectal cancer surgery caused by an anal-cardiac reflex

Patient Info: Anonymized, Male, 50s

The operation was completed after successful resuscitation from two intraoperative cardiac arrests, and he had no related cardiac-arrest sequelae during the following year.

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Breast Cancer: Tia's Patient Story

Patient Info: Tia

After breast cancer surgery, Tia was active and focused on restoring shoulder mobility and managing early lymphedema symptoms.

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Localized lung adenocarcinoma: disease-free after CT-guided marking and VATS wedge resection

Patient Info: Anonymized, Female, 50s

Biomarkers: No lung molecular biomarkers reported; prior malignant melanoma had BRAF codon 600 mutation

As of March 2025, she remained free of signs of lung cancer recurrence after CT-guided marking, VATS wedge resection, and mediastinal lymph node sampling.

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Stage III Colorectal Cancer: Chloe's Survivor Story

Patient Info: Chloe, Female, Under 40 | Stage III

Biomarkers: Rare genetic disorder/gene reported; exact gene not stated

Chloe was diagnosed with Stage III colon cancer in February 2024 after emergency surgery. After surgery, stoma creation, and 3 months of chemotherapy, she was told she was in remission in June 2024 and remained on surveillance.

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Stage II Colorectal Cancer: Kristin's Survivor Story

Patient Info: Kristin, Female | Stage II

Kristin had Stage II colon cancer treated with emergency surgery and 4 months of chemotherapy. Her February 2022 scan confirmed no evidence of disease, and as of March 2025 she had recently celebrated 3 years cancer-free.

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Mark: Stage III Colorectal Cancer

Patient Info: Mark, Male, Under 40 | Stage III

Biomarkers: Lynch syndrome negative

As of March 2025, Mark was sharing his story after surgery and intensive chemotherapy for Stage IIIB colon cancer and had been declared to have no evidence of disease in 2021.

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Breast Cancer: Erica's Survivor Story

Patient Info: Erica Deligne, Female

As of March 2025, Erica Deligne was a breast cancer survivor and style advocate helping people understand aesthetic flat closure and post-surgery confidence.

Invasive Lobular Carcinoma: Claudia's Survivor Story

Patient Info: Claudia, Female, 40s

Biomarkers: Grade 3

As of March 2025, Claudia described herself as a breast cancer survivor and advocate after mastectomy for multifocal grade 3 ILC, with whole-person healing and community support central to recovery.

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