Stage 4 luminal A breast cancer: tumor regression on hormone therapy

Patient Info: Anonymized, Female, 40s | Stage IV

Biomarkers: ER-positive; PR-positive; HER2-negative

Metastatic Site: skin, soft tissue, lungs

Metastatic Luminal A breast cancer involving skin/soft tissue and lungs showed regressing tumors and stable lung metastasis after 3 months of anti-hormone therapy plus capecitabine; longer-term control was not reported.

PubMed CentralRead more →

Stage IV EGFR Non-Small Cell Lung Cancer: Leah's Patient Story

Patient Info: Leah Phillips, Female, 40s | Stage IV

Biomarkers: EGFR exon 19 deletion

Metastatic Site: bone (spine, pelvis); malignant right pleural…

As of July 2024, Leah remained on daily Tagrisso with stable Stage IV EGFR-mutated lung cancer, no reported progression, healing/sclerotic bone metastases, and durable response for more than 4 years.

The Patient StoryRead more →

Stage IV EGFR-mutated lung cancer with acquired resistance to osimertinib

Patient Info: Anonymized, Female, 70+ | Stage IV

Biomarkers: EGFR L858R; acquired EGFR T790M; acquired EGFR L718Q

Metastatic Site: pleura, bone

After temporary disease control with sequential EGFR-targeted therapies, the right lung lesion enlarged again in June 2021; she was alive at the latest follow-up.

PubMed CentralRead more →

First primary lung cancer treated with SBRT in a patient with multiple cancers

Patient Info: Anonymized, male, 70+

At 43 months after the first SBRT, there was no local recurrence and the patient remained alive and walking independently.

PubMed CentralRead more →

Second primary lung cancer treated with SBRT two years later

Patient Info: Anonymized, male, 70+

At 17 months after the second SBRT, the left-lung lesion had shrunk with no local recurrence, and the patient remained alive and walking independently.

PubMed CentralRead more →

Finding A Lump To BREAST CANCER!

Patient Info: Kelsey Harrison, Female, Under 40 | Stage II

Biomarkers: ER-positive

As of July 2024, Kelsey had completed chemotherapy, double mastectomy with axillary lymph-node removal, and radiation, and was continuing tamoxifen plus Lupron ovarian suppression with additional planned systemic therapy.

The Patient StoryRead more →

Stage IV Non-Small Cell Lung Cancer: Lenny's Survivor Story

Patient Info: Lenny, Male, 50s | Stage IV

Biomarkers: PD-L1 expression positive

Metastatic Site: right femur; brain/cerebellum

As of July 2024, Lenny described himself as NED/no evidence of disease after surgery, CyberKnife radiation, chemotherapy, and Keytruda-based immunotherapy.

The Patient StoryRead more →

RET-rearranged metastatic lung cancer responding to selpercatinib after pralsetinib

Patient Info: Anonymized, female, 50s | Stage IV

Biomarkers: KIF5B-RET fusion; PD-L1 negative

Metastatic Site: brain

More than 5 years after her 2018 diagnosis, selpercatinib was ongoing after 8 months with continued brain response and stable lung disease.

PubMed CentralRead more →

HER2-positive breast cancer: surgery after neoadjuvant therapy

Patient Info: Anonymized, Female, 60s | Stage I

Biomarkers: ER 1% weakly positive; PR-negative; HER2-positive

No evidence of disease on follow-up while taking anastrozole after pathologic complete response to neoadjuvant T-DM1, lumpectomy/SLNB, radiotherapy, and adjuvant trastuzumab for Stage I HER2-positive breast cancer.

PubMed CentralRead more →

HER2-positive Stage I breast cancer: residual microinvasion after neoadjuvant T-DM1

Patient Info: Anonymized, Female, 70+ | Stage I

Biomarkers: ER-negative; PR-negative; HER2-positive

No evidence of disease on follow-up after neoadjuvant T-DM1, lumpectomy/SLNB showing only residual microinvasion/DCIS, continued adjuvant T-DM1 to 17 total cycles, and 52.5 Gy radiotherapy.

PubMed CentralRead more →

Five-year survival with extensive-stage small cell lung cancer on atezolizumab

Patient Info: Anonymized, Male, 50s | Stage IV

Metastatic Site: bilateral lungs, cervical lymph nodes

Five years after diagnosis with extensive-stage small cell lung cancer, he was alive and well on maintenance atezolizumab with no further documented progression after the 2020–2021 rechallenge, reaching 60 months overall survival and about 44 months progression-free survival.

PubMed CentralRead more →

Stage II Invasive Lobular Carcinoma: Lizzie's Survivor Story

Patient Info: Lizzie, Female | Stage II

Lizzie completed mastectomy, reconstruction-related surgery and 5 weeks of radiation. She remained on a planned 10-year course of an aromatase inhibitor and became active in breast cancer research advocacy.

Lobular Breast Cancer AllianceRead more →

Stage IV triple-negative breast cancer in remission: CBD and exercise for neuropathy

Patient Info: Anonymized, Female, 50s | Stage IV

Biomarkers: Triple-negative breast cancer. Blood and immune inflammation measures were tracked during neuropathy care.

Metastatic Site: liver

She was in remission for more than 5 years after Stage IV breast cancer with a solitary liver metastasis, while later managing chemotherapy-induced peripheral neuropathy with CBD and an exercise program that improved symptoms and function.

PubMed CentralRead more →

Small cell lung cancer discovered after recurrent pneumothorax

Patient Info: Anonymized, male, 60s

Follow-up chest CT showed only postsurgical changes with no evidence of tumor, and he was doing well under oncology follow-up.

PubMed CentralRead more →

Radiation pneumonitis during chemoradiotherapy for Stage III squamous lung cancer

Patient Info: Anonymized, Male, 70+ | Stage III

An 88-year-old man with Stage III squamous lung cancer developed radiation pneumonitis during chemoradiotherapy, with symptoms and imaging improving after steroid treatment.

PubMed CentralRead more →

Stage 3 breast cancer: pathologic complete response to neoadjuvant chemotherapy

Patient Info: Anonymized, Female, Under 40

Biomarkers: ER-positive, PR-negative, HER2-negative breast cancer with very high Ki-67. MammaPrint high-risk/basal type; hereditary testing negative.

Free of recurrence at last follow-up after neoadjuvant pembrolizumab plus chemotherapy, breast-conserving surgery with RCB-0/pathologic complete response, adjuvant radiation, and adjuvant pembrolizumab.

PubMed CentralRead more →

MET-Positive Metastatic Lung Cancer That First Appeared as a Breast Mass

Patient Info: Anonymized, Female, 70+ | Stage IV

Biomarkers: MET exon 14 skipping mutation; acquired MET and resistance mutations

Metastatic Site: breast, liver, right adrenal gland

Capmatinib produced a marked response across most disease sites at 3 months, but a right adrenal metastasis progressed by 6 months while other sites continued responding.

PubMed CentralRead more →

EGFR-mutated lung cancer with later small-cell transformation

Patient Info: Anonymized, male, 60s | Stage IV

Biomarkers: EGFR L858R mutation; acquired EGFR T790M mutation

Metastatic Site: pleura/chest wall, ribs, brain, meninges,…

Disease progressed through multiple lines of therapy with brain and meningeal involvement. He died in September 2021, more than 9 years after his original 2012 diagnosis.

PubMed CentralRead more →

Stage IV Colorectal Cancer: Jessica's Survivor Story

Patient Info: Jessica Dazzler, Female, Under 40 | Stage IV

Biomarkers: FoundationOne testing performed; exact mutation not stated

Metastatic Site: lungs, spine, rib

As of May 2024, Jessica said it took 3 years and 4 months to reach no evidence of disease after Stage IV colorectal cancer, though she remained anxious about future scans and possible circulating cancer.

The Patient StoryRead more →

Stage IVA lung adenocarcinoma with solitary brain metastasis: pCR after brain surgery, chemoradiation, immunotherapy, and lobectomy

Patient Info: Anonymized, Male, 70+ | Stage IV

Biomarkers: PD-L1 75%; negative for driver gene mutations and translocations

Metastatic Site: brain

As of May 2024, he had no recurrence after brain metastasis resection and radiation, carboplatin/pemetrexed/atezolizumab, robot-assisted right upper lobectomy with pathologic complete response, and 13 cycles of maintenance atezolizumab.

PubMed CentralRead more →

Stage III Colorectal Cancer: Andrea's Survivor Story

Patient Info: Andrea, Female, Under 40 | Stage III

As of May 2024, Andrea had completed radiation with continuous 5-FU, 8 intensive chemotherapy infusions, tumor surgery with temporary ileostomy, and ileostomy reversal; a liver-lesion scare was a false alarm and she was cancer-free.

The Patient StoryRead more →

Stage 4 breast cancer: hip reconstruction preserves mobility

Patient Info: Anonymized, Female, 50s | Stage IV

Metastatic Site: bone (right acetabulum/pelvis: ilium, ischium,…

As of May 2024, 2 years after reconstruction for metastatic breast cancer involving the right acetabulum/pelvis, she had no recurrence of hip pain and had returned to baseline function; overall systemic cancer response was not reported.

PubMed CentralRead more →

Secretory breast cancer: mastectomy and radiotherapy to no evidence of disease

Patient Info: Anonymized, Female, 60s | Stage II

Biomarkers: ER-negative; PR-negative; HER2-negative; Ki-67 50%; tumor-infiltrating lymphocytes 60%

As of May 2024, 6 months after mastectomy and adjuvant radiotherapy for pT2N0M0 triple-negative secretory breast cancer, clinical examination and imaging showed no evidence of relapse.

PubMed CentralRead more →

Stage III Inflammatory Breast Cancer: Katrece's Patient Story

Patient Info: Katrece Nolen, Female | Stage III

More than 10 years after her diagnosis, Katrece was taking medication intended to reduce recurrence risk and remained active in advocacy for people with inflammatory breast cancer.