Stage IV Breast Cancer: Queen's Patient Story

Patient Info: Queen, Female, Under 40 | Stage IV

As of June 2025, Queen was living with Stage IV/metastatic breast cancer after multiple surgeries, setbacks, spread, and another tumor, while focusing on faith, self-advocacy, and living each day fully.

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Stage IV HER2-Positive Breast Cancer: Kathleen's Patient Story

Patient Info: Kathleen McEvoy-Schufreider, female, 60s | Stage IV

Biomarkers: HER2-positive

Metastatic Site: liver, bones

Kathleen continued long-term treatment for metastatic breast cancer, including infusions every 3 weeks after resuming the PATINA regimen outside the trial.

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ALK-rearranged lung adenocarcinoma: sustained partial response on reduced-dose crizotinib after renal cysts

Patient Info: Anonymized, Male, 50s | Stage III

Biomarkers: ALK gene translocation positive in >15% of tumor cells by FISH

As of June 2025, the lung cancer remained in partial response without progression on reduced-dose crizotinib, while crizotinib-associated renal cysts had markedly regressed.

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Stage IV Lung Adenocarcinoma With KRAS Mutation Responding to Immunotherapy and Anti-Angiogenic Treatment

Patient Info: Anonymized, male | Stage IV

Biomarkers: KRAS mutation; MET amplification

Metastatic Site: pleura

By the December 2023 follow-up, the pleural effusion had disappeared, the primary lung tumor had not progressed, and he was described as symptom-free and in good health on maintenance treatment.

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Metastatic rectal cancer: complete response after repeat SBRT to oligoprogressive right lung lesion

Patient Info: Anonymized, Female, 70+ | Stage IV

Metastatic Site: liver; lung

As of June 2025, imaging 20 months after repeat SBRT showed a complete response of the treated right lower lobe lung lesion with no tumor progression.

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Metastatic male breast cancer: complete metabolic response after restarting anastrozole, leuprolide, abemaciclib, zoledronic acid, and radiation

Patient Info: Anonymized, Male, 60s | Stage IV

Biomarkers: ER >95%; PR >95%; HER2/neu-negative; Ki-67 30%; PIK3CA exon 21 pathogenic variant; BRCA1 not mutated; BRCA2 not mutated

Metastatic Site: bone (vertebral bodies T2-T6, L1, and L5)

As of May 2025, after restarting endocrine and targeted therapy and receiving palliative radiation, the last two PET scans showed complete metabolic response without disease progression, and brain MRI showed no metastasis.

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Stage III Colorectal Cancer: James's Survivor Story

Patient Info: James, Male | Stage III

James had Stage IIIC / possible Stage IV rectal cancer with major lymph node involvement and an uncertain liver spot. After chemotherapy, radiation, multiple surgeries, permanent colostomy, and adjuvant chemotherapy, he later reported no evidence of disease.

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Stage III HR-Positive Invasive Lobular Carcinoma: Tanya's Patient Story

Patient Info: Tanya, Female, 40s | Stage III

Biomarkers: ER-positive; PR-positive; HER2-negative; grade 1

As of May 2025, Tanya was recovering from chest wall surgery, ALT flap repair, and a later skin graft after developing angiosarcoma in her radiated reconstructed breast years after Stage IIIA ILC treatment.

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Stage II BRCA2 Invasive Ductal Carcinoma: Onjalai's Survivor Story

Patient Info: Onjalai Brown, Female, Under 40 | Stage II

Biomarkers: Patient-specific biomarker/genetic result not reported; family history suggests BRCA2 mutation

After lumpectomy, 20 rounds of chemotherapy and 36 rounds of radiation for Stage II invasive ductal carcinoma with lymph-node involvement, Onjalai had been cancer-free for 3 years as of May 2025.

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Small-cell lung cancer: complete response complicated by radiation bronchial injury and adrenal recurrence

Patient Info: Anonymized, Male, 40s | Stage IV

Metastatic Site: left adrenal gland

As of May 2025, the initial lung and mediastinal disease had achieved complete response, but the patient developed severe radiation-related bronchial injury and later left adrenal metastasis requiring renewed systemic chemotherapy.

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Stage IV ALK Non-Small Cell Lung Cancer: Alisa's Patient Story

Patient Info: Alisa Secaida, Female, Under 40 | Stage IV

Biomarkers: ALK-positive / ALK-rearranged

Metastatic Site: Brain; lymph nodes

As of May 2025, after alectinib and lung surgery, pathology still showed active tumor and lymph-node cancer cells, and Alisa was receiving IMRT for remaining disease.

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Stage IA invasive lobular breast cancer with ipsilateral marginal zone lymphoma: no recurrence after surgery and radiation

Patient Info: Anonymized, Female, 70+ | Stage I

Biomarkers: Breast cancer was ER-positive, PR-negative, HER2-negative. Separate marginal zone lymphoma showed CD20/Bcl-2 markers

As of May 2025, five-month follow-up imaging showed no recurrence of the right breast invasive lobular carcinoma and no clinical recurrence of the ipsilateral marginal zone lymphoma.

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Stage IV EGFR Lung Cancer: Natasha's Patient Story

Patient Info: Natasha, Female | Stage IV

Biomarkers: EGFR-positive

Metastatic Site: brain

Natasha had Stage IV EGFR-positive lung cancer with brain metastases. Tagrisso/osimertinib was her main treatment, but a new brain metastasis later appeared and was treated with Gamma Knife. As of May 2025, she was awaiting follow-up MRI while continuing care.

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Triple-negative sebaceous carcinoma of the breast: no recurrence after multimodality treatment

Patient Info: Anonymized, Female, Under 40

Biomarkers: Triple-negative sebaceous breast carcinoma; EMA-positive; Ki-67 50-60%; inherited breast/ovarian cancer testing negative for pathogenic variants.

As of May 2025, after surgery, adjuvant chemotherapy, and radiation, she had 5 years of follow-up with no evidence of neoplastic recurrence.

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Small-cell lung cancer with anti-GABAb paraneoplastic limbic encephalitis: complete response after radiochemotherapy

Patient Info: Anonymized, Female, 70+

Biomarkers: CSF anti-GABAb antibodies positive

As of May 2025, follow-up imaging after combined radiochemotherapy showed complete resolution of the right hilar lung mass and right medial temporal hypermetabolism, and the patient had no further seizures.

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Breast cancer first discovered after it had already spread to the spinal cord

Patient Info: Anonymized, Female, 40s | Stage IV

Biomarkers: Estrogen receptor-positive; progesterone receptor-negative; HER2 score 0

Metastatic Site: intramedullary spinal cord (D11-D12); bilateral…

Her paraplegia did not improve after spinal radiation, and she died from disease progression 3 months after the breast-cancer diagnosis.

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Stage II HR-Positive Breast Cancer: Kelsey's Patient Story

Patient Info: Kelsey, Female, Under 40 | Stage II

Biomarkers: ER-positive

As of May 2025, Kelsey had completed chemotherapy, double mastectomy with reconstruction, and 16 radiation sessions, and was continuing tamoxifen with Verzenio planned for 2 years plus Lupron ovarian-suppression shots.

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Stage II HR-Positive Invasive Ductal Carcinoma: LaShae's Patient Story

Patient Info: LaShae, Female, Under 40 | Stage II

Biomarkers: ER-positive; comprehensive genetic panel negative

As of May 2025, LaShae had completed mastectomy for Stage IIB ER-positive breast cancer with 2 positive lymph nodes and was undergoing chemotherapy, with radiation and 5-10 years of hormone therapy planned.

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Recurrent breast cancer with pleural disease: capecitabine stopped after cardiac complications

Patient Info: Anonymized, Female, 50s | Stage IV

Metastatic Site: pleura

As of May 2025, she was living with recurrent breast cancer involving the pleura after stopping capecitabine because of major cardiac complications; cardiac symptoms were medically managed with stable NYHA class II dyspnea at 3-month follow-up.

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Stage IV HR-Positive Invasive Ductal Carcinoma: Samantha's Patient Story

Patient Info: Samantha, Female, Under 40 | Stage IV

Biomarkers: ER-positive; PR-positive; HER2-positive

Metastatic Site: Rib; spine; pelvis

After a mixed response on the radium trial, Samantha changed to anastrozole and abemaciclib. She described the newer hormone-targeted combination as easier to tolerate and working better while remaining in ongoing treatment.

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Stage III HR-Positive Breast Cancer: Christine's Survivor Story

Patient Info: Christine, Female, Under 40 | Stage III

Biomarkers: ER-positive; PR-positive; HER2-positive

Three years after diagnosis, Christine described herself in the survivorship stage and focused on the physical and emotional effects that continued after active treatment.

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Breast Cancer: Lourdes's Survivor Story

Patient Info: Lourdes del Río, Female

Biomarkers: Oncotype test performed; score/result not reported

As of May 2025, Lourdes described herself as cancer-free and 100% healthy, with a mammogram and ultrasound from the previous day coming out perfect.

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How We Got Here: 6 Young Lung Cancer Patients & Their Paths To Surgery- Part 1

Patient Info: Leah Phillips, Female | Stage IV

Biomarkers: EGFR exon 19 deletion

Metastatic Site: bone (pelvis; spine; ribs)

As of April 2025, Leah was living with Stage IV EGFR exon 19 deletion lung cancer while continuing Tagrisso after SBRT and right middle lobe lobectomy.

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Stage IV Colorectal Cancer: Albita's Patient Story

Patient Info: Albita, Female, Under 40 | Stage IV

Biomarkers: Described as wild type; no hereditary genetic marker reported

Metastatic Site: liver

Albita had Stage IV colon cancer with liver metastases. As of April 2025, the only active cancer she described was still in the liver, with 3 spots remaining after chemotherapy, radiation, liver resection, hysterectomy/colon surgery, ileostomy, and ongoing/planned liver-directed treatment.

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