Breast Cancer Recurrence in the Small Intestine and Bone More Than 5 Years After Diagnosis

Patient Info: Anonymized, Female, 50s | Stage IV

Biomarkers: Initial ER-positive, PR-positive, HER2-negative; metastatic lesion ER-negative, PR-negative, triple negative

Metastatic Site: small intestine, bone, right fallopian tube

More than 5 years after her December 2018 diagnosis, she was alive at 1-year follow-up after metastatic recurrence, with multiple bone metastases still present.

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Stage IV Lung Adenocarcinoma With Delayed Pembrolizumab-Related Pneumonitis

Patient Info: Anonymized, female, 70+ | Stage IV

Metastatic Site: contralateral lung

After brachytherapy and continued pembrolizumab, imaging 1 year later showed a smaller right hilar lesion with otherwise stable disease. She later recovered from delayed pembrolizumab-related pneumonitis after immunotherapy had been stopped.

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Stage I Breast Cancer and a Separate Mixed Primary Liver Cancer in a 62-Year-Old Woman

Patient Info: Anonymized, Female, 60s | Stage I

Biomarkers: HER2/CerbB-2 positive

Postoperative pathology showed Stage I breast cancer, and the breast tumor did not progress.

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Stage III Lung Cancer: Heidi's Survivor Story

Patient Info: Heidi, Female | Stage III

As of November 2024, Heidi was 6 years beyond her Stage IIIA lung cancer diagnosis and active in survivorship and advocacy through The White Ribbon Project; no explicit NED status was provided.

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ROS1-Positive Stage III Pulmonary Sarcomatoid Carcinoma With Complete Pathologic Response

Patient Info: Anonymized, male, 60s | Stage III

Biomarkers: ROS1 rearrangement; TP53 mutation; PD-L1 TPS 0%

No recurrence was seen for more than 30 months after surgery following a complete pathologic response.

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Stage III Pulmonary Sarcomatoid Carcinoma With Major Response to Neoadjuvant Treatment

Patient Info: Anonymized, male, 50s | Stage III

Biomarkers: PIK3CA mutation; TP53 mutation; PD-L1 TPS 5%

No recurrence was detected for more than 29 months after surgery.

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Stage III Pulmonary Sarcomatoid Carcinoma With Major Response and No Recurrence

Patient Info: Anonymized, male, 50s | Stage III

Biomarkers: NRAS mutation; TP53 mutation; PD-L1 TPS 60%

No recurrence was detected for more than 27 months after surgery.

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Stage III Pulmonary Sarcomatoid Carcinoma Treated With Neoadjuvant Immunochemotherapy and Surgery

Patient Info: Anonymized, male, 60s | Stage III

Biomarkers: TP53 mutation; PD-L1 TPS 40%

No recurrence was detected for more than 30 months after surgery.

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Stage IV EGFR Non-Small Cell Lung Cancer: Filipe's Patient Story

Patient Info: Filipe, Male, Under 40 | Stage IV

Biomarkers: EGFR exon 19 deletion

Metastatic Site: brain, bone, left lung, kidney

As of November 2024, Filipe was living with ongoing Stage IV EGFR exon 19-mutated lung cancer after initial response to osimertinib, later progression and current amivantamab plus chemotherapy.

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Stage IV Colorectal Cancer: Monica's Patient Story

Patient Info: Monica, Female, Under 40 | Stage IV

Metastatic Site: lymph nodes

As of November 2024, Monica was still in active treatment, but lymph nodes had shrunk after chemotherapy and further surgery plus additional chemotherapy were planned.

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Stage IV Breast Cancer: Nina's Survivor Story

Patient Info: Nina, Female, Under 40 | Stage IV

Metastatic Site: Spine

As of November 2024, Nina had Stage IV metastatic breast cancer with prior spine metastasis, remained on indefinite infusions and medications, and had current scans showing no evidence of disease.

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Jazz: Stage III / borderline Stage IV colorectal cancer

Patient Info: Jazz, Male | Stage III

As of November 2024, Jazz was in active treatment for Stage III / borderline Stage IV colorectal cancer after colostomy surgery, chemotherapy, stomach tumor removal, and radiation, with surgery still planned for the remaining tumor.

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HER2-positive squamous cell breast cancer in complete remission

Patient Info: Anonymized, Female, 40s | Stage II

Biomarkers: HER2-positive squamous cell breast cancer, ER/PR negative, PD-L1 negative

Clinical complete remission and survival beyond 4 years after mastectomy, AC-TH chemotherapy, and HER2-directed maintenance therapy for Stage IIA HER2-positive primary squamous cell breast cancer.

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Stage IV Colorectal Adenocarcinoma: Casandra's Patient Story

Patient Info: Casandra, Female, Under 40 | Stage IV

Metastatic Site: Liver, lungs

As of November 2024, Casandra had been diagnosed just over a month earlier and was receiving aggressive every-2-week systemic therapy with the goal of shrinking disease enough to create surgical options.

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Lung Adenocarcinoma With Immune-Related Abdominal Inflammation and Later Bone Progression

Patient Info: Anonymized, male | Stage IV

Biomarkers: PD-L1 30%; KRAS G13X mutation; EGFR/ALK/ROS1 negative

Metastatic Site: bone

After several periods of response or stability, lymph-node progression recurred and bone progression was documented in July 2024. Another treatment line was being planned.

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Rare squamous cell breast cancer: tumorectomy and partial mastectomy

Patient Info: Anonymized, Female, 40s | Stage I

Biomarkers: ER-negative; PR-negative; HER2-negative; Ki-67 21%, triple negative

As of August 2024, she had no recurrence 4 years after surgery, adjuvant AC/docetaxel chemotherapy, and residual breast irradiation for Stage I squamous cell carcinoma of the breast arising in a benign phyllodes tumor.

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Stage III Colorectal Cancer: Jazz's Patient Story

Patient Info: Jazz Page, Male | Stage III

As of November 2024, Jazz was still in active treatment planning with radiation, oral chemotherapy pills, and final surgery expected; no post-treatment remission status was reported.

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Stage IIIA HR-positive HER2-negative breast cancer with radiation-induced brachial plexopathy

Patient Info: Anonymized, Female, 50s | Stage I

Biomarkers: HR-positive/HER2-negative breast cancer with pathogenic ATM and PALB2 variants plus an ATM VUS.

Approximately 3.5 years after radiation therapy, there was no evidence of breast cancer recurrence, but severe radiation-induced brachial plexopathy, fibrosis, telangiectasias, and lymphedema-related symptoms required ongoing supportive care.

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Stage IV HER2-Positive Breast Cancer: Nina's Survivor Story

Patient Info: Nina, Female, Under 40 | Stage IV

Biomarkers: HER2-positive; broad hereditary genetic testing negative

Metastatic Site: spine

As of November 2024, Nina described being in a no-evidence-of-disease phase, while continuing treatment because of her Stage IV HER2-positive metastatic breast cancer history.

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Stage IV HER2-Positive Non-Small Cell Lung Cancer: Samantha's Patient Story

Patient Info: Samantha, Female | Stage IV

Biomarkers: HER2 mutation

Metastatic Site: Lungs/pleural fluid; liver

As of November 2024, Samantha reported a 55% reduction across the board on chemotherapy plus immunotherapy, few side effects, improved energy, and enough function to hike, work, and feel more like herself.

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Stage 4 small-cell lung cancer: ongoing response to immunotherapy

Patient Info: Anonymized, Male, 50s | Stage IV

Biomarkers: PD-L1-negative

Metastatic Site: liver, bone, brain

Extensive-stage small-cell lung cancer had complete response in the primary lung, liver, bone, and treated brain lesions, with partial response in hilar/mediastinal nodes; after about 20 months of serplulimab-based first-line therapy, the patient had no deterioration, no immunotherapy-related adverse effects, and high quality of life.

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Stage II Invasive Ductal Carcinoma: Lauren's Survivor Story

Patient Info: Lauren, Female | Stage II

As of November 2024, Lauren had completed surgery, chemotherapy, and 25 rounds of radiation for Stage II invasive ductal breast cancer and was moving into survivorship.

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Triple-Negative Breast Cancer in a Young Woman With Bloom Syndrome Followed by Myelodysplastic Syndrome

Patient Info: Anonymized, Female, Under 40

Biomarkers: Triple-negative

Follow-up imaging after breast-cancer treatment showed no malignant lesions. Eight months after treatment, she developed myelodysplastic syndrome with excess blasts and later died from sepsis at age 33.

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Breast invasive lobular carcinoma metastatic to the endometrium: hysterectomy and hormone therapy

Patient Info: Anonymized, Female, 50s | Stage IV

Biomarkers: HER2 negative, PR/HER2 negative.

Metastatic Site: endometrium (endometrial polyp)

No signs of recurrence were reported 18 months after total hysterectomy with bilateral adnexectomy for endometrial metastasis from invasive lobular breast carcinoma, with scheduled follow-up every 3 to 6 months.

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