Etoposide Desensitization After Cardiac Arrest in Metastatic Small Cell Lung Cancer

Patient Info: Anonymized, female, 60s | Stage IV

Metastatic Site: brain

After later tumor progression and further systemic treatment, she died in September 2021 from multifactorial progressive leukoencephalopathy, meningopyoventriculitis, and brain atrophy.

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Breast cancer history: atypical pelvic fracture after long-term zoledronic acid

Patient Info: Anonymized, Female, 60s | Stage Metastatic/Advanced

Prior breast cancer treatment had been completed; CT during fracture evaluation showed no metastatic disease, and the atypical iliac wing fracture healed progressively with conservative care and teriparatide.

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Stage II Triple-Negative Breast Cancer With Severe Myelitis During Pembrolizumab Treatment

Patient Info: Anonymized, Female, 60s | Stage II

Biomarkers: ER-negative, PR-negative, HER2-negative, germline PALB2 variation

Imaging showed a complete tumor response before surgery, and surgery 6 months later found no residual breast cancer or involved sentinel nodes.

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EGFR-Mutant Lung Adenocarcinoma That Transformed to Small Cell Lung Cancer

Patient Info: Anonymized, female, 40s | Stage IV

Biomarkers: EGFR exon 19 deletion

Metastatic Site: brain, adrenal gland, liver, thyroid

The cancer progressed after small-cell transformation with adrenal, thyroid, liver and brain involvement, and she died 52.7 months after the original diagnosis from disease progression and organ failure.

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Metastatic Lung Cancer With Pulmonary Embolism, Cardiac Tamponade, and Recurrent Stroke

Patient Info: Anonymized, female, 70+ | Stage IV

Metastatic Site: leptomeninges

After the lung cancer was diagnosed, she developed leptomeningeal metastases and recurrent ischemic strokes and died the following month.

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EGFR-Mutant Lung Adenocarcinoma That Transformed to Small Cell Lung Cancer

Patient Info: Anonymized, female, 40s | Stage IV

Biomarkers: EGFR exon 19 deletion; acquired EGFR T790M mutation

Metastatic Site: liver

The cancer progressed after transformation to small cell lung cancer, and she died 49 months after the original diagnosis.

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HER2 exon 20 metastatic lung adenocarcinoma with pathologic complete response after chemoimmunotherapy and surgery

Patient Info: Anonymized, Female, 40s | Stage IV

Biomarkers: HER2 exon 20 insertion lung adenocarcinoma with TP53 mutation, PD-L1 TPS 50%, and low TMB.

Metastatic Site: contralateral lung

Right lower lobectomy with radical lymphadenectomy in November 2023 showed pathologic complete response, and no additional therapy was offered after surgery.

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Stage 4 lung cancer: managing pembrolizumab-induced myasthenia gravis

Patient Info: Anonymized, Female, 70+ | Stage IV

Biomarkers: Anti-acetylcholine receptor antibody elevated; TSH elevated during immune-related adverse event workup; cancer biomarkers not reported

At 9 months after the immune-related myasthenia gravis presentation, lung cancer remained in complete response while she continued low-dose prednisolone, pyridostigmine, levothyroxine, and nighttime NIV.

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Stage III HR-Positive Invasive Lobular Carcinoma: Katie's Patient Story

Patient Info: Katie, Female, Under 40 | Stage III

Biomarkers: ER-positive; PR-positive; HER2-negative; genetic testing negative

As of February 2025, Katie was a few months beyond active treatment for Stage III ER-positive, PR-positive, HER2-negative ILC and was adjusting to maintenance therapy with Verzenio, Lupron, and Letrozole.

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Stage 4 lung adenocarcinoma with RET fusion responding to pralsetinib

Patient Info: Anonymized, Male, 60s | Stage IV

Biomarkers: RET fusion

Metastatic Site: pleura

As of March 2025, he had recovered from grade 3 Pneumocystis jirovecii pneumonia, restarted pralsetinib, and had no progressive disease or recurrence of adverse events over 13 months.

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Triple-Negative Breast Cancer and Urgent Fertility Preservation Before Chemotherapy

Patient Info: Anonymized, Female, 40s

Biomarkers: ER-negative, PR-negative, HER2-negative, triple negative

Chemotherapy had started, and the breast-cancer treatment course was still ongoing.

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Recurrent lung adenocarcinoma: sick sinus syndrome during anlotinib treatment

Patient Info: Anonymized, Female, 70+

Biomarkers: driver genes negative

Recurrent/progressive lung adenocarcinoma was being treated with anlotinib when sick sinus syndrome developed; the patient received a permanent pacemaker and remained alive under follow-up, but post-pacemaker cancer status was not fully reported.

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Radiation-induced breast sarcoma after breast cancer radiotherapy: 4-patient case series

Patient Info: Anonymized, Female

Biomarkers: TP53 mutation reported in 1 patient; all 4 radiation-induced breast sarcomas were undifferentiated pleomorphic sarcoma

Across the 4-patient case series, follow-up was variable: 1 patient remained disease-free, 1 recurred within 1 year, 1 had no recurrence for 7 years before unrelated death, and the patient with metastases progressed over 9 months.

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Stage III Colorectal Cancer: Katie's Survivor Story

Patient Info: Katie, Female | Stage III

As of February 2025, Katie had no evidence of disease after surgery and 6 cycles of chemotherapy and was continuing reassuring follow-up, including ctDNA testing.

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Stage III Colorectal Adenocarcinoma: Katie's Survivor Story

Patient Info: Katie, Female | Stage III

Katie completed surgery and chemotherapy for Stage IIIB transverse colon adenocarcinoma. Her ctDNA tests have been negative since surgery, scans have been clean, and treatment ended in summer 2023; as of February 2025, she was in survivorship and follow-up.

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Colorectal Cancer: Cattie's Patient Story

Patient Info: Cattie Fleming, Female

Cattie remained on chemotherapy, and her most recent scans showed that treatment was effective.

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Stage IV Triple-Negative Breast Cancer: Maggie's Survivor Story

Patient Info: Maggie, Female | Stage IV

Biomarkers: ER-negative; PR-negative; HER2-negative

Metastatic Site: lungs, lymph nodes; possible liver

Diagnosed in 2022 with de novo Stage IV triple-negative breast cancer involving the lungs and lymph nodes, with possible liver involvement. After entering a chemotherapy/immunotherapy clinical trial, she reported being cancer-free / no evidence of disease for well over 1 year as of February 2025.

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Stage III Colorectal Cancer: Edie's Survivor Story

Patient Info: Edie, Female, 50s | Stage III

After total neoadjuvant treatment, lower anterior resection, and ileostomy reversal, Edie reported clear scans/colonoscopies and described herself as a colon cancer survivor. As of February 2025, she remained in survivorship.

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Facing Triple-Negative Breast Cancer: Chance’s Story

Patient Info: Chance, Female, Under 40 | Stage II

Biomarkers: ER-negative; PR-negative; HER2-negative; BRCA1 mutation

As of February 2025, Chance described follow-up after Stage II BRCA1-associated triple-negative breast cancer and stated that she did not currently have cancer, while continuing close surveillance.

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Stage III Triple-Negative Breast Cancer: Kelly's Survivor Story

Patient Info: Kelly, Female, Under 40 | Stage III

Biomarkers: Triple-negative breast cancer; no inherited cancer gene mutation found.

As of February 2025, Kelly identified as a Stage IIIC triple-negative breast cancer survivor after neoadjuvant chemotherapy, double mastectomy with reconstruction, and radiation, and was using her experience to support others through TNBC Thrivers.

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Stage III Colorectal Cancer: Denelle's Survivor Story

Patient Info: Denelle, Female | Stage III

As of February 2025, Denelle had a complete response to total neoadjuvant therapy for Stage IIIB rectal cancer, avoided surgery, and was in active surveillance with scans and scopes every 3 months.

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Stage 4 small cell lung cancer with paraneoplastic neurological syndrome

Patient Info: Anonymized, Female, 60s | Stage IV

Biomarkers: Paraneoplastic antibody panel positive for anti-Hu, anti-AMPH, anti-Ri

Metastatic Site: left axillary lymph nodes

Over 2 years of follow-up, CT showed stable complete response, tumor markers stayed normal, no new metastases appeared, and neurological symptoms did not worsen.

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Genetic testing confirms a local recurrence of Stage III sigmoid colon cancer

Patient Info: Anonymized, Male, 50s | Stage III

Biomarkers: KRAS, PIK3CA, BRAF -negative

One year after surgery for the local recurrence, he remained free of both local recurrence and distant metastases.

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Small Cell Lung Cancer: Brian's Patient Story

Patient Info: Brian, Male, 40s

As of February 2025, Brian was actively receiving chemotherapy and twice-daily radiation for limited-stage small cell lung cancer and remained hopeful during treatment.

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