Gastric adenocarcinoma with a rare choriocarcinoma component and rapid liver and lung spread

This gastric cancer diagnosis at a glance

Stage at diagnosis
Stage IV
Subtype
Adenocarcinoma
Biomarkers
hCG-positive, HER2-positive
Sex
male
Spread to
liver, lung
Treatment
surgery
Outcome
In Memory

Treatment course, step by step

  1. Radical subtotal gastrectomy with D2 lymph-node dissection was performed after correction of severe anemia. 5-fluorouracil chemotherapy was recommended after metastatic disease appeared but was not started.
  2. Transarterial embolization was used to control bleeding from a ruptured liver metastasis.
  3. He later declined further treatment.

What happened, in summary

A 65-year-old man developed several months of upper-abdominal discomfort and black stools before seeking care. Endoscopic biopsy showed gastric adenocarcinoma, and he arrived severely anemic from bleeding. After transfusions corrected the anemia, he underwent radical subtotal gastrectomy with D2 lymph-node dissection.

Pathology showed a rare mixed tumor: poorly differentiated gastric adenocarcinoma together with a choriocarcinoma component. The tumor extended through the stomach wall, and 1 of 38 regional lymph nodes contained cancer. The choriocarcinoma component produced large amounts of hCG, and tumor staining was also positive for HER2.

Soon after surgery, imaging showed a new lung nodule and multiple suspicious liver lesions. Within days, repeat CT demonstrated multiple lung and liver metastases and enlarged abdominal lymph nodes, establishing Stage IV disease. One liver metastasis ruptured and bled internally. Angiography confirmed the bleeding site, and transarterial embolization was performed to control the hemorrhage.

5-fluorouracil chemotherapy had been recommended, but he did not proceed with it and later declined further treatment. After discharge, his condition worsened rapidly. He died 18 days later from hemorrhagic shock related to the bleeding metastatic liver disease.

Where this story comes from

This is a lay summary of an account first published by PMC / PubMed Central. Read the original in full

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