Recurrent Ovarian Cancer and Olaparib-Related Skin Toxicity

Patient Info: Anonymized, Female | Stage Metastatic/Advanced

Metastatic Site: peritoneum|liver

The latest chemotherapy was effective, and she was alive without signs of another recurrence at the last documented follow-up.

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Stage IV ovarian cancer complicated by a spontaneous vaginal fistula

Patient Info: Anonymized, Female, 50s | Stage IV

After postoperative chemotherapy, she was clinically well and imaging showed no visible tumor during 8 months of follow-up.

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Ovarian Granulosa Cell Tumor Recurring 17 Years After Surgery

Patient Info: Anonymized, Female, 70+

Biomarkers: Weak oestrogen sensitivity

Complete resection was not possible, but debulking relieved pressure on surrounding structures and improved her quality of life. She then continued oncology care with palliative carboplatin and paclitaxel.

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Metastatic Clear Cell Ovarian Cancer Complicated by Treatment-Related Sarcoidosis

Patient Info: Anonymized, Female, 60s | Stage Metastatic/Advanced

Metastatic Site: peritoneum

During a treatment holiday, biopsy and laboratory evaluation showed treatment-related sarcoidosis rather than ovarian-cancer spread in the enlarged lymph nodes. After prednisone, the sarcoidosis resolved and imaging showed no progression of the clear cell ovarian cancer; she remained clinically well 4 months later.

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Stage 4 Ovarian Cancer Discovered During Trigeminal Neuralgia Evaluation

Patient Info: Anonymized, Female, 50s | Stage IV

Three months after surgery, she had recovered well from debulking and 6 total chemotherapy cycles, with complete macroscopic clearance achieved at surgery. Trigeminal-neuralgia symptoms persisted and continued to require daily medication.

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Kidney Complications After Treatment for Stage IV Ovarian Cancer

Patient Info: Anonymized, Female, 60s | Stage IV

Metastatic Site: peritoneum|left lymph node

No further ovarian-cancer progression was observed during the 10 months after kidney biopsy. The nephrotic syndrome reached partial remission after immunosuppressive treatment was stopped and supportive care continued.

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Ovarian Fibrosarcoma Recurring Rapidly After Debulking Surgery

Patient Info: Anonymized, Female, 40s

Biomarkers: Ki-67 greater than 20%; vimentin diffusely positive; muscle-specific antigen weakly positive

The cancer recurred with a new pelvic mass and ascites 3 months after surgery. Her condition was too poor for chemotherapy, and she died on the second day of palliative hospital care.

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Ovarian Cancer Relapse Causing Fluid Around the Heart

Patient Info: Anonymized, Female, 50s | Stage Metastatic/Advanced

Biomarkers: PAX8 positive; CK7 positive; WT1 positive; p53 positive; ER positive; PR negative; isolated PMS2 loss; MSH2 retained; MSH6 retained; MLH1 retained; two BRCA1 variants of uncertain significance

Metastatic Site: omentum|pericardium

She was alive after completing chemotherapy for the pericardial relapse and was receiving olaparib maintenance. The fluid around the heart did not recur immediately after the surgical window.

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Stage IV Ovarian Cancer With Severe Recurrent Ascites

Patient Info: Anonymized, Female | Stage IV

Metastatic Site: peritoneum|liver

The cancer progressed with massive ascites, liver involvement, and respiratory failure. She died from multiorgan failure related to metastatic ovarian cancer.

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Advanced Ovarian Cancer Presenting With Dermatomyositis

Patient Info: Anonymized, Female, 50s

Biomarkers: CA-125 3169 at diagnosis; later CA-125 rise with progression

After a partial response to second-line chemotherapy, nodal disease progressed again 5 months later and liposomal doxorubicin was planned.

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Ovarian Cancer With Pleural Spread and Recurrent Dermatomyositis

Patient Info: Anonymized, Female, 40s | Stage Metastatic/Advanced

Metastatic Site: pleura

She had symptomatic improvement after 2 cycles of carboplatin and liposomal doxorubicin for recurrent disease.

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Recurrent Ovarian Cancer With Dermatomyositis and Peritoneal Progression

Patient Info: Anonymized, Female, 50s

Her disease progressed during weekly paclitaxel, and she was considered unfit for further treatment.

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Stage IV ovarian cancer presenting as a persistent umbilical ulcer

Patient Info: Anonymized, Female, 40s | Stage IV

Metastatic Site: bilateral cardiophrenic lymph nodes

She recovered from extensive cytoreductive surgery without major abdominal or pulmonary complications and began adjuvant paclitaxel and carboplatin on postoperative day 25.

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Stage IV Ovarian Cancer With 20 Years of Tumor-Free Survival

Patient Info: Anonymized, female, 50s | Stage IV

Biomarkers: BRCA1 negative, BRCA2 negative

Metastatic Site: peritoneum, liver, right adrenal gland

Regular follow-up found no recurrence or other tumor, and at 20 years of follow-up she remained tumor-free with good health and quality of life.

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Stage II BRCA1 Ovarian Cancer: Barb's Patient Story

Patient Info: Barb White, female, 50s | Stage II

Biomarkers: BRCA1 mutation

Barb completed chemotherapy in June 2014 and later described being able to move forward after treatment.

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Stage III Ovarian Cancer: Dianne's Patient Story

Patient Info: Dianne Simpson, female, 70+ | Stage III

Dianne completed treatment in April 2017 after chemotherapy, hysterectomy and a pembrolizumab clinical trial and was looking ahead to survivorship.

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Stage II Ovarian Cancer: Betsy's Patient Story

Patient Info: Betsy Feldmann, 50s | Stage II

After treatment ended, Betsy returned to endurance events, including triathlon competition, long-distance cycling, and open-water swimming.

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Stage III Ovarian Cancer: Pam's Survivor Story

Patient Info: Pam Scarpino, female | Stage III

Pam had no evidence of disease in March 2010 after treatment for recurrence and remained in remission at the time of the story.

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Ovarian Adenosquamous Cancer Treated With Surgery and Chemotherapy

Patient Info: Anonymized, female, 50s | Stage I

Five and a half years after chemotherapy, she remained free of recurrence.

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Ovarian Cancer With Severe Dermatomyositis During Treatment

Patient Info: Anonymized, female, 60s | Stage III

Biomarkers: BRCA1 mutation

She continued paclitaxel and carboplatin while being treated for severe dermatomyositis and later described herself as finally on the mend.

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Stage I Ovarian Squamous Cell Cancer Found in a Long-Standing Dermoid Cyst

Patient Info: Anonymized, female, 40s | Stage I

At 22 months after treatment, she had no clinically identifiable recurrence.

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Metastatic Ovarian Cancer Discovered After Recurrent Embolic Strokes

Patient Info: Anonymized, female, Under 40 | Stage IV

Metastatic Site: left axillary lymph node

She received 1 cycle of paclitaxel and carboplatin and died on day 54 of her second hospital admission. Her family declined an autopsy.

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High-Grade Serous Ovarian Cancer With a Paraneoplastic Skin Condition

Patient Info: Anonymized, female, 60s

During first-line carboplatin and paclitaxel chemotherapy, the paraneoplastic skin changes regressed and the CA125 level returned to the normal range.

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High-Grade Serous Ovarian Cancer With Markedly Elevated Amylase

Patient Info: Anonymized, female | Stage III

At 6 months, she was receiving 3 additional chemotherapy cycles after an excellent initial clinical and imaging response, with later marker changes reflecting periods of progression and response.

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