Kidney Complications After Treatment for Stage IV Ovarian Cancer
This ovarian cancer diagnosis at a glance
- Stage at diagnosis
- Stage IV
- Subtype
- Adenocarcinoma
- Sex
- Female
- Spread to
- peritoneum|left lymph node
- Treatment
- surgery, chemotherapy and targeted therapy
- Outcome
- Stable Disease
Treatment course, step by step
- She underwent hysterectomy, removal of both ovaries and tubes, omental surgery, and lymph-node dissection.
- She then received 6 courses of carboplatin, paclitaxel, and bevacizumab.
- After recurrence, she received 8 courses of gemcitabine and carboplatin.
What happened, in summary
A 68-year-old woman underwent hysterectomy, removal of both ovaries and fallopian tubes, omental surgery, and lymph-node dissection for ovarian cancer in June 2016. Pathology showed high-grade serous adenocarcinoma classified as pT3N1M1, Stage IVB. Her urine testing had been normal before surgery.
She began carboplatin, paclitaxel, and bevacizumab in July 2016. Protein appeared in her urine and her blood pressure rose after 3 courses. Proteinuria persisted through 6 courses. In June 2017, the ovarian cancer returned with peritoneal dissemination and a left lymph-node metastasis, and she began gemcitabine with carboplatin.
After the eighth course, she developed leg swelling and was admitted in March 2018. Testing showed nephrotic syndrome, with urinary protein of 6.75 g/gCr and serum albumin of 2.7 g/dL. Kidney biopsy findings supported glomerular microangiopathy associated with bevacizumab, although gemcitabine-related injury could not be excluded. Prednisolone and mycophenolate did not produce a response and were tapered, after which supportive treatment continued.
About 10 months after the biopsy, the kidney condition reached partial remission. During the same period, no further progression of the ovarian cancer was observed.
Where this story comes from
This is a lay summary of an account first published by PMC / PubMed Central. Read the original in full
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Collections this story belongs to
- Stage 4 Ovarian Cancer 31 stories
- Bevacizumab for Ovarian Cancer 19 stories
These are lay summaries of published cancer stories, for information only. No two cancers behave the same way, and nothing here predicts your own diagnosis or replaces advice from your oncology team. Read the full disclaimer