Stage II HR-Positive Lung Cancer: Christine's Survivor Story

Patient Info: Christine, Female | Stage II

Biomarkers: Lung cancer biomarkers not reported; prior breast cancer described as ER-positive, PR-positive, HER2-positive / triple-positive

Reached complete remission from both Stage III triple-positive breast cancer and a separate Stage IIA primary lung cancer after about 1 year, including breast cancer chemotherapy/radiation and lower lung resection.

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Small Cell Lung Cancer: Mary's Survivor Story

Patient Info: Mary Casanova, Female

As of March 2023, Mary described herself as healthy and in remission after chemotherapy and radiation for small cell lung cancer; stage and metastatic sites were not stated.

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Stage IV ALK Non-Small Cell Lung Cancer: Dan's Patient Story

Patient Info: Dan, Male, Under 40 | Stage IV

Biomarkers: ALK-positive / ALK-rearranged

As of November 2022, Dan was living with Stage IV ALK-positive non-small cell lung cancer on Alectinib, with stable scans since spring 2020 and ongoing monitoring.

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Living with Stage 4 Lung Cancer (Plus Radiation & My Follow Up!) | Amy’s Story (3 of 3)

Patient Info: Amy, Female | Stage IV

Biomarkers: MET amplification

Metastatic Site: Bone/femur and hips; adrenal gland

As of July 2022, Amy was 3.5 years after Stage IV squamous cell lung cancer diagnosis, not NED but stable for about 3 years on Crizotinib with ongoing imaging and local treatment to lung/adrenal sites.

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Stage IV Non-Small Cell Lung Cancer: Abby's Survivor Story

Patient Info: Abby Kanarek, Female, 60s | Stage IV

Biomarkers: PD-L1 90%

Metastatic Site: Brain

As of November 2021, Abby was in remission 2 years after only 4 Keytruda infusions, with the lung cancer eliminated and ongoing surveillance by a multidisciplinary City of Hope team.

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Stage IV Lung Cancer: Anne's Patient Story

Patient Info: Anne LaPorte, Female | Stage IV

Biomarkers: Mutation identified by next-generation sequencing; specific mutation not reported

Metastatic Site: Spine; hips; lymph nodes; liver

As of November 2021, Anne was living with Stage IV lung cancer after oral treatment guided by tumor testing and later radiation, reporting a meaningful quality of life while advocating for self-advocacy and research.

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ECMO-Supported Airway Tumor Removal in Stage IIB Lung Cancer

Patient Info: Anonymized, Male, 50s | Stage II

He recovered from the emergency airway procedure and remained on systemic cancer treatment at the last follow-up.

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ECMO-Supported Airway Tumor Removal for Squamous Lung Cancer

Patient Info: Anonymized, Male, 60s

Bronchoscopy at three months found no malignancy, and he remained disease-free one year after hospital discharge.

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Stage I EGFR Lung Adenocarcinoma: Ashley's Patient Story

Patient Info: Ashley Stringer, Female, Under 40 | Stage I

Biomarkers: EGFR-positive

As of May 2021, Ashley was 4 years from diagnosis after lobectomy and 2 radiation courses, with ongoing monitoring of lung nodules and possible future EGFR-targeted therapy if needed.

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Immunotherapy and surgery for lung adenocarcinoma with two brain metastases

Patient Info: Anonymized, Female, 50s

Biomarkers: PD-L1 100%; no actionable mutations on next-generation sequencing.

After brain surgery, radiation, 11 cycles of pembrolizumab, and lung surgery, she was off treatment and under observation in remission.

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Chemotherapy, immunotherapy, and surgery for lung cancer that spread to the foot

Patient Info: Anonymized, Female, 70+

Biomarkers: PD-L1 20%; no actionable mutations on next-generation sequencing.

She had a significant response after four cycles of chemotherapy and pembrolizumab, and the resected lung nodule contained fibrosis and scar without carcinoma; further systemic treatment and radiation were under consideration.

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Pleomorphic Lung Cancer Progressed Despite Pembrolizumab

Patient Info: Anonymized, Male, 70+ | Stage IV

Biomarkers: EGFR-negative; ALK-negative; ROS1-negative; PD-L1 TPS 80%-90%.

Metastatic Site: small intestine; pleura; abdominal subcutaneous tissue

The cancer did not respond to pembrolizumab, and he died four months after immunotherapy began.

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Pembrolizumab Controlled Metastatic Pleomorphic Lung Cancer After Chemotherapy Failed

Patient Info: Anonymized, Male, 40s | Stage IV

Biomarkers: EGFR-negative; ALK-negative; ROS1-negative; BRAF-negative; PD-L1 TPS 60%-70%; BRCA2, and TP53 mutations; tumor mutation burden 42 mutations/Mb; no actionable alteration.

Metastatic Site: right adrenal gland; left adrenal gland; bone

Tumor diameter had decreased at 11 months, and pembrolizumab remained ongoing at 12 months.

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Lung Cancer Metastases to Both Kidneys Causing Kidney Failure

Patient Info: Anonymized, Male, 50s | Stage Metastatic/Advanced

Biomarkers: PD-L1 highly expressed

Metastatic Site: brain|bilateral kidneys|lungs

The cancer progressed in both kidneys and lungs despite treatment, causing dialysis-dependent kidney failure. He later developed severe respiratory illness and died 5 days after readmission.

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Delayed SMART syndrome after radiotherapy for small-cell lung cancer

Patient Info: Anonymized, Female, 60s

Her small-cell lung cancer remained in remission 12 years after treatment, although she developed SMART syndrome as a delayed complication of cranial irradiation.

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Cancer Survivor Story: Navigating Life with Lung Cancer (3/3)

Patient Info: Montessa Lee, Female, Under 40

As of March 2021, Montessa was a small cell lung cancer survivor and patient advocate after chemotherapy, radiation, and brain radiation; no cancer-free/NED claim or metastatic site was stated.

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Cancer Survivor Story: How I Got Through Chemo & Radiation (2/3)

Patient Info: Montessa Lee, Female, Under 40

As of March 2021, Montessa had gone through chemotherapy, radiation, and brain radiation for small cell lung cancer and was speaking as a survivor/advocate; no NED claim was stated.

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Cancer Survivor Story: How I Got Diagnosed with Lung Cancer (1/3)

Patient Info: Montessa Lee, Female, Under 40

As of March 2021, Montessa was sharing how she was diagnosed with small cell lung cancer at age 28 and later became a survivor/advocate after chemotherapy, radiation, and brain radiation.

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Stage III KRAS Non-Small Cell Lung Cancer: Terri's Survivor Story

Patient Info: Terri Conneran, Female | Stage III

Biomarkers: KRAS-mutated; PD-L1 level reviewed/tested

As of March 2021, Terri had Stage IIIA KRAS-mutated NSCLC with 3 local recurrences treated over time and had again reached no evidence of disease while continuing close surveillance and advocacy through KRAS Kickers.

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A painful scalp metastasis from sarcomatoid lung cancer

Patient Info: Anonymized, Female, 50s | Stage IV

Biomarkers: No targetable mutations identified; CAM5.2-positive; p63-positive; CD10-positive; vimentin-positive.

Metastatic Site: chest wall and rib; liver; right gluteal region; scalp…

Her disease progressed with a further liver lesion and additional metastatic complications, and systemic treatment was stopped because of severe immune-related toxicity and the absence of targetable mutations.

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Primary pulmonary adenoid cystic carcinoma found with chronic lymphocytic leukaemia

Patient Info: Anonymized, Male, 50s

Biomarkers: Cytokeratin-positive; SMA-positive; p63-positive; TTF-1-negative; S100-negative; CK20-negative; CD56-negative.

Six months after adjuvant radiation, restaging CT showed treatment-related changes without local or metastatic recurrence.

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Lung cancer remission after pembrolizumab despite severe inflammatory arthritis

Patient Info: Anonymized, Male, 50s | Stage Metastatic/Advanced

Biomarkers: PD-L1-positive.

Metastatic Site: brain (temporal and parietal lobes)

The lung adenocarcinoma remained in complete remission 28 months after diagnosis, while the treatment-related arthritis also reached sustained remission and he returned to work and exercise.

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Extensive-stage small cell lung cancer with acquired haemophilia

Patient Info: Anonymized, Female, 60s

Biomarkers: Synaptophysin weakly positive; Ki-67 greater than 90%.

Her small cell lung cancer remained stable on imaging one month before her death, which followed aseptic meningitis after intravenous immunoglobulin treatment for autoimmune myasthenia gravis.

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NRG1-Fusion Lung Cancer With a 24-Month Response to Afatinib

Patient Info: Anonymized, Female, 50s | Stage Metastatic/Advanced

Biomarkers: NRG1 fusion; KRAS/EGFR/ALK/ROS1/ERBB2 alterations not detected

Metastatic Site: left lung

Her cancer progressed during atezolizumab, and she died in May 2019.

PubMed CentralRead more →