Nivolumab-Related Myocarditis and Heart Block in Metastatic Lung Cancer

Patient Info: Anonymized, Male, 70+ | Stage IV

Metastatic Site: left adrenal gland

He stabilized after high-dose steroids and pacemaker implantation after nivolumab was permanently stopped.

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Osimertinib Improved Spinal Cord Metastases in Long-Standing Lung Cancer

Patient Info: Anonymized, Male, 50s | Stage IV

Biomarkers: Initial surgical specimen: no detected EGFR mutation and ALK-negative. Later pleural-fluid tumor: acquired EGFR T790M mutation with no other detected EGFR mutation.

Metastatic Site: cervical and mediastinal lymph nodes; bone; brain;…

Osimertinib improved neurologic function and kept the lung cancer stable for 14 months; he later died from bacterial pneumonia.

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Pembrolizumab Produced a Complete Response but Multiple Immune Side Effects

Patient Info: Anonymized, Female, 70+

Biomarkers: PD-L1 expression 100%. Seronegative for acetylcholine-receptor and listed paraneoplastic antibodies during myasthenia-gravis evaluation.

Imaging showed a complete oncologic response that persisted for at least six months after pembrolizumab stopped, while the immune complications resolved after intensive treatment.

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Speech and Swallowing Support After Lung Cancer Relapse

Patient Info: Anonymized, 70+ | Stage Metastatic/Advanced

Metastatic Site: both lungs

The lung cancer relapsed with mediastinal and supraclavicular lymph-node involvement and metastases in both lungs. Ongoing speech and swallowing support prevented reported dysphagia complications.

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Metastatic Lung Adenocarcinoma Complicated by Severe Nivolumab Pneumonitis

Patient Info: Anonymized, Male, 60s | Stage IV

Biomarkers: Microsatellite stable; low tumor mutation burden; PD-L1 70%

His severe nivolumab-related pneumonitis improved after infliximab.

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Stage IV Squamous Lung Cancer Resected After Response to Checkpoint Immunotherapy

Patient Info: Anonymized, male, 50s | Stage IV

After complete resection, he was alive, disease free and off treatment at postoperative follow-up.

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Stage III Lung Adenocarcinoma Resected After Chemotherapy and Checkpoint Immunotherapy

Patient Info: Anonymized, female, 60s | Stage III

After complete resection, she was alive, disease free and off treatment at postoperative follow-up.

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Metastatic Large Cell Neuroendocrine Lung Cancer With No Residual Tumor After Immunotherapy and Surgery

Patient Info: Anonymized, male, 50s

Surgical pathology showed fibrosis with no residual cancer, and he remained alive, disease free and off treatment at postoperative follow-up.

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Oligometastatic Lung Cancer With Brain Spread, Surgery and Later Recurrence

Patient Info: Anonymized, male, 60s | Stage IV

Metastatic Site: brain

After 15 months off treatment he developed mediastinal nodal and distant metastases and was alive with disease on platinum-based chemotherapy 25 months after surgery.

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A Lung Carcinoid Found During Evaluation of Severe Diarrhea

Patient Info: Anonymized, male, 50s

Biomarkers: neuron-specific enolase negative, chromogranin A negative

At 6-month follow-up, CT showed only previously noted emphysema, neuroendocrine tumor markers were negative, and he remained asymptomatic.

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Pulmonary Carcinoid Tumorlets Found After Lung Surgery for Chronic Cough and Bronchiectasis

Patient Info: Anonymized, male, 60s

His cough improved after lobectomy, an octreotide scan was normal, and he continued close follow-up with no evidence of distant metastasis or carcinoid syndrome.

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BRCA1 Non-Small Cell Lung Cancer: Nadine's Survivor Story

Patient Info: Nadine Beech, Female, Under 40

Biomarkers: Germline BRCA1 mutation for hereditary breast/ovarian cancer risk; lung cancer biomarker not reported

As of November 2016, Nadine was cancer-free after right bilobectomy for recurrent non-small cell lung cancer, following 19 years of lung cancer management that included left lower lobectomy, surveillance, Tarceva, and risk-reducing surgery for germline BRCA1.

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Pediatric Stage I intermediate-grade lung mucoepidermoid carcinoma: lobectomy with 1-year no recurrence

Patient Info: Anonymized, Male, Under 40 | Stage I

Biomarkers: Lymphovascular invasion negative; lymph node metastasis negative; PAS-positive mucin-rich cells

The child had no signs of tumor recurrence 1 year after lobectomy and received no adjuvant therapy because the tumor was localized and low/intermediate grade.

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Stage IB epithelial-myoepithelial lung carcinoma: no recurrence after VATS lobectomy

Patient Info: Anonymized, Female, 50s | Stage I

Biomarkers: Epithelial-myoepithelial lung carcinoma: EMA, actin and focal S-100 staining supported the diagnosis.

As of February 2014, she had no local recurrence or distant metastasis 16 months after video-assisted thoracoscopic left upper lobectomy and lymph node dissection for Stage IB epithelial-myoepithelial lung carcinoma.

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Stage IB squamous lung cancer: sleeve lobectomy complicated by pulmonary artery pseudoaneurysm

Patient Info: Anonymized, Male, 50s | Stage I

As of October 2013, he had normal quality of life and was cancer-free 1 year after the first operation, despite postoperative pulmonary artery pseudoaneurysm, completion pneumonectomy, and empyema treatment.

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Stage IIIA squamous lung cancer with later kidney and paraaortic lymph node metastases

Patient Info: Anonymized, Female, 50s | Stage IV

Biomarkers: Squamous lung cancer markers supported the diagnosis; TTF-1, CK7 and CK20 were not seen; Ki-67 >10%.

Metastatic Site: left renal parenchyma, paraaortic lymph nodes

After surgery, 4 cycles of cisplatin plus vinblastine, and mediastinal radiotherapy, she had a 10-month disease-free interval before biopsy-confirmed metastatic squamous lung carcinoma appeared in the left kidney with paraaortic lymph node enlargement.

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Stage IV EBV-positive lymphoepithelioma-like lung cancer with brain metastasis

Patient Info: Anonymized, Female, 50s | Stage IV

Biomarkers: EBV-positive by in-situ hybridization

Metastatic Site: brain, retroperitoneal/posterior mediastinal soft…

Remained well and disease-free 6 months after resection of the retroperitoneal/posterior mediastinal metastasis and 8 years after initial presentation.

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Stage IIIA pleomorphic lung cancer treated with surgery, chemotherapy, and radiation

Patient Info: Anonymized, Male, Under 40 | Stage III

Alive 14 months after surgery without evidence of tumor recurrence after complete resection, adjuvant chemotherapy, oral S-1, and radiation.

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Stage IV lung squamous cell carcinoma with liver metastasis treated with chemotherapy and 90Y radioembolization

Patient Info: Anonymized, Female, 50s | Stage IV

Metastatic Site: liver

After treatment for liver metastasis, PET CT 2 months after 90Y radioembolization showed complete tumor response without residual tumor, and she was alive without active disease.

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Stage IV large-cell lung cancer with adrenal metastasis: no recurrence after R0 surgery

Patient Info: Anonymized, Male, 60s | Stage IV

Biomarkers: Marker profile supported large-cell lung carcinoma: CK7/CEA/Ber-EP4 positive, with neuroendocrine and prostate markers negative.

Metastatic Site: left adrenal gland

Six months after combined lung and adrenal surgery with R0 resection, he had no evidence of recurrence.

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Stage IIIA squamous NSCLC: complete pathological response after docetaxel and lobectomy

Patient Info: Anonymized, Male, 60s | Stage III

Complete clinical response after 14 cycles of docetaxel was confirmed as a complete pathological response after right lobectomy.

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