Colon cancer patient with insulin autoimmune syndrome after FOLFOX, bevacizumab, and omeprazole

Patient Info: Anonymized, Male, 70+

Biomarkers: No cancer biomarkers reported. Insulin autoimmune syndrome followed chemotherapy/omeprazole exposure.

As of November 2025, the rare insulin autoimmune syndrome episode had improved after glucose supplementation and prednisone acetate, with blood glucose returning to the normal range during postoperative colon cancer treatment.

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Stage IV KRAS-mutant colorectal cancer with bilobar liver metastases: multimodality treatment and no evidence of disease

Patient Info: Anonymized, Female, 40s | Stage IV

Biomarkers: KRAS-mutated; BRAF wild-type; mismatch repair proficient

Metastatic Site: liver

After second liver resection, follow-up MRI at 8 weeks showed continued response at the SABR site and no recurrent disease; she was receiving adjuvant capecitabine and remained well.

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Stage I low rectal adenocarcinoma: ileal J-pouch salvage reconstruction after rectovaginal fistula

Patient Info: Anonymized, Female, 50s | Stage I

Biomarkers: CEA remained within normal range during follow-up; no molecular biomarkers reported

At 5 years after salvage reconstruction, colonoscopy showed no recurrence, stricture, or pouch complication; annual CT showed no local recurrence or distant metastasis; CEA remained normal and bowel function was satisfactory.

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Stage III dMMR transverse colon cancer: colectomy and adjuvant FOLFOX with no recurrence on CT

Patient Info: Anonymized, Male, 70+ | Stage III

Biomarkers: Loss of MLH1 and PMS2; BRAF mutation; MMR-deficient colorectal cancer

After colectomy and initiation of planned adjuvant FOLFOX, surveillance abdominal CT showed no recurrence or metastasis.

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Resected Stage IV colorectal cancer: no recurrence during xeligekimab treatment for psoriasis and hidradenitis suppurativa

Patient Info: Anonymized, Male, 40s | Stage IV

Biomarkers: No colorectal molecular biomarkers reported. CEA slightly high at follow-up; HBV DNA stayed suppressed on antiviral treatment.

Metastatic Site: liver

Six years after colorectal cancer surgery with liver-metastasis resection, surveillance showed no recurrence; during 28 weeks of xeligekimab follow-up, imaging and tumor markers showed no tumor progression.

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Stage IV Colorectal Cancer: Starr's Survivor Story

Patient Info: Starr, Female, 40s | Stage IV

Metastatic Site: Liver; peritoneum; lymph nodes

Starr had Stage IV colon cancer involving the liver, peritoneum, and lymph nodes. After chemotherapy, targeted therapy, and 2 surgeries in early 2025, she was told scans and circulating-tumor testing showed no visible cancer. As of October 2025, she described being in remission.

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The Cancer Spread One Year Later…

Patient Info: Kalei, Female, Under 40 | Stage IV

Metastatic Site: Lungs; bilateral lung nodules

Kalei initially had Stage II rectal cancer that responded to chemoradiation and IV chemotherapy without rectal surgery. In 2025, biopsy-proven lung metastasis changed the diagnosis to Stage IV. As of October 2025, she had undergone lung resections with clear margins and remained in ongoing follow-up rather than having a clearly stated NED status.

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Stage IV sigmoid colon cancer: recurrence after FOLFOX, hepatectomy, and colectomy

Patient Info: Anonymized, Male, 60s | Stage IV

Biomarkers: Mismatch repair proficient; microsatellite stable; KRAS wild-type; BRAF wild-type; CEA 3.8 ng/mL at diagnosis

Metastatic Site: liver, lung

As of September 2025, metastatic sigmoid colon cancer had recurred in the lungs and remnant liver after initial FOLFOX, hepatectomy, and colectomy, requiring FOLFIRI plus cetuximab.

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Stage IV BRAF Colorectal Cancer: Jackson's Patient Story

Patient Info: Jackson, Male, Under 40 | Stage IV

Biomarkers: BRAF mutation

Metastatic Site: Liver; peritoneal wall

Jackson had Stage IV BRAF-mutated colon cancer with extensive liver disease and later confirmed peritoneal-wall tumors. His treatment response was strong, with about 90% of liver disease estimated gone, but he remained on active treatment with possible future HIPEC evaluation. As of September 2025, he was responding well but not cancer-free.

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Stage IV Colorectal Cancer: Laura's Patient Story

Patient Info: Laura VanBrocklin, 40s | Stage IV

Metastatic Site: liver

After multiple procedures and surgery for Stage IV colorectal cancer with liver involvement, Laura was still finishing chemotherapy.

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Stage III Colorectal Cancer: Kara's Survivor Story

Patient Info: Kara Lionetta, Female | Stage III

An update to Kara's story reported that she was no evidence of disease while completing cleanup chemotherapy and planning later ileostomy reversal.

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Stage IV Colorectal Cancer: Claire's Patient Story

Patient Info: Claire, Female, 40s | Stage IV

Metastatic Site: Abdominal wall; lungs

As of September 2025, Claire was living with metastatic recurrent colorectal cancer as a chronic illness, receiving chemotherapy every 2 weeks since April 2018, approaching her 200th round, and maintaining stable disease with no signs of growth.

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Metastatic rectal cancer: total scapulectomy improves pain and function

Patient Info: Anonymized, Male, 40s | Stage IV

Biomarkers: CEA 418 ng/mL preoperatively; 10.3 ng/mL postoperatively; 7.2 ng/mL at 7 months; 11.1 ng/mL at about 5 months postoperatively; 6.4 ng/mL at 8 months

Metastatic Site: liver, right acromion/scapula, left adrenal gland

The patient had meaningful pain relief and functional recovery after total scapulectomy, but later developed liver and left adrenal progression and remained on palliative chemotherapy with a positive response.

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Colorectal Cancer: Shiva's Survivor Story

Patient Info: Shiva Sharma, Male, 40s

As of September 2025, Shiva described being told he was cancer-free after surgery and continued follow-up with scans every 6 months and regular colonoscopy.

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Stage III Colorectal Cancer: Nicole's Survivor Story

Patient Info: Nicole, Female, Under 40 | Stage III

Nicole completed surgery and 6 months of chemotherapy for Stage III sigmoid colon cancer. As of August 2025, she described good scans and bloodwork while managing survivorship issues, including lasting chemotherapy-related nerve damage.

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Colorectal Cancer: Samantha's Survivor Story

Patient Info: Samantha Fletcher, Female, Under 40

After surgery and 8 rounds of chemotherapy, Samantha completed treatment in March and scans showed no evidence of disease.

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Colorectal Cancer: Kathy's Survivor Story

Patient Info: Kathy Ball-Toncic, Female, 60s

As of August 2025, Kathy had been declared cancer-free again in August 2024 after treatment for breast DCIS and a later colorectal cancer, rebuilt strength with physical therapy, and completed a 162-mile Pan-Mass Challenge ride.

Dana-FarberRead more →

Stage IIIB sigmoid colon cancer: disease-free 1 year after sigmoidectomy

Patient Info: Anonymized, Female, 50s | Stage III

Biomarkers: CEA and CA19-9 were normal. Bone/node granulomas suggested sarcoid-like reaction rather than metastasis.

Disease-free 1 year after sigmoidectomy; sarcoid-like reaction lesions remained stable and postoperative CT did not show bone lesions.

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Stage IV Colorectal Cancer: Devon's Survivor Story

Patient Info: Devon, Female, Under 40 | Stage IV

Devon first reached no evidence of disease in February 2024, then had a Stage IV recurrence in August 2024. After additional chemotherapy and radiation ending January 2025, her June 2025 scans, bloodwork, and tumor markers were clear or negative.

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Stage IV Colorectal Cancer: Dan's Survivor Story

Patient Info: Dan Trombley, Male, Under 40 | Stage IV

Metastatic Site: Liver; portal vein; duodenum

As of July 2025, after Stage IV colon cancer that had spread through much of the liver and involved the portal vein and duodenum, Dan’s cancer had not returned and he had regained strength, returned to work, and welcomed a daughter in 2023.

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Stage III Colorectal Cancer: Ian's Survivor Story

Patient Info: Ian, Male, Under 40 | Stage III

Ian had Stage III sigmoid colon cancer treated with robotic laparoscopic surgery and adjuvant FOLFOX-based chemotherapy. As of July 2025, he described negative ctDNA tests and clear scans, with his oncologist comfortable saying he had been NED since surgery on December 13, 2022.

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Stage IIIB ascending colon cancer with later cervical and vaginal metastases, systemic nodal progression, and death

Patient Info: Anonymized, Female, 60s | Stage IV

Biomarkers: Primary colon cancer and vaginal/cervical metastasis both supported colorectal origin. MMR proteins were retained; HER2 0; Ki-67 high in metastasis.

Metastatic Site: cervix, vagina, rectal wall/serosa, systemic lymph…

After initial Stage IIIB ascending-colon cancer and later cervical/vaginal metastatic recurrence, CAPEOX was stopped because of cardiac toxicity; systemic lymph node metastases developed in early 2023, treatment was abandoned, and she died in April 2023.

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Stage IIIC ascending colon adenocarcinoma with appendiceal goblet-cell/signet-ring features: no recurrence at 46 months

Patient Info: Anonymized, Female, 60s | Stage III

Biomarkers: Colon tumor: MMR proteins retained, p53 positive, Ki-67 80%. Appendix lesion had neuroendocrine markers and Ki-67 10%.

At last follow-up on December 31, 2024, about 46 months after surgery, outside CT imaging and CEA testing showed no radiologic or biochemical evidence of tumor recurrence or metastasis.

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I Was SHOCKED At My STAGE 4 Diagnosis!

Patient Info: Lauren, Female, 40s | Stage IV

Metastatic Site: peritoneum / abdominal cavity

Lauren was early in treatment for Stage IV signet-ring cell colon cancer. As of July 2025, she was receiving chemotherapy, living with a colostomy, and hoping for enough response to allow further surgery or HIPEC; remission was not stated.

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