Stage III colon cancer: surgery and treatment story

Patient Info: Anonymized, Female | Stage III

As of June 2022, she had completed colon surgery and 6 months of IV chemotherapy for Stage III colon adenocarcinoma; recurrence, remission, or NED status was not stated.

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A young man with metastatic rectal cancer and inherited BRCA1 and MLH1 mutations

Patient Info: Anonymized, Male, Under 40 | Stage IV

Biomarkers: Germline BRCA1 c.4065_4068delTCAA and MLH1 c.232G>T mutations; tumor microsatellite instability-high; loss of MLH1 and PMS2 expression; elevated tumor mutational burden; loss of heterozygosity of wild-type MLH1.

Metastatic Site: liver

The rectal and liver tumors showed a partial response, no viable carcinoma was found in the resected liver lesions, and maintenance nivolumab continued without evidence of growth or recurrence.

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Stage IV Colorectal Cancer: Almudena's Survivor Story

Patient Info: Almudena, Female, Under 40 | Stage IV

Metastatic Site: Peritoneum

As of May 2022, Almudena was cancer-free after surgery and 12 chemotherapy sessions, had been medically cleared as cured after 6 years, and continued genetics follow-up because her case was unusual for her age.

Colorectal Cancer: Alejandro's Patient Story

Patient Info: Alejandro Mirazo, Male

Biomarkers: Lynch syndrome

Alejandro recovered quickly from colon surgery and had started a planned 4-cycle course of chemotherapy by May 2022, with ongoing surveillance for recurrence and other Lynch syndrome-associated cancers.

Stage IV KRAS Colorectal Cancer: Kris's Patient Story

Patient Info: Kris Sokolowski, Male, 40s | Stage IV

Biomarkers: KRAS mutation

Metastatic Site: Liver; sternum; spine; lymph nodes; omentum/abdominal…

As of May 2022, Kris was living with Stage IV KRAS G13D-mutant colorectal cancer. Most tumors had been stable or shrinking, but abdominal/omental disease continued to grow despite additional full-strength chemotherapy, so clinical-trial and immunotherapy options were being explored.

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Colon Cancer Returned in a Mesenteric Lymph Node 2 Years After Surgery

Patient Info: Anonymized, Male

The recurrent disease was removed with negative margins in a curative-intent operation. At 8 months, his weight was stable and his energy was improving.

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Stage IV Colorectal Cancer: Cindi's Survivor Story

Patient Info: Cindi, Female, 60s | Stage IV

Metastatic Site: Liver; abdominal lining/peritoneum

As of March 2022, Cindi had no recurrence more than 1 year after a clinical trial with nivolumab, investigational anti-tumor vaccine, chemotherapy, and surgery produced a complete pathologic response with no living cancer cells.

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Colorectal Cancer: Francisco's Survivor Story

Patient Info: Francisco Goyoaga, Male, 50s

As of February 2022, Francisco had overcome colorectal cancer after chemotherapy and ostomy-related treatment and no longer needed the ostomy bag.

Colorectal Cancer: Xue's Patient Story

Patient Info: Xue Ming, Male, Under 40

As of the January 2022 story, Xue Ming had undergone chemoradiation, chemotherapy, and successful sphincter-preserving rectal cancer surgery, with a temporary ileostomy and good 3-month recovery while follow-up care continued.

Stage III Colorectal Adenocarcinoma: Elizabeth's Survivor Story

Patient Info: Elizabeth, Female | Stage III

After treatment for a local recurrence, Elizabeth was declared cancer-free in February 2025 and continues to cope with fear of recurrence and life with a permanent ostomy.

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Stage II Colorectal Adenocarcinoma: Michael's Survivor Story

Patient Info: Michael | Stage II

Declared cancer-free in July 2024 after surgery, chemotherapy and radiation.

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Stage II Colorectal Adenocarcinoma: Gordon's Survivor Story

Patient Info: Gordon | Stage II

Gordon was declared cancer-free in September 2022 after surgery and chemotherapy.

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Stage IV Colorectal Cancer: Khoo's Patient Story

Patient Info: Khoo | Stage IV

Khoo remained on chemotherapy for Stage IV colorectal cancer and described becoming more optimistic over time.

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A R M

Patient Info: A R M | Stage III

They report that the colorectal cancer is in remission after surgery and chemotherapy.

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Colorectal Cancer: Li's Patient Story

Patient Info: Li Zong

Li Zong remained on chemotherapy and targeted therapy while considering future hospice and palliative care.

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Colon cancer at age 27 in a man later diagnosed with Lynch syndrome

Patient Info: Anonymized, Male, Under 40

Biomarkers: Germline pathogenic MSH2 variant NM_000251.2:c.942+3A>T identified later

The first colon cancer remained disease-free after partial colectomy and adjuvant chemotherapy; years later, he died after decline from metastatic pheochromocytoma.

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A second colon cancer leading to a Lynch syndrome diagnosis

Patient Info: Anonymized, Male, 40s

Biomarkers: Complete loss of MSH2 and MSH6 nuclear staining in the cecal tumor; germline pathogenic MSH2 variant NM_000251.2:c.942+3A>T; Lynch syndrome.

The cecal cancer was treated with complete colectomy, while later presumed recurrences were ultimately identified as meningiomas and metastatic pheochromocytoma; he died after the pheochromocytoma progressed.

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Colorectal Cancer: Barbara's Survivor Story

Patient Info: Barbara, Female, 40s

As of October 2021, Barbara described life after completed colon-cancer treatment, including survivorship, parenting, and a stronger perspective; recurrence was not described in this edited video.

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A Severe Delayed Immune Reaction After Treatment for Metastatic Colon Cancer

Patient Info: Anonymized, Male, 70+ | Stage IV

Metastatic Site: liver

He recovered from repeated episodes of severe cytokine release syndrome after prolonged corticosteroids, completed adjuvant FOLFOX and CV301 without nivolumab, and had no further CRS episodes.

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Stage III Colorectal Cancer: Brandon's Survivor Story

Patient Info: Brandon Dale, Male, 50s | Stage III

As of April 2021, Brandon was cancer-free 3 years after Stage III rectal cancer treatment, living normally with a permanent colostomy.

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Severe immune thrombocytopenia during treatment for metastatic colon cancer

Patient Info: Anonymized, Female, 50s | Stage IV

Biomarkers: KRAS-mutated; microsatellite stable; BRAF-wild type.

Metastatic Site: bilateral ovaries; pelvis; peritoneum; mesenteric…

After multiple metastatic recurrences and treatment changes, she died from progressive colon cancer; oxaliplatin had been permanently stopped after antibody-confirmed immune thrombocytopenia.

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Bilateral adrenal bleeding during bevacizumab treatment for metastatic colon cancer

Patient Info: Anonymized, Male, 50s | Stage IV

Biomarkers: RAS-mutant; BRAF-wild type; microsatellite stable.

Metastatic Site: peritoneum; liver; lung

Despite multiple systemic and local treatments, his metastatic colon cancer progressed in the liver and peritoneum, and he died from disease progression in November 2018.

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Stage IV Colorectal Cancer: Lee's Survivor Story

Patient Info: Lee Jones, Male, 50s | Stage IV

Metastatic Site: Liver

As of February 2021, Lee reported no evidence of colon cancer since 2011 after treatment for Stage IV colon cancer with liver metastases, recurrence, chemotherapy, colon surgery, and liver surgery.

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Rectal cancer liver surgery in a woman with mitochondrial disease

Patient Info: Anonymized, Female | Stage IV

Metastatic Site: liver; lungs; para-aortic lymph nodes

Three months after rectal and liver surgery, CT showed multiple lung metastases and para-aortic lymph-node metastasis, and FOLFIRI chemotherapy was resumed.

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