Ductal Carcinoma In Situ With Persistent Vaccine-Related Lymph Node Swelling

Patient Info: Anonymized, Female, 50s

Biomarkers: ER-positive, PR-positive

Recovered uneventfully after mastectomy, with no additional cancer treatment given.

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Bilateral inflammatory breast cancer treated with pembrolizumab and surgery

Patient Info: Anonymized, Female, 40s | Stage III

Biomarkers: Bilateral breast cancers had different biology: right side ER/PR-positive and HER2 FISH-negative; left side triple-negative/HER2 1+.

As of March 2025, she had no recurrence 6 months after bilateral mastectomy, bilateral axillary lymph node dissection, thoracoabdominal flap closure, and planned postmastectomy radiation for Stage IIIC bilateral inflammatory breast cancer.

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Right Stage IIB ER/PR-positive breast cancer with left epithelioid MPNST: no recurrence after surgery

Patient Info: Anonymized, Female, 70+ | Stage II

Biomarkers: Right breast cancer was ER/PR-positive, HER2-negative/1+

As of March 2025, 3 years after bilateral mastectomy, there was no recurrence of the right breast cancer or the left epithelioid malignant peripheral nerve sheath tumor; she remained on anastrozole for the right breast cancer.

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Left breast epithelioid MPNST with concurrent right breast cancer: no recurrence after surgery

Patient Info: Anonymized, Female, 70+ | Stage III

Biomarkers: Left MPNST markers included S100 and SOX10 positivity. Right breast cancer was ER/PR-positive, HER2-negative/1+

As of March 2025, 3 years after bilateral mastectomy, there was no recurrence of the left epithelioid MPNST or the concurrent right breast invasive ductal carcinoma.

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Breast Cancer: Tia's Patient Story

Patient Info: Tia

After breast cancer surgery, Tia was active and focused on restoring shoulder mobility and managing early lymphedema symptoms.

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Breast Cancer: Erica's Survivor Story

Patient Info: Erica Deligne, Female

As of March 2025, Erica Deligne was a breast cancer survivor and style advocate helping people understand aesthetic flat closure and post-surgery confidence.

Invasive Lobular Carcinoma: Claudia's Survivor Story

Patient Info: Claudia, Female, 40s

Biomarkers: Grade 3

As of March 2025, Claudia described herself as a breast cancer survivor and advocate after mastectomy for multifocal grade 3 ILC, with whole-person healing and community support central to recovery.

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Stage IV HER2-Positive Breast Cancer: Stephani's Survivor Story

Patient Info: Stephani St. Cyr, Female | Stage IV

Biomarkers: HER2-targeted treatments reported; no inherited cancer gene mutation found.

Metastatic Site: Bone; liver; brain

As of March 2025, Stephani had Stage IV metastatic breast cancer involving bone, liver, and brain, had no evidence of disease since July 2021, and continued HER2-targeted/systemic therapy.

Stage 1 breast cancer with benign esophageal tumor removed endoscopically

Patient Info: Anonymized, Female, 40s

Biomarkers: Leiomyoma IHC: desmin positive; αSMA positive; S100 negative; CD34 negative; c-kit negative; CD117 negative; GLUT1 negative

Right breast cancer had not recurred 5 years after resection, and the FDG-avid esophageal lesion was completely removed and confirmed to be benign leiomyoma.

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Breast cancer history: atypical pelvic fracture after long-term zoledronic acid

Patient Info: Anonymized, Female, 60s | Stage Metastatic/Advanced

Prior breast cancer treatment had been completed; CT during fracture evaluation showed no metastatic disease, and the atypical iliac wing fracture healed progressively with conservative care and teriparatide.

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Accessory breast cancer: surgery, radiation, endocrine therapy, no recurrence

Patient Info: Anonymized, Female, 50s | Stage I

Biomarkers: ER 2+/>95%; PR 3+/>95%; HER2-negative; Ki-67 2%

As of March 2025, 26 months after surgery, she continued anastrozole and breast MRI showed no evidence of recurrence.

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Stage II Triple-Negative Breast Cancer With Severe Myelitis During Pembrolizumab Treatment

Patient Info: Anonymized, Female, 60s | Stage II

Biomarkers: ER-negative, PR-negative, HER2-negative, germline PALB2 variation

Imaging showed a complete tumor response before surgery, and surgery 6 months later found no residual breast cancer or involved sentinel nodes.

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Stage III HR-Positive Invasive Lobular Carcinoma: Katie's Patient Story

Patient Info: Katie, Female, Under 40 | Stage III

Biomarkers: ER-positive; PR-positive; HER2-negative; genetic testing negative

As of February 2025, Katie was a few months beyond active treatment for Stage III ER-positive, PR-positive, HER2-negative ILC and was adjusting to maintenance therapy with Verzenio, Lupron, and Letrozole.

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Radiation-induced breast sarcoma after breast cancer radiotherapy: 4-patient case series

Patient Info: Anonymized, Female

Biomarkers: TP53 mutation reported in 1 patient; all 4 radiation-induced breast sarcomas were undifferentiated pleomorphic sarcoma

Across the 4-patient case series, follow-up was variable: 1 patient remained disease-free, 1 recurred within 1 year, 1 had no recurrence for 7 years before unrelated death, and the patient with metastases progressed over 9 months.

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Facing Triple-Negative Breast Cancer: Chance’s Story

Patient Info: Chance, Female, Under 40 | Stage II

Biomarkers: ER-negative; PR-negative; HER2-negative; BRCA1 mutation

As of February 2025, Chance described follow-up after Stage II BRCA1-associated triple-negative breast cancer and stated that she did not currently have cancer, while continuing close surveillance.

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Stage III Triple-Negative Breast Cancer: Kelly's Survivor Story

Patient Info: Kelly, Female, Under 40 | Stage III

Biomarkers: Triple-negative breast cancer; no inherited cancer gene mutation found.

As of February 2025, Kelly identified as a Stage IIIC triple-negative breast cancer survivor after neoadjuvant chemotherapy, double mastectomy with reconstruction, and radiation, and was using her experience to support others through TNBC Thrivers.

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Metastatic Breast Cancer Returning About 20 Years After Initial Treatment

Patient Info: Anonymized, Female | Stage IV

Biomarkers: ER-positive, PR-negative, HER2-positive

Metastatic Site: bones

About 20 years after her original breast-cancer treatment and sustained remission, bone biopsy confirmed metastatic recurrence; she became too unwell for planned cancer therapy and chose supportive care.

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Breast cancer survivor with synchronous intercostal nerve schwannomas mimicking metastasis

Patient Info: Anonymized, Female, Under 40

Biomarkers: Breast cancer biomarkers not reported; schwannomas were S100-positive

After prior breast cancer treatment, later D6-D7/rib lesions were proven to be S100-positive schwannomas rather than metastases, and surgical removal relieved the patient’s rib-cage numbness and pain.

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Stage 4 hormone receptor-positive breast cancer: remission with PARP inhibitor

Patient Info: Anonymized, Female, 40s | Stage IV

Biomarkers: HR-positive breast cancer with HER2-low/negative recurrence, and pathogenic BRCA2 R2318* mutation.

Metastatic Site: pleura

As of January 2025, she had maintained complete response for 36 months after sequential FEC/docetaxel and olaparib for hormone receptor-positive, HER2-negative/HER2-low metastatic breast cancer with BRCA2 R2318* mutation.

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Breast Cancer Recurring Years Later With Leptomeningeal Spread and a Brief Response to Trastuzumab Deruxtecan

Patient Info: Anonymized, Female, 60s | Stage IV

Biomarkers: ER-positive, PR-positive, HER2-low

Metastatic Site: peritoneum, retroperitoneum, bones, leptomeninges

Died on May 10, 2024, about 18 years after her April 2006 breast-cancer diagnosis and about 6 years after metastatic recurrence.

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Stage II HR-Positive Invasive Lobular Carcinoma: Karen's Survivor Story

Patient Info: Karen, Female, 40s | Stage II

Biomarkers: ER-positive; PR-positive; HER2-negative; grade 2; inherited genetic testing negative

Karen completed double mastectomy, 3 months of chemotherapy and reconstruction. She was doing well on ongoing endocrine and targeted therapy and walking 3–5 miles daily.

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Stage 3B breast cancer: partial mastectomy with pulmonary complications

Patient Info: Anonymized, Female, 70+ | Stage III

Partial mastectomy was completed for local control of bleeding/anemia in Stage IIIB breast cancer; she was discharged on postoperative day 7 without complications, but long-term cancer control was not reported.

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Breast Cancer Followed by a Separate Pleural Mesothelioma

Patient Info: Anonymized, Female, 40s

Follow-up imaging after breast-cancer treatment showed no regrowth before a separate pleural mesothelioma was diagnosed.

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Stage I ER-positive/HER2-positive breast cancer with radiation-associated morphea

Patient Info: Anonymized, Female, 70+ | Stage I

Biomarkers: ER-positive; PR-negative; HER2-positive

No evidence of breast cancer recurrence after 2018 treatment; ongoing issue was generalized morphea and breast deformity related to prior radiation, improved with mycophenolate by April 2024.

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