Treating Breast Asymmetry After Breast Cancer Surgery and Radiation

Patient Info: Anonymized, Female, 50s

By February 2024, about 2 years after breast-cancer surgery and radiation, she had completely recovered from the oncological condition.

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Two sisters with invasive lobular breast cancer and a shared CDH1 mutation

Patient Info: Anonymized, Female | Stage Metastatic/Advanced

Biomarkers: Both sisters had pathogenic CDH1 p.. Breast cancers were HER2-negative; older sister also had a PTCH1 variant of uncertain significance.

As of January 2025, both sisters were under ongoing hereditary diffuse gastric cancer surveillance with annual EGD after breast cancer treatment; no signs of HDGC or metastatic breast cancer were reported.

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Stage IV luminal B HER2-negative breast cancer with liver-limited metastasis resected after systemic therapy

Patient Info: Anonymized, Female, 40s | Stage IV

Biomarkers: Luminal B; HER2-negative

Metastatic Site: liver

After liver segmentectomy for breast-cancer liver metastasis, follow-up imaging showed no remaining liver nodes, and she remained fit, well, disease-free, and on maintenance letrozole plus goserelin.

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Triple-Negative Breast Cancer: Marissa's Survivor Story

Patient Info: Marissa Sweitzer, Female, Under 40

Biomarkers: ER-negative; PR-negative; HER2-negative; no breast cancer genetic mutation reported

As of December 2024, Marissa had a complete response to treatment and no evidence of cancer after postpartum triple-negative breast cancer involving the breast and lymph nodes was treated with chemotherapy, double mastectomy and 5 weeks of radiation.

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Stage 4 HR-positive breast cancer: stable disease on ribociclib

Patient Info: Anonymized, Female, 40s | Stage IV

Biomarkers: ER-positive; PR-positive; HER2-negative

Metastatic Site: left iliac bone

Metastatic HR-positive, HER2-negative breast cancer remained without progression as of October 2024 while she continued ribociclib 400 mg plus letrozole after SBRT to a left iliac bone metastasis.

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Triple-Negative Breast Cancer: Juliette's Survivor Story

Patient Info: Juliette Landgrave, Female, Under 40

Biomarkers: ER-negative; PR-negative; HER2-negative

After egg preservation, 16 rounds of chemotherapy with complete response, lumpectomy, 25 radiation sessions and 1 year of immunotherapy, Juliette was cancer-free as of December 2024.

City of HopeRead more →

Breast Cancer: Anna's Survivor Story

Patient Info: Anna, Female, Under 40

As of December 2024, Anna was about 7 years beyond her breast cancer diagnosis and living in survivorship, with ongoing emotional, fertility and family impacts described.

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Breast Cancer Recurrence in the Small Intestine and Bone More Than 5 Years After Diagnosis

Patient Info: Anonymized, Female, 50s | Stage IV

Biomarkers: Initial ER-positive, PR-positive, HER2-negative; metastatic lesion ER-negative, PR-negative, triple negative

Metastatic Site: small intestine, bone, right fallopian tube

More than 5 years after her December 2018 diagnosis, she was alive at 1-year follow-up after metastatic recurrence, with multiple bone metastases still present.

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Stage IV Breast Cancer: Nina's Survivor Story

Patient Info: Nina, Female, Under 40 | Stage IV

Metastatic Site: Spine

As of November 2024, Nina had Stage IV metastatic breast cancer with prior spine metastasis, remained on indefinite infusions and medications, and had current scans showing no evidence of disease.

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Rare squamous cell breast cancer: tumorectomy and partial mastectomy

Patient Info: Anonymized, Female, 40s | Stage I

Biomarkers: ER-negative; PR-negative; HER2-negative; Ki-67 21%, triple negative

As of August 2024, she had no recurrence 4 years after surgery, adjuvant AC/docetaxel chemotherapy, and residual breast irradiation for Stage I squamous cell carcinoma of the breast arising in a benign phyllodes tumor.

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Stage IIIA HR-positive HER2-negative breast cancer with radiation-induced brachial plexopathy

Patient Info: Anonymized, Female, 50s | Stage I

Biomarkers: HR-positive/HER2-negative breast cancer with pathogenic ATM and PALB2 variants plus an ATM VUS.

Approximately 3.5 years after radiation therapy, there was no evidence of breast cancer recurrence, but severe radiation-induced brachial plexopathy, fibrosis, telangiectasias, and lymphedema-related symptoms required ongoing supportive care.

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Stage IV HER2-Positive Breast Cancer: Nina's Survivor Story

Patient Info: Nina, Female, Under 40 | Stage IV

Biomarkers: HER2-positive; broad hereditary genetic testing negative

Metastatic Site: spine

As of November 2024, Nina described being in a no-evidence-of-disease phase, while continuing treatment because of her Stage IV HER2-positive metastatic breast cancer history.

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Breast invasive lobular carcinoma metastatic to the endometrium: hysterectomy and hormone therapy

Patient Info: Anonymized, Female, 50s | Stage IV

Biomarkers: HER2 negative, PR/HER2 negative.

Metastatic Site: endometrium (endometrial polyp)

No signs of recurrence were reported 18 months after total hysterectomy with bilateral adnexectomy for endometrial metastasis from invasive lobular breast carcinoma, with scheduled follow-up every 3 to 6 months.

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Stage II Invasive Ductal Carcinoma: Lauren's Survivor Story

Patient Info: Lauren, Female | Stage II

As of November 2024, Lauren had completed surgery, chemotherapy, and 25 rounds of radiation for Stage II invasive ductal breast cancer and was moving into survivorship.

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Triple-Negative Breast Cancer in a Young Woman With Bloom Syndrome Followed by Myelodysplastic Syndrome

Patient Info: Anonymized, Female, Under 40

Biomarkers: Triple-negative

Follow-up imaging after breast-cancer treatment showed no malignant lesions. Eight months after treatment, she developed myelodysplastic syndrome with excess blasts and later died from sepsis at age 33.

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HR-Positive Breast Cancer: Anna's Survivor Story

Patient Info: Anna, Female, Under 40

Biomarkers: ER-positive; PR-positive; HER2-positive

As of October 2024, Anna was about 7 years from diagnosis and described long-term survivorship after surgery, chemotherapy, radiation, biologic treatment, and tamoxifen-related mental-health effects.

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Anna’s Triple-Positive Breast Cancer Story

Patient Info: Anna, Female, Under 40

Biomarkers: ER-positive, PR-positive and HER2-positive

Anna completed surgery, chemotherapy and radiation and continued to navigate the effects of hormone therapy, early menopause and fertility loss.

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Breast Cancer: Francina's Survivor Story

Patient Info: Francina, Female

Biomarkers: Biomarker testing performed; specific markers not reported

As of October 2024, Francina described herself as 6.5 years cancer-free after surgery, chemotherapy, radiation, and biomarker-guided treatment planning.

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Triple-Negative Breast Cancer: Erica's Survivor Story

Patient Info: Erica Watson, Female, 50s

Biomarkers: ER-negative; PR-negative; HER2-negative

As of October 2024, Erica had no evidence of disease after triple-negative breast cancer showed a complete response to 16 chemotherapy treatments, lumpectomy, reconstructive surgery and 15 rounds of radiation.

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Stage IV HR-Positive Invasive Ductal Carcinoma: Dee's Patient Story

Patient Info: Dee, Female, Under 40 | Stage IV

Biomarkers: ER-positive

Metastatic Site: Bones

As of October 2024, Dee was living with Stage IV metastatic ER-positive breast cancer after bone metastases were found in 2023 and had adapted to treatment with ribociclib.

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Invasive Ductal Carcinoma: Lauren's Survivor Story

Patient Info: Lauren O'Connell, Female

As of September 2024, Lauren had completed lumpectomy, chemotherapy, and 25 rounds of radiation. She described major emotional change and recovery, but no formal NED or cancer-free status was reported.

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Stage IV HER2-Positive Invasive Ductal Carcinoma: Dee's Patient Story

Patient Info: Dee Doherty, Female, Under 40 | Stage IV

Biomarkers: Hormone-sensitive disease implied by letrozole and ovarian suppression; ER/PR/HER2 status not explicitly stated

Metastatic Site: bone

As of September 2024, Dee was living with Stage IV metastatic breast cancer. Her tumors had not shrunk, but disease was stable on ribociclib/Kisqali, letrozole, and ovarian suppression.

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Stage III HER2-Positive Occult Breast Cancer With a Complete Response to Treatment

Patient Info: Anonymized, Female, 40s | Stage III

Biomarkers: HER2-positive

Surgery after neoadjuvant treatment found no residual tumor in the breast or 20 examined lymph nodes, indicating a complete pathologic response; HER2-targeted therapy continued afterward.

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Stage II HER2-Positive Breast Cancer With Fever and a Reversible Brain MRI Lesion After Radiotherapy

Patient Info: Anonymized, Female, Under 40 | Stage II

Biomarkers: ER-positive, PR-positive, HER2-positive

After radiotherapy, fever, neutropenia, headache, and a reversible splenial brain lesion resolved with supportive and antibiotic treatment during her postoperative breast-cancer treatment course.

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