A New Mass Three Years After Lumpectomy Was Fat Necrosis

Patient Info: Anonymized, Female, 50s

Biomarkers: ER-positive; PR-positive; HER2-negative.

A new mass detected three years after treatment was biopsy-proven fat necrosis rather than recurrent cancer.

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Locally advanced male breast cancer associated with a pathogenic ATM variant

Patient Info: Anonymized, Male, 50s | Stage Metastatic/Advanced

Biomarkers: ER 100% positive; PR 100% positive; HER2-negative; Ki-67 30%; germline pathogenic ATM variant c.2921+1G>A.

Two years after diagnosis, he had an ECOG performance status of 0 and remained without signs of breast-cancer relapse or another primary cancer.

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Breast Cancer Recurrence Treated With Radiation Despite a Chronic Skin Condition

Patient Info: Anonymized, Female, 50s

Biomarkers: ER-positive; PR-positive; HER2-negative

After treatment of a chest-wall recurrence and a radiographically suspicious ischial lesion, she completed chest-wall radiation, her skin healed within 5 weeks, and she remained under surgical, radiation-oncology, and dermatology review.

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Male breast cancer found after persistent nipple discharge without a lump

Patient Info: Anonymized, Male, 60s | Stage 0

Biomarkers: ER-positive; PR-positive

Six months after mastectomy, surveillance examination found no clinical evidence of recurrence.

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A New Breast Cancer Arising Beneath an Accessory Nipple

Patient Info: Anonymized, Female, 40s

Biomarkers: ER 5%; PR 5–10%; HER2-negative.

After chemotherapy, surgery, endocrine therapy, proton radiation, and later reconstruction revision, she was currently without evidence of disease.

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Lobular breast cancer later spread to the stomach, bone, neck and mediastinum

Patient Info: Anonymized, Female, 70+ | Stage IV

Biomarkers: ER-positive; PR-positive; HER2-negative

Metastatic Site: stomach|bone|neck|mediastinum

After gastric metastasis was diagnosed and later imaging showed bone, neck and mediastinal spread, her oral intake and health declined; she chose palliative care and died 7 months after the diagnostic endoscopy.

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Stage II HR-Positive Invasive Ductal Carcinoma: Caitlin's Patient Story

Patient Info: Caitlin J., Female, Under 40 | Stage II

Biomarkers: ER-positive; PR-positive; BRCA-negative

As of July 2020, Caitlin had completed lumpectomy, AC chemotherapy, Taxol, and 33 radiation treatments for Stage IIB ER-positive, PR-positive IDC and was continuing monthly Lupron plus daily anastrozole.

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Lobular Breast Cancer Spread Into a Nasal Tumor

Patient Info: Anonymized, Female, 60s | Stage IV

Biomarkers: Metastatic lobular focus: ER 8/8; PR 8/8; HER2-negative; E-cadherin-negative.

Metastatic Site: liver; bone; right nasal cavity within an olfactory…

The nasal lesion was removed with no residual local disease on imaging, and capecitabine was restarted while oncology follow-up continued for metastatic breast cancer.

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My Pink Genes

Patient Info: Anonymized, Under 40 | Stage III

Biomarkers: ER-negative; PR-positive; HER2-negative; pathogenic CDH1 variant

At age 32, a patient with Stage IIIA pleomorphic invasive lobular breast cancer learned of a pathogenic CDH1 variant linked to breast and gastric cancer risk.

Fatal Bowel Infection After the First Chemotherapy Cycle for Early HER2-Positive Breast Cancer

Patient Info: Anonymized, Female, 70+

Biomarkers: ER-positive; PR-positive; HER2-amplified

Nine days after the first TCH cycle, she developed fulminant febrile neutropenia and Clostridium septicum sepsis with extensive bowel ischaemia; despite emergency treatment and resuscitation, she died 4 hours after hospital arrival.

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Stage IV Breast Cancer: Kirby's Patient Story

Patient Info: Kirby Lewis, Male | Stage IV

Biomarkers: ER-positive, PR-positive, HER2-negative

Metastatic Site: lung|spine

Kirby was living with metastatic breast cancer, and his most recent scans showed the right-lung tumor was stable with no signs of progression while he continued fulvestrant and palbociclib.

A second breast cancer arising in a previously known cyst

Patient Info: Anonymized, Female, 70+

Biomarkers: ER >95% positive; PR >95% positive; HER2 negative; Ki-67 11–50%; p53 negative for overexpression

She completed right-breast radiation and was continuing anastrozole 1 mg daily as adjuvant endocrine therapy.

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Small hormone-receptor-positive breast cancer found incidentally on chest CT

Patient Info: Anonymized, Female, 70+

Biomarkers: ER 95% positive; PR 70% positive; HER2 negative; Ki-67 11–50%; p53 negative for overexpression

She was receiving adjuvant breast radiation, with at least 5 years of anastrozole planned afterward.

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Encapsulated papillary breast cancer in a 62-year-old man

Patient Info: Anonymized, Male, 60s

Biomarkers: ER 95% positive; PR 95% positive; HER2 negative; Ki-67 11–50%; p53 negative for overexpression; hereditary cancer panel negative for reported pathogenic mutations including BRCA1 and PALB2

Mastectomy removed a 2.4 cm encapsulated papillary carcinoma with clear margins and 0/3 sentinel nodes involved; systemic adjuvant therapy was not recommended.

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Rapidly enlarging breast cancer with suspected metaplastic features

Patient Info: Anonymized, Female, 40s

Biomarkers: ER 95% positive; PR 95% positive; HER2 negative; Ki-67 11–50%; p53 negative for overexpression

Further biopsy was pending, with neoadjuvant chemotherapy planned before definitive breast surgery.

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Early breast cancer followed 19 years later by a radiation-related breast sarcoma

Patient Info: Anonymized, Female, 70+ | Stage I

Biomarkers: Strongly ER-positive; strongly PR-positive.

The stage IA breast carcinoma remained disease-free for 19 years; a later right-breast mass was a separate radiation-induced sarcoma rather than recurrent carcinoma.

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Metastatic Breast Cancer Presenting With Severe Pulmonary Hypertension

Patient Info: Anonymized, Female, Under 40 | Stage IV

Biomarkers: ER-positive; PR-positive.

Metastatic Site: bone; bone marrow

At seven months, she was doing well with a marked response on PET imaging, normalized right-heart pressures, and ongoing systemic treatment with palbociclib.

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Breast Cancer Arising in Ectopic Tissue in the Armpit

Patient Info: Anonymized, Female, 40s

Biomarkers: ER positive; PR positive; HER2 negative

A 43-year-old woman’s presumed axillary cyst proved to be hormone-receptor-positive breast cancer arising in ectopic breast tissue.

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Stage II HR-Positive Breast Cancer: Cath's Survivor Story

Patient Info: Cath, Female, 60s | Stage II

Biomarkers: ER-positive; PR-positive; HER2-negative

Cath was declared cancer-free in June 2024 after Stage II luminal A ER-positive/PR-positive/HER2-negative breast cancer treated with surgery, radiation, and hormone therapy, though she continued to manage long-term side effects and recurrence fear.

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Splenectomy Reduced Transfusion Needs in Metastatic Lobular Breast Cancer

Patient Info: Anonymized, Female, 40s | Stage Metastatic/Advanced

Biomarkers: ER positive; PR positive; HER2 negative

Metastatic Site: skin|bone|bone marrow|spleen

She remained independent through her last oncology visit 18 months after splenectomy and died 1 month later.

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Lobular Breast Cancer Spreading to an Eye Muscle

Patient Info: Anonymized, Female, 40s | Stage Metastatic/Advanced

Biomarkers: Hormone receptor-positive; HER2-negative; E-cadherin-negative; CK7-positive

Metastatic Site: bones|left superior oblique eye muscle

The eye-muscle metastasis entered complete local remission, while bone disease was stable after 6 months of weekly paclitaxel and denosumab.

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Occult lobular breast cancer presenting as an orbital metastasis

Patient Info: Anonymized, Female, 60s | Stage IV

Biomarkers: ER positive; PR positive; HER2 negative; CK7 positive; CK CAM5.2 positive; E-cadherin negative

Metastatic Site: left orbit, bone

The orbital metastasis decreased with treatment and systemic disease remained controlled on hormonal therapy during 5 years of clinical follow-up.

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Triple receptor-positive neuroendocrine breast cancer in a 32-year-old woman

Patient Info: Anonymized, Female, Under 40 | Stage III

Biomarkers: ER positive; PR positive; HER2 positive; neuron-specific enolase positive; synaptophysin positive

She was stable on follow-up and was receiving adjuvant chest-wall radiation plus systemic chemotherapy and trastuzumab-based therapy.

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Breast cancer returning 21 years later as a solitary parotid metastasis

Patient Info: Anonymized, Female, 70+ | Stage IV

Biomarkers: Parotid metastasis ER positive; PR positive; HER2 borderline by IHC but FISH 1.82

Metastatic Site: left parotid gland

More than 5 months after the parotid metastasis was diagnosed, the tumour had slightly decreased in size and her metastatic disease remained stable on endocrine therapy.

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