Locally advanced male breast cancer associated with a pathogenic ATM variant

Patient Info: Anonymized, Male, 50s | Stage Metastatic/Advanced

Biomarkers: ER 100% positive; PR 100% positive; HER2-negative; Ki-67 30%; germline pathogenic ATM variant c.2921+1G>A.

Two years after diagnosis, he had an ECOG performance status of 0 and remained without signs of breast-cancer relapse or another primary cancer.

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A durable response to trastuzumab in heavily pretreated metastatic breast cancer

Patient Info: Anonymized, Female, 60s | Stage IV

Biomarkers: Initial tumor ER-positive and PR-positive. Metastatic liver biopsy ER-negative and PR-negative with HER2 IHC 1+ and nonamplified. Later biopsy ER and PR weakly positive at 5%–10%, HER2 IHC 1+ and nonamplified, and ERBB3 p. with evidence of HER2/HER3 pathway activation.

Metastatic Site: lungs; hilar and mediastinal lymph nodes; liver; bone

She had ongoing benefit for more than 10 months on trastuzumab and capecitabine, with improved symptoms, lower tumor markers, and a confirmed partial response.

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Stage II Breast Cancer: Amanda's Patient Story

Patient Info: Amanda, Female, 40s | Stage II

As of 2021, Amanda was on hormone therapy for Stage II breast cancer, managing fatigue, nausea/vomiting, and peripheral neuropathy while working through financial and fertility-related concerns.

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Stage II Breast Cancer: Marisol's Survivor Story

Patient Info: Marisol | Stage II

Marisol said the breast cancer was in remission after completing most active treatment, and she continued hormone therapy.

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Stage II Breast Cancer: Hwee's Patient Story

Patient Info: Hwee Lin, Female, 60s | Stage II

Hwee Lin was receiving targeted therapy for Stage II breast cancer and described the treatment as effective while managing fatigue, hair loss, nausea, and vomiting with medication and improved nutrition.

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Breast Cancer: Luz's Survivor Story

Patient Info: Luz

Luz described her breast cancer as being in remission after mastectomy, lymph-node surgery, and chemotherapy, and she remained on hormone therapy.

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Breast Cancer: Martha's Survivor Story

Patient Info: Martha

Martha said the breast cancer was in remission while she continued Letrozol hormone therapy.

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Stage II Breast Cancer: Sheryl's Patient Story

Patient Info: Sheryl | Stage II

Sheryl is currently receiving long-term hormone therapy and remains focused on becoming cancer-free.

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Stage I Breast Cancer: Stella's Patient Story

Patient Info: Stella | Stage I

She is in remission after surgery and chemotherapy and remains on hormone therapy.

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Stage I Breast Cancer: Melissa's Patient Story

Patient Info: Melissa | Stage I

Melissa was in remission and continued hormone therapy while managing fear of recurrence.

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Ana's Stage 2 Breast Cancer and Cancer-Free Milestone

Patient Info: Ana, Female, 50s | Stage II

Ana completed intensive multimodal treatment and was declared cancer-free in 2024. She continued Tamoxifen as a planned 5-year hormone-therapy course.

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Stage III Breast Cancer: Blanca's Patient Story

Patient Info: Blanca, Female, 50s | Stage III

As of 2021, Blanca had completed active treatment, had not received radiation therapy, and remained on hormone therapy while rebuilding daily life and family routines.

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Cherie's Stage 2 Breast Cancer Story After a Second Opinion

Patient Info: Cherie, Female, 50s | Stage II

Cherie described herself as being in remission while continuing hormone therapy. She remained concerned about relapse and used travel and painting to manage anxiety.

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Breast Cancer: Olive's Survivor Story

Patient Info: Olive

Her breast cancer was in remission, although she remained on hormonal therapy and continued managing fatigue, weight changes, and recurrence anxiety.

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Breast Cancer: Vivienne's Survivor Story

Patient Info: Vivienne

Vivienne said she was in remission after completing most of her treatment and continued hormone therapy.

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Stage III Breast Cancer: Alexandra's Patient Story

Patient Info: Alexandra, Female, 40s | Stage III

As of 2021, Alexandra was living with Stage III breast cancer and continuing chemotherapy after treatment with docetaxel, carboplatin, antibody drug conjugates, and tamoxifen.

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Breast Cancer Recurrence Treated With Radiation Despite a Chronic Skin Condition

Patient Info: Anonymized, Female, 50s

Biomarkers: ER-positive; PR-positive; HER2-negative

After treatment of a chest-wall recurrence and a radiographically suspicious ischial lesion, she completed chest-wall radiation, her skin healed within 5 weeks, and she remained under surgical, radiation-oncology, and dermatology review.

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Occult lobular breast cancer first discovered through colon metastases

Patient Info: Anonymized, Female, 70+ | Stage IV

Biomarkers: ER-positive; PR-negative; HER2-negative; E-cadherin-negative

Metastatic Site: colon

Her tumour marker decreased during letrozole and palbociclib treatment, but recurrent infections interrupted therapy, and she died from urosepsis 2 years after diagnosis.

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Male breast cancer found after persistent nipple discharge without a lump

Patient Info: Anonymized, Male, 60s | Stage 0

Biomarkers: ER-positive; PR-positive

Six months after mastectomy, surveillance examination found no clinical evidence of recurrence.

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Stage I Breast Cancer: Deborah's Patient Story

Patient Info: Deborah Brown, Female, 60s | Stage I

As of October 2020, Deborah had completed lumpectomy and 5 focused radiation treatments for Stage I breast cancer and remained on oral hormone therapy; chemotherapy was not needed and recurrence status was not otherwise stated.

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Stage IV Breast Cancer: Pam's Patient Story

Patient Info: Pam Benchley, Female, 50s | Stage IV

Biomarkers: Not explicitly reported; treated with anti-estrogen therapy and a CDK4/6 inhibitor

Metastatic Site: Liver

As of October 2020, Pam had responded favorably to anti-estrogen therapy plus a CDK4/6 inhibitor, surgery, radiation and liver radiofrequency ablation; her oncologist described her as free of evidence of active cancer, while avoiding the term cancer-free for metastatic disease.

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Breast cancer treated with anastrozole after a separate advanced lung cancer diagnosis

Patient Info: Anonymized, Female, 60s

She received anastrozole for breast cancer while advanced lung cancer determined the immediate treatment course, and she later died after acute hypoxic respiratory failure.

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Stage IIIA Right Breast Cancer Followed by a Late Radiation Nerve Injury

Patient Info: Anonymized, Female, 50s | Stage III

Imaging in January 2019 found no evidence of breast-cancer recurrence, although she had developed radiation-induced brachial plexopathy.

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A New Breast Cancer Arising Beneath an Accessory Nipple

Patient Info: Anonymized, Female, 40s

Biomarkers: ER 5%; PR 5–10%; HER2-negative.

After chemotherapy, surgery, endocrine therapy, proton radiation, and later reconstruction revision, she was currently without evidence of disease.

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