Triple-Negative Breast Cancer: Robin's Survivor Story

Patient Info: Robin Roberts, Female

Biomarkers: Triple-negative breast cancer

As of February 2013, Robin was being honored as a triple-negative breast cancer survivor after going public, receiving chemotherapy, and returning to public life; no formal NED status was stated.

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ER-positive breast cancer recurrence with renal metastasis inside angiomyolipoma

Patient Info: Anonymized, Female, 60s | Stage IV

Biomarkers: ER-positive; mammaglobulin-positive; e-cadherin-positive; GCDFP-15-positive; melan A positive in angiomyolipoma component

Metastatic Site: right subpectoral lymph node, left kidney

At 7 months after nephrectomy, she continued anti-estrogen hormonal therapy with no demonstrable progression of disease; surgical excision of the subpectoral lymph node was offered but declined.

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BRCA1-associated right invasive ductal carcinoma followed by left acinic cell carcinoma of the breast

Patient Info: Anonymized, Female, 40s

Biomarkers: Constitutional BRCA1 mutation. Right breast cancer was ER/PR positive, HER2 negative; later left tumor was triple-negative with TP53 change.

After treatment for right invasive ductal carcinoma and later contralateral acinic cell carcinoma, she was alive and well 19 months after the acinic cell carcinoma surgery, with no evidence of disease while continuing hormonal therapy.

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ER/PR-positive breast cancer with bilateral ovarian metastases controlled after oophorectomy and aromatase inhibitor

Patient Info: Anonymized, Female, 50s | Stage IV

Biomarkers: ER-positive; PR-positive; HER2-negative; CK7-positive; gross cystic disease fluid protein-15-positive; CK20-negative

Metastatic Site: bilateral ovaries

After bilateral oophorectomies and aromatase inhibitor therapy, pleural effusion resolved, CEA and CA 15-3 decreased below the normal upper limit, and she remained well with no further recurrence for 40 months.

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Metastatic lobular breast cancer to gynecologic sites: disease-free after surgery and chemotherapy

Patient Info: Anonymized, Female, 50s | Stage IV

Biomarkers: ER-positive; PR-negative; HER2/C-Erb-B2-negative

Metastatic Site: vagina, uterus, ovaries

After treatment of vaginal, uterine, and ovarian metastases from lobular breast cancer, she was free from disease 12 months after completion surgery.

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Hormone-positive breast cancer with axillary recurrence responding to hyperthermia, radiation, and chemotherapy

Patient Info: Anonymized, Female, 60s

Biomarkers: ER-positive; PR-positive; HER2-negative

The left axillary recurrence enlarged during weekly paclitaxel and radiotherapy, then became nearly flat and was assessed as a complete response 8 weeks after adding hyperthermia.

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Stage III Triple-Negative Breast Cancer: Bridgette's Survivor Story

Patient Info: Bridgette, Female, 60s | Stage III

Biomarkers: Triple-negative breast cancer

Bridgette completed treatment and described herself as being in remission and free of cancer. Fear of recurrence continued to affect her survivorship.

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Recurrent HER2-amplified breast cancer: complete remission on trastuzumab-based therapy

Patient Info: Anonymized, Female, 40s | Stage Metastatic/Advanced

Biomarkers: Primary tumor was ER/PR negative and HER2 not amplified. Recurrent lymph-node disease became ER/PR positive and HER2 amplified by FISH.

Metastatic Site: left axillary and infraclavicular lymph nodes

After HER2-amplified nodal recurrence, paclitaxel plus trastuzumab produced complete clinical remission; she continued trastuzumab monotherapy with tolerable neuropathy.

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Right breast ductal carcinoma with unusual sentinel-node drainage treated with lumpectomy and adjuvant therapy

Patient Info: Anonymized, Female, 40s

After lumpectomy, negative sentinel lymph node evaluation across 3 drainage territories, chemotherapy, radiotherapy, and hormone therapy, she remained free of disease 2 years and 6 months after surgery.

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Lobular breast cancer with extraocular muscle and lung metastases: ocular improvement after radiotherapy and tamoxifen

Patient Info: Anonymized, Female, 60s | Stage IV

Biomarkers: Original breast cancer: ER-negative; PR-negative. Extraocular muscle metastasis/recurrent disease: ER strongly positive; PR strongly positive.

Metastatic Site: bilateral extraocular muscles, right upper lobe lung,…

At 18 months after presentation with extraocular muscle metastases, PET showed no abnormality, diplopia had resolved, and ocular motility had markedly improved, with mild bilateral ptosis remaining.

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Triple-negative glycogen-rich clear cell carcinoma of the breast: chemotherapy, mastectomy, and radiation

Patient Info: Anonymized, Female, 50s | Stage III

Biomarkers: Triple-negative breast cancer with glycogen-rich clear cell features; pathology stains supported breast carcinoma.

Asymptomatic and disease-free 14 months after surgery, additional chemotherapy, and 50 Gy radiotherapy for T4N0M0 triple-negative glycogen-rich clear cell breast carcinoma.

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ER-positive breast cancer recurrence after DCIS: chemotherapy, nodal surgery, radiation, and endocrine therapy

Patient Info: Anonymized, Female, 40s

Biomarkers: Recurrent invasive breast cancer: ER-positive; HER2/neu-negative. PR not reported.

Disease-free for 33 months after treatment of ER-positive, HER2-negative invasive breast cancer recurring in the mastectomy skin flap with positive axillary sentinel nodes.

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Localized breast carcinosarcoma: surgery and chemotherapy with no disease at 54 months

Patient Info: Anonymized, Female, 40s

Biomarkers: Breast carcinosarcoma was ER/PR negative, c-erbB2 5%

Under follow-up with no disease at 54 months after excision, modified radical mastectomy, and 6 courses of chemotherapy for localized breast carcinosarcoma.

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HER2-positive breast cancer with isolated adrenal metastasis: adrenalectomy with no recurrence at follow-up

Patient Info: Anonymized, Female, 60s | Stage IV

Biomarkers: Primary breast tumor and adrenal metastasis were HER2-positive and ER/PR negative; adrenal markers supported breast origin.

Metastatic Site: left adrenal gland

Alive in good condition with no evidence of recurrence more than 3 years after adrenalectomy for isolated adrenal metastasis and more than 5 years after the original breast surgery.

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Stage I BRCA1 Breast Cancer: Karen's Patient Story

Patient Info: Karen | Stage I

Biomarkers: BRCA1 mutation

Karen completed surgery and chemotherapy for stage 1 breast cancer and chose prophylactic bilateral mastectomy because of a BRCA1 mutation, while continuing to live with fear of recurrence.

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Stage II Breast Cancer: Martha's Survivor Story

Patient Info: Martha | Stage II

Martha completed treatment and said she had been declared cancer-free, 14 years after her stage II diagnosis.

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Stage 0 Breast Cancer: Linda's Survivor Story

Patient Info: Linda | Stage 0

Linda completed lumpectomy, chemotherapy, and radiation after a stage 0 diagnosis in 2007 and described the cancer as being in remission years later.

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Stage III Breast Cancer: Mary's Survivor Story

Patient Info: Mary | Stage III

Mary said she was in remission and no longer required cancer treatment.

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