Stage III Invasive Lobular Carcinoma: Barb's Survivor Story

Patient Info: Barb, Female | Stage III

As of December 2020, Barb was in survivorship after bilateral mastectomy, chemotherapy, radiation, and 2 reconstruction revision surgeries for Stage III invasive lobular breast cancer.

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Breast Adenoid Cystic Carcinoma Treated With Mastectomy and Chemotherapy

Patient Info: Anonymized, Female

She remained recurrence-free through the follow-up period ending in June 2020.

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Breast Adenoid Cystic Carcinoma Treated With Breast-Conserving Surgery

Patient Info: Anonymized, Female

She remained recurrence-free through the follow-up period ending in June 2020.

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HER2-positive breast cancer diagnosed during pregnancy and later spread to bone and brain

Patient Info: Anonymized, Female, Under 40 | Stage IV

Biomarkers: Initial tumour: ER 0%, PR <1%, HER2 3+

Metastatic Site: bone (L3)|brain

After treatment and surveillance without new lesions, she developed a large symptomatic occipital brain metastasis 14 months after completing paclitaxel and radiation and died after rapid neurological deterioration.

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Stage II Triple-Negative Breast Cancer: Jessica's Survivor Story

Patient Info: Jessica Duemig, Female, Under 40 | Stage II

Biomarkers: ER-negative; PR-negative; HER2-negative

As of October 2020, Jessica had been considered cured since February 2020 after treatment for Stage IIA triple-negative metaplastic breast cancer and was described as living life to the fullest about 3 years after diagnosis.

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Triple-Negative Breast Cancer Treated With Mastectomy and Chemotherapy

Patient Info: Anonymized, Female, 40s

Biomarkers: Triple-negative.

The later accessory-breast-tissue cancer was considered a separate new primary after a five-year interval, and she was currently without evidence of disease.

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A New Breast Cancer Arising Beneath an Accessory Nipple

Patient Info: Anonymized, Female, 40s

Biomarkers: ER 5%; PR 5–10%; HER2-negative.

After chemotherapy, surgery, endocrine therapy, proton radiation, and later reconstruction revision, she was currently without evidence of disease.

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Stage IIIA Right Breast Cancer Followed by a Late Radiation Nerve Injury

Patient Info: Anonymized, Female, 50s | Stage III

Imaging in January 2019 found no evidence of breast-cancer recurrence, although she had developed radiation-induced brachial plexopathy.

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HER2-Positive Breast Cancer Linked to a Rare Immune-Related Neurological Syndrome

Patient Info: Anonymized, Female, 40s

Biomarkers: HER2-positive in both foci; one focus ER-negative/PR-positive with Ki-67 45%; second focus ER-negative/PR-negative with Ki-67 35%; anti-Yo antibodies positive in serum and CSF; tumour-susceptibility gene panel negative

At 1 year, she had completed trastuzumab, continued tamoxifen, and had no evidence of recurrent breast cancer; intensive rehabilitation improved her mobility, although balance and right-sided neurological deficits persisted.

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Stage IV Breast Cancer: Doris's Patient Story

Patient Info: Doris, Female | Stage IV

Metastatic Site: lungs

As of August 2020, Doris was living with Stage IV breast cancer metastatic to the lungs after chemotherapy and bilateral mastectomies, and the story asked for help so she could continue treatment.

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Recurrent Breast Cancer With a Benign-Appearing Chest-Wall Rash

Patient Info: Anonymized, Female | Stage IV

Biomarkers: Initial tumor: ER-positive; PR-negative; HER2-negative.

Metastatic Site: mediastinal lymph nodes

She had recurrent chest-wall and mediastinal metastatic disease; a later rash biopsy showed dermatitis rather than another skin recurrence.

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Heart Failure and Electrical Conduction Changes During Trastuzumab Treatment

Patient Info: Anonymized, Female, 70+

Biomarkers: HER2-positive; ER-positive

Trastuzumab was suspended after acute heart failure and electrical conduction abnormalities; 4 weeks later, left ventricular function recovered and the ECG returned to normal during cardio-oncology follow-up.

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Young woman with ductal breast cancer and bleeding gastric metastases

Patient Info: Anonymized, Female, Under 40 | Stage IV

Biomarkers: ER-positive; PR-negative; HER2-negative

Metastatic Site: pancreas|liver|kidney|stomach

After rapid progression to the pancreas, liver, kidney and stomach, she chose palliative care and died 1 month after presenting with gastrointestinal bleeding.

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Stage II HR-Positive Invasive Ductal Carcinoma: Caitlin's Patient Story

Patient Info: Caitlin J., Female, Under 40 | Stage II

Biomarkers: ER-positive; PR-positive; BRCA-negative

As of July 2020, Caitlin had completed lumpectomy, AC chemotherapy, Taxol, and 33 radiation treatments for Stage IIB ER-positive, PR-positive IDC and was continuing monthly Lupron plus daily anastrozole.

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Lobular Breast Cancer Spread Into a Nasal Tumor

Patient Info: Anonymized, Female, 60s | Stage IV

Biomarkers: Metastatic lobular focus: ER 8/8; PR 8/8; HER2-negative; E-cadherin-negative.

Metastatic Site: liver; bone; right nasal cavity within an olfactory…

The nasal lesion was removed with no residual local disease on imaging, and capecitabine was restarted while oncology follow-up continued for metastatic breast cancer.

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Bilateral Triple-Negative Breast Cancer Followed by Blood Clots and a Spinal-Fluid Leak

Patient Info: Anonymized, Female, 50s

Biomarkers: Triple-negative

Two years after chemotherapy, a recurrent cerebrospinal-fluid leak was repaired endoscopically and had not recurred at 12 months.

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Fatal Bowel Infection After the First Chemotherapy Cycle for Early HER2-Positive Breast Cancer

Patient Info: Anonymized, Female, 70+

Biomarkers: ER-positive; PR-positive; HER2-amplified

Nine days after the first TCH cycle, she developed fulminant febrile neutropenia and Clostridium septicum sepsis with extensive bowel ischaemia; despite emergency treatment and resuscitation, she died 4 hours after hospital arrival.

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Stage IV Invasive Ductal Carcinoma: Kristine's Patient Story

Patient Info: Kristine, Female | Stage IV

Metastatic Site: Lymph nodes; chest wall; upper lungs

As of May 2020, Kristine was living with recurrent metastatic breast cancer involving lymph nodes, chest wall and upper lungs, after surgery and radiation, with daily oral chemotherapy helping keep cancer controlled.

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Occult breast cancer found in the axillary lymph nodes during diagnosis of four cancers

Patient Info: Anonymized, Female, 70+

Biomarkers: ER 90% positive; HER2 overexpression; CK19-positive; mammaglobin-positive.

Almost four years after the synchronous cancer diagnoses, she was alive without recurrence and continued letrozole and oncology follow-up.

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Stage IV HER2-Positive Breast Cancer: Christine's Survivor Story

Patient Info: Christine Hodgdon, Female, Under 40 | Stage IV

Biomarkers: HER2-positive

Christine had no evidence of disease after 1 year and continued HER2-targeted treatment with regular surveillance scans.

Early metaplastic breast cancer treated alongside a separate lung cancer

Patient Info: Anonymized, Female, 60s | Stage I

Biomarkers: ER-negative; PR-negative; HER2-negative.

At 24 months, breast MRI showed no recurrent breast cancer after surgery and six cycles of paclitaxel and carboplatin.

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Stage IV Triple-Negative Breast Cancer: Eva's Patient Story

Patient Info: Eva Joseph | Stage IV

Biomarkers: Triple-negative

Metastatic Site: lungs, sternum

On ongoing atezolizumab plus nab-paclitaxel, Eva’s lung and sternum tumors became very small and were being kept at bay while she felt well enough to enjoy short trips.

Stage IV Breast Cancer: Kirby's Patient Story

Patient Info: Kirby Lewis, Male | Stage IV

Biomarkers: ER-positive, PR-positive, HER2-negative

Metastatic Site: lung|spine

Kirby was living with metastatic breast cancer, and his most recent scans showed the right-lung tumor was stable with no signs of progression while he continued fulvestrant and palbociclib.

Stage III Breast Cancer: Christine's Survivor Story

Patient Info: Christine Cosby | Stage III

At the latest report, there was no sign of cancer in Christine’s body and she had recovered enough to return to work part time.