Metastatic Colorectal Cancer With Leucovorin Hypersensitivity During Cetuximab-FOLFOX Treatment

Patient Info: Anonymized, female, 60s | Stage IV

Biomarkers: EGFR mutation detected; no KRAS, NRAS or BRAF mutations detected

Metastatic Site: lung

After 18 cycles of cetuximab plus FOLFOX, her metastatic colorectal cancer was stable and treatment continued with modifications for leucovorin hypersensitivity.

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Lung cancer first discovered through a skin metastasis

Patient Info: Anonymized, Male | Stage IV

Metastatic Site: skin and subcutaneous tissues; soft tissue and muscle;…

His metastatic disease progressed rapidly, and he died 4.5 months after the initial dermatology referral.

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Stage IV Colorectal Cancer: Jeff's Patient Story

Patient Info: Jeff Williams, Male, 50s | Stage IV

Metastatic Site: Liver; lungs

As of December 2023, Jeff was living with recurrent Stage IV colorectal cancer, had recently developed more lung tumors, continued chemotherapy locally every 2 weeks, and returned to UT MD Anderson every 3 months for scans.

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Metastatic gastric neuroendocrine carcinoma treated with repeated chemotherapy and immunotherapy

Patient Info: Anonymized, male, 60s | Stage IV

Biomarkers: HER2-negative

Metastatic Site: liver, pancreas

More than 3 years after diagnosis, he remained in good condition on fifth-line treatment. April 2023 CT showed shrinkage of liver and pancreatic-tail metastases.

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Colon cancer surgery complication: fistula after extensive pelvic surgery and radiation

Patient Info: Anonymized, Female | Stage IV

Metastatic Site: upper vaginal wall; lungs

She remained alive after treatment for metastatic colorectal cancer and recovered without clinical fistula recurrence at 1- and 2-month postoperative follow-up.

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Stage IV Breast Cancer: Kris's Patient Story

Patient Info: Kris Hallenga, Female, Under 40 | Stage IV

As of December 2023, Kris Hallenga had been living with Stage IV breast cancer for 14 years after diagnosis at age 23, while continuing her CoppaFeel advocacy and public work around living fully with advanced cancer.

Stage IV Colorectal Cancer: Dania's Patient Story

Patient Info: Dania, Female, Under 40 | Stage IV

Biomarkers: Not reported; pathology supported Keytruda eligibility

Metastatic Site: Liver; peritoneum

As of December 2023, Dania had Stage IV colon cancer but described an excellent response to Keytruda, successful colon/hernia surgery, and successful liver surgery while still healing and continuing follow-up.

The Patient StoryRead more →

Treatment-Refractory Triple-Negative Breast Cancer Treated With Tumor-Infiltrating Lymphocytes

Patient Info: Anonymized, female, Under 40 | Stage IV

Biomarkers: Germline BRCA1 pathogenic variant; later triple-negative phenotype

Metastatic Site: skin, lungs, bones

Tumor burden briefly decreased after tumor-infiltrating lymphocyte therapy, but she developed severe treatment complications followed by rapid cancer relapse and died about 1 month after the TIL/IL-2 treatment began.

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Breast Cancer Recurs After a 19-Year Remission and Responds to Later Chemotherapy

Patient Info: Anonymized, female, 50s | Stage IV

Biomarkers: Initial tumor: PR-positive, ER-negative, HER2-negative. Recurrence: ER-positive, PR-negative

Metastatic Site: bones

The cancer recurred after a 19-year remission and later spread to bone. More than 21 years after the original diagnosis, she had marked tumor shrinkage, was in good general condition, and had 10 months of progression-free survival after utidelone plus capecitabine.

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Male Breast Cancer Controlled for Years Through Multiple Lines of Targeted and Endocrine Therapy

Patient Info: Anonymized, male, 70+ | Stage IV

Biomarkers: Initial tumor ER-positive, PR-positive, HER2-positive; later ER-positive, PR-negative, HER2-negative; PIK3CA mutation; germline BRCA1/2 negative

Metastatic Site: bones, pleura, liver

After a 5-year and 6-month disease-free interval, the cancer recurred in bone and later progressed to the pleura and liver. He died in January 2021, more than 13 years after his 2007 breast-cancer diagnosis.

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Stage IV ALK Lung Cancer: Matt's Survivor Story

Patient Info: Matt Hiznay, Male, Under 40 | Stage IV

Biomarkers: ALK mutation / ALK-positive

Metastatic Site: Not reported

As of November 2023, Matt was a 12-year survivor with Stage IV ALK-positive lung cancer in remission, no evidence of disease, and ongoing lorlatinib treatment.

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Brain radiation therapy complication (radionecrosis) potentially linked to combined chemo-immunotherapy

Patient Info: Anonymized, Female | Stage IV

Biomarkers: PD-L1 0%; tumour mutational burden 33 mutations/Mb; TP53 mutation at diagnosis; later ctDNA included KEAP1 and NOTCH3 alterations

Metastatic Site: brain; presumed leptomeningeal disease

She recovered completely from surgery for radiation necrosis, resumed cancer treatment and remained neurologically intact at 18 months. She was found deceased 9 months later; the cause of death was unknown.

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Rare anorectal melanoma that spread to the liver, lungs, and lymph nodes

Patient Info: Anonymized, Male | Stage IV

Metastatic Site: liver; lungs; lymph nodes

Five months after completing treatment, he presented with severe respiratory distress and died 4 days later.

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Stage IV BRAF Colorectal Cancer: Loralee's Patient Story

Patient Info: Loralee Lovell, Female | Stage IV

Biomarkers: BRAF mutation; microsatellite stable

Metastatic Site: liver|lungs|lymph nodes|peritoneal lining

Loralee continued treatment for metastatic colon cancer for several years and died on May 26, 2026.

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Adenoid Cystic Breast Cancer Spreads to the Kidney, Lungs, Bone and Spleen

Patient Info: Anonymized, female, 70+ | Stage IV

Biomarkers: Triple-negative

Metastatic Site: kidneys, lungs, spleen, bone, lymph nodes

The cancer progressed from an initial kidney metastasis to widespread disease involving the lungs, spleen, right kidney, lymph nodes, and C4 vertebra. By May 2022 she had worsening cachexia and pain, and best supportive care was recommended.

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Male breast cancer in both breasts linked to Klinefelter syndrome, initially missed

Patient Info: Anonymized, Male | Stage IV

Biomarkers: ER-positive; PR-positive; HER2-negative; Klinefelter syndrome

Metastatic Site: spine / bone

With advanced metastatic disease and an estimated prognosis of weeks or less, care focused on symptom relief under the palliative-care team.

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Metastatic Breast Cancer Treatment Complicated by a Supplement–Drug Interaction

Patient Info: Anonymized, female, 50s | Stage IV

Biomarkers: ER-positive, PR-positive, HER2-negative

Metastatic Site: bones

She resumed ribociclib with letrozole after the supplement was discontinued and the treatment-related neutropenia improved enough to restart therapy.

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Stage IV Breast Cancer: Sherri's Patient Story

Patient Info: Sherri, Female | Stage IV

Biomarkers: BRCA1-negative

Metastatic Site: Bone marrow

As of November 2023, Sherri had no evidence of disease on recent breast cancer scans but remained on targeted treatment every 3 weeks and had started oxaliplatin after surgery for a separate Stage III colon cancer.

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Stage IV Inflammatory Breast Cancer: Corky's Patient Story

Patient Info: Corky, Female, 60s | Stage IV

Metastatic Site: Not reported

As of October 2023, Corky was living with Stage IV inflammatory breast cancer as a chronic condition, receiving ongoing treatment focused on prolonging life and preserving quality of life.

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Stage IV HER2-Positive Multiple primaries: metastatic Breast Cancer + Colon/Colorectal Cancer: Sherri's Patient Story

Patient Info: Sherri, Female | Stage IV

Biomarkers: HER2-positive breast cancer; colon cancer Signatera positive before surgery and negative after surgery

Metastatic Site: Bone marrow

As of October 2023, Sherri had no evidence of disease on recent scans for HER2-positive metastatic breast cancer but was receiving oxaliplatin/Oxyplatin chemotherapy and transfusions for a separate early Stage III colon cancer.

The Patient StoryRead more →

Metastatic breast cancer: three years in remission with T-DM1 (Kadcyla) treatment

Patient Info: Anonymized, Female | Stage IV

Biomarkers: HER2-positive; hormone receptor-positive

Metastatic Site: liver; spine / bone

T-DM1 produced a complete clinical and radiological response after 7 cycles, sustained for 41 months and 60 cycles while treatment continued.

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Stage IV ALK Non-Small Cell Lung Cancer: Christine's Patient Story

Patient Info: Christine, Female, 50s | Stage IV

Biomarkers: ALK mutation / ALK-positive

Metastatic Site: Brain | Liver

As of October 2023, Christine was living with Stage IV ALK-positive NSCLC that remained in check on targeted therapy after alectinib cleared brain and liver spots and lorlatinib continued, with significant chronic side effects.

Lung Cancer Research FoundationRead more →

Breast cancer lung metastasis treated with a minimally invasive freezing procedure

Patient Info: Anonymized, Female | Stage IV

Biomarkers: HER2-positive; ER-negative

Metastatic Site: lungs

Follow-up PET/CT at 3, 6, 9 and 12 months after cryoablation showed no progression or new lesions without systemic therapy.

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Stage IV HER2-Positive Inflammatory Breast Cancer: Olivia's Survivor Story

Patient Info: Olivia Franz, Female, Under 40 | Stage IV

Biomarkers: HER2-positive

Metastatic Site: Bones; distant lymph nodes

As of October 2023, Olivia continued to show no evidence of disease on scans while receiving maintenance trastuzumab and pertuzumab every 3 weeks and zoledronic acid every 3 months for bone health.

MD AndersonRead more →