Stage 4: 1,129 Real Stories

1,129 stories match stage 4. 777 of them mention chemotherapy.

Cancer Stories

Ivy, who was diagnosed with Stage IV Lung CancerLung Cancer

Stage IV EGFR Lung Cancer: Ivy's Survivor Story

Patient Info: Ivy E., Female, 40s | Stage IV

Biomarkers: EGFR mutation

Metastatic Site: Bone: elbow, cervical spine/neck, rib, pelvis; brain

As of January 2024, Ivy reported no evidence of disease 1 year after right upper lobectomy, after years of response to EGFR-targeted therapy for initially Stage IV lung cancer.

The Patient Story
OutcomeCancer-Free / NED
Cristina, who was diagnosed with Stage IV Colorectal CancerColorectal Cancer

Stage IV Colorectal Cancer: Cristina's Survivor Story

Patient Info: Cristina Patrick, Female | Stage IV

Metastatic Site: ovary

Cristina reported no evidence of disease since June 2021 after surgery and 6 months of chemotherapy for metastatic colon cancer.

Fight Colorectal Cancer
OutcomeCancer-Free / NED
A patient, who was diagnosed with Stage IV Lung AdenocarcinomaLung Cancer

Stage IV enteric-type lung adenocarcinoma with EGFR mutations and MSI-high disease

Patient Info: Anonymized, male, 60s | Stage IV

Biomarkers: EGFR exon 19 deletion; acquired EGFR T790M; MSI-high; high tumor mutation burden; MLH1 mutation; pMMR; PD-L1-negative

Metastatic Site: lung, pleura

The cancer progressed through multiple targeted, chemotherapy, and immunotherapy regimens. He died about 30 months after the initial diagnosis.

PubMed Central
OutcomeIn Memory
Deborah, who was diagnosed with Stage IV Lung CancerLung Cancer

Stage IV Lung Cancer: Deborah's Patient Story

Patient Info: Deborah Persinger, Female, 70+ | Stage IV

Metastatic Site: Brain

As of January 2024, Deborah was living actively 13 years after lung cancer diagnosis, with recurrent brain metastases managed through repeated Gamma Knife radiosurgery and ongoing MRI surveillance.

Cleveland Clinic
OutcomeLiving With Cancer
Jason, who was diagnosed with Stage IV Colorectal CancerColorectal Cancer

Stage IV Colorectal Cancer: Jason's Patient Story

Patient Info: Jason Reese, Male, 40s | Stage IV

Metastatic Site: Liver

As of January 2024, Jason still had active Stage IV rectal cancer, but extensive liver metastases had decreased from innumerable lesions to very few visible on scans, and treatment planning continued.

The Patient Story
OutcomeResponding Well
A patient, who was diagnosed with Stage IV Lung AdenocarcinomaLung Cancer

Rare lung cancer first discovered as a mass in the skull

Patient Info: Anonymized, Male | Stage IV

Biomarkers: KRAS ; CK7-positive; CDX2-positive; pathology favoured pulmonary enteric adenocarcinoma

Metastatic Site: skull base / sphenoid sinus; right posterior acetabulum

He received palliative radiation and prolonged systemic therapy, completing 35 cycles including 31 maintenance cycles of pemetrexed and pembrolizumab.

PubMed Central
OutcomeNot reported
Jim, who was diagnosed with Stage IV Colorectal CancerColorectal Cancer

Stage IV Colorectal Cancer: Jim's Patient Story

Patient Info: Jim Bromwich, Male, Under 40 | Stage IV

Metastatic Site: Lung

As of January 2024, he had completed focused radiation to an isolated lung nodule and was awaiting follow-up scans; another tiny lung nodule was being monitored but was not PET-avid.

The Patient Story
OutcomeCare Ongoing
Tiffany, who was diagnosed with Stage IV Lung CancerLung Cancer

Stage IV Lung Cancer: Tiffany's Patient Story

Patient Info: Tiffany, Female, Under 40 | Stage IV

Metastatic Site: Pelvis; right femur; cervical spine

As of January 2024, Tiffany’s story described rapid diagnosis of Stage IV lung cancer and evaluation at MD Anderson, with treatment planning underway but specific treatment details not stated.

The Patient Story
OutcomeCare Ongoing
A patient, who was diagnosed with Stage IV Invasive Lobular CarcinomaBreast Cancer

Metastatic invasive lobular breast carcinoma to pancreas: biliary stent and paclitaxel

Patient Info: Anonymized, Female, 40s | Stage IV

Biomarkers: Primary breast tumor was triple-negative. Pancreatic metastasis was ER-positive/GATA-positive

Metastatic Site: pancreas; coelio-mesenteric lymph nodes

After 21 years of remission, she developed pancreatic and coelio-mesenteric nodal metastases from invasive lobular breast carcinoma; palliative paclitaxel was stopped after 2 courses because her condition deteriorated, and she was lost to follow-up.

PubMed Central
OutcomeSetback / Progression
A patient, who was diagnosed with Stage IV Invasive Ductal CarcinomaBreast Cancer

Metastatic HER2-Positive Breast Cancer With Treatment-Related Telangiectasias

Patient Info: Anonymized, female, 60s | Stage IV

Biomarkers: HER2-positive; initially ER-negative and PR-negative; metastatic disease weakly ER-positive and PR-negative; germline testing negative

Metastatic Site: left supraclavicular, mediastinal, axillary and…

Living with HER2-positive breast cancer for 9+ years since her 2014 diagnosis, including metastatic disease since 2017. She remained on reduced-dose tucatinib in 2023 while treatment-related telangiectasias improved after dose reduction and electrocautery.

PubMed Central
OutcomeLiving With Cancer
Agnes, who was diagnosed with Stage IV Colorectal CancerColorectal Cancer

Stage IV Colorectal Cancer: Agnes's Patient Story

Patient Info: Agnes, 50s | Stage IV

She is living with Stage IV colorectal cancer and remains on palliative chemotherapy while waiting to learn whether surgery could become an option.

Our Cancer Stories
OutcomeCare Ongoing
A patient, who was diagnosed with Stage IV Colorectal AdenocarcinomaColorectal Cancer

Rectal signet ring cell cancer with an unusual metastasis into a lipoma

Patient Info: Anonymized, male, 40s | Stage IV

Metastatic Site: subcutaneous abdominal wall lipoma, peritoneum

Peritoneal carcinomatosis developed during adjuvant FOLFOX. Second-line chemotherapy was proposed, and he died 12 months later.

PubMed Central
OutcomeIn Memory
Anna, who was diagnosed with Stage IV Colorectal CancerColorectal Cancer

Anna

Patient Info: Anna | Stage IV

Metastatic Site: liver

At the time of the story, Anna was living with Stage IV colorectal cancer and was 2 weeks into a planned 6-month treatment course.

Our Cancer Stories
OutcomeCare Ongoing
MC
Colorectal Cancer

Metastatic colorectal carcinoma associated with hemophagocytic lymphohistiocytosis

Patient Info: Anonymized, Male, 50s | Stage IV

Metastatic Site: liver, lymph nodes

He had widespread metastatic carcinoma with severe liver involvement and malignancy-associated hemophagocytic lymphohistiocytosis. Rapid multiorgan failure led him to choose comfort care and hospice.

PubMed Central
OutcomeLiving With Cancer
A patient, who was diagnosed with Stage IV Gastric AdenocarcinomaGastric Cancer

Metastatic gastric cancer with an ATM mutation responding to olaparib

Patient Info: Anonymized, male, 60s | Stage IV

Biomarkers: Pathogenic germline ATM mutation, HER2-negative, PD-L1 15%

Metastatic Site: peritoneum

He had a deep response lasting about 18 months, but imaging in December 2023 again showed peritoneal carcinomatosis.

PubMed Central
OutcomeSetback / Progression
A patient, who was diagnosed with Stage IV Lung AdenocarcinomaLung Cancer

Stage IV EGFR-Mutant Lung Adenocarcinoma Responding to Osimertinib

Patient Info: Anonymized, female, 70+ | Stage IV

Biomarkers: EGFR L833V/H835L mutations; PD-L1 50%; CDK4 amplification; MDM2 amplification

Metastatic Site: contralateral lung, brain

After 3 months of osimertinib, the right upper lobe lesion had decreased and right hilar lymphadenopathy had resolved. The brain lesion remained stable, and subsequent imaging continued to show improvement in the lung lesion.

PubMed Central
OutcomeResponding Well
A patient, who was diagnosed with Stage IV Invasive Ductal CarcinomaBreast Cancer

BRCA2-Positive Breast Cancer in a Woman With Down Syndrome

Patient Info: Anonymized, female, Under 40 | Stage IV

Biomarkers: ER-positive, PR-negative, HER2-negative, germline BRCA2 pathogenic variant

Metastatic Site: lungs, bones

The cancer later progressed with lung and bone metastases and extensive cancer spread through lymphatic vessels in both lungs. She died 59 months after breast surgery.

PubMed Central
OutcomeIn Memory