Stage IV ALK Lung Adenocarcinoma: Niko's Patient Story

Patient Info: Niko, Female | Stage IV

Biomarkers: ALK mutation/rearrangement

Metastatic Site: Lymph nodes; Brain

As of May 2024, Niko’s Stage IV ALK-positive lung adenocarcinoma was controlled on ALK-targeted therapy, with no brain lesion seen on follow-up MRI/PET-CT and active disease described as dormant/stable.

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Stage IV Colorectal Cancer: Kyle's Patient Story

Patient Info: Kyle, Male, 40s | Stage IV

Metastatic Site: Liver

As of May 2024, Kyle was actively receiving chemotherapy for Stage IV sigmoid colon cancer with liver metastasis and was awaiting reassessment for possible surgery after 5 planned chemotherapy cycles.

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Rectal cancer with an isolated vaginal metastasis treated with repeat surgery

Patient Info: Anonymized, female, 70+ | Stage IV

Metastatic Site: vagina

After resection of an isolated vaginal metastasis, she was receiving ongoing adjuvant chemotherapy with good tolerance.

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Stage IV small cell lung cancer with metastases involving bone and both eye muscles

Patient Info: Anonymized, male, 40s | Stage IV

Metastatic Site: bone; bilateral extraocular muscles (orbits)

He died 5 months after presenting with bilateral orbital involvement while receiving palliative treatment for Stage IV small cell lung cancer.

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MSI-High Metastatic Hormone-Receptor-Positive Breast Cancer Responding to Pembrolizumab

Patient Info: Anonymized, female, 40s | Stage IV

Biomarkers: ER-positive; PR-positive; HER2-negative; MSI-high; BRCA mutation-negative

Metastatic Site: bone, para-aortic lymph nodes, brain

Pembrolizumab produced marked improvement in metastatic bone and nodal disease. After 1 year it was stopped because of appetite loss; 8 months later she was symptom-free and back at work on endocrine therapy, although asymptomatic brain metastases were documented.

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Stage 4 lobular breast cancer: bone therapy switch to denosumab

Patient Info: Anonymized, Female, 40s | Stage IV

Biomarkers: Not reported for breast cancer; CRP 21 mg/dL and ESR 27 mm/hr were elevated during orbital inflammation workup

Metastatic Site: bone

As of April 2024, zoledronate-associated ocular inflammation resolved within 2.5 weeks, vision returned to 20/20 after about 3 weeks, and bone-support treatment was changed to denosumab; breast-cancer response was not reported.

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Stage IV lung adenocarcinoma complicated by visceral leishmaniasis during chemotherapy

Patient Info: Anonymized, male, 50s | Stage IV

Biomarkers: EGFR wild-type; ALK negative; ROS negative; PD-L1 negative

Imaging showed progression while maintenance pemetrexed was temporarily interrupted; pemetrexed was then restarted during treatment for visceral leishmaniasis.

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ALK-positive lung adenocarcinoma complicated by crizotinib-associated kidney and liver cysts

Patient Info: Anonymized, female, 70+ | Stage IV

Biomarkers: ALK fusion

Metastatic Site: bone

After switching from crizotinib to alectinib, the lung cancer and hilar lymph nodes remained stable at the latest follow-up described.

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Jeff

Patient Info: Jeff, Male | Stage IV

Biomarkers: EGFR exon 19 deletion

Metastatic Site: brain|bones|lymph nodes

The lung mass shrank, 5 brain lesions and the involved lymph node had no evidence of disease, and Jeff described his condition as stable while continuing osimertinib and bone-strengthening infusions.

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Invasive lobular breast cancer with isolated scalp metastasis: excision and endocrine therapy

Patient Info: Anonymized, Female, 50s | Stage IV

Biomarkers: Original breast tumor: ER-positive; PR-positive; scalp metastasis: CK7-positive; ER-positive; GCDFP-15 partially positive

Metastatic Site: scalp/skin

As of April 2024, she had no signs of recurrence in the breast or scalp and no distant metastasis after excision of the isolated scalp metastasis while continuing anastrozole.

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Stage IV Colorectal Cancer: Zykeisha's Survivor Story

Patient Info: Zykeisha Law, Female, Under 40 | Stage IV

Metastatic Site: Liver; lung

As of April 2024, Zykeisha was back in remission after Stage IV colorectal cancer, recurrence involving lung and liver, additional chemotherapy, and multiple major surgeries; her last treatment was in April 2021.

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Elsa Lankford

Patient Info: Anonymized, Female, 40s | Stage IV

Biomarkers: Biomarker testing completed; results not reported

She remained in treatment for Stage IV colon cancer and had entered immunotherapy trial NCT05572684; reported side effects included skin rashes and increased anxiety.

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Stage IV Breast Cancer: Catherine's Survivor Story

Patient Info: Catherine, Female, 40s | Stage IV

Metastatic Site: Brain/cerebellum region

As of April 2024, Catherine said she had been in remission for almost 3 years after a 2019 metastatic recurrence near the cerebellum, while continuing preventive treatment.

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Rare non-small cell lung cancer with TTF-1 and p40 coexpression and later bone recurrence

Patient Info: Anonymized, male, 70+ | Stage IV

Biomarkers: PD-L1 TPS 60%; ALK negative; ROS1 negative

Metastatic Site: lumbar vertebrae

The cancer recurred in the lumbar vertebrae about 4 months after surgery, and he died from cancer 9 months after the operation.

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BRAF V600E lung adenocarcinoma with a response lasting more than 5 years on dabrafenib and trametinib

Patient Info: Anonymized, female, Under 40 | Stage IV

Biomarkers: BRAF ; PD-L1 TPS 100%

Metastatic Site: pleura

More than 5 years after her initial presentation, dabrafenib plus trametinib remained effective with no trend toward tumor progression.

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SMARCA4-deficient undifferentiated lung cancer with pleural disease and later spinal metastasis

Patient Info: Anonymized, male, 40s | Stage IV

Biomarkers: BRCA1 p.S1796 variant; TP53 p.; tumor mutational burden 12.6

Metastatic Site: spine

After chemotherapy and one cycle of nivolumab, a new 4.5 cm spinal metastasis caused cord compression and required surgery; further outpatient treatment was planned.

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Stage IV BRAF-mutated lung adenocarcinoma responding to second-line chemo-immunotherapy

Patient Info: Anonymized, female, Under 40 | Stage IV

Biomarkers: BRAF exon 15 p.T599dup; PD-L1 5%

Metastatic Site: pleura, pericardium

After progression on BRAF/MEK-targeted therapy, second-line chemo-immunotherapy produced a partial response that was still ongoing after about 1 year of second-line treatment.

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Ovarian Cancer Spreads to the Breast During Platinum-Resistant Recurrence

Patient Info: Anonymized, female, 50s | Stage IV

Biomarkers: BRCA1/2-negative; HRD-positive; PD-L1-positive; folate receptor alpha-positive

Metastatic Site: right breast, right axillary lymph nodes, cervical…

She remained alive with stable disease about 2 years after the breast metastasis was diagnosed while receiving seventh-line mirvetuximab-soravtansine.

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ALK-positive lung cancer treated with alectinib throughout pregnancy

Patient Info: Anonymized, Female | Stage IV

Biomarkers: ALK rearrangement / fusion-positive

Metastatic Site: pleura; liver; bone; brain

Alectinib produced a complete radiologic response and maintained intracranial control through pregnancy. She delivered a healthy infant at 37 weeks, with normal development at 26 months.

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Metastatic Breast Cancer With Recurrent Severe Hypocalcemia During Treatment - Case 1

Patient Info: Anonymized, female, Under 40 | Stage IV

Biomarkers: ER-positive; PR-positive; HER2-negative

Metastatic Site: bone, liver, ovaries

She died about 9 years after her breast-cancer diagnosis after progression of liver metastases.

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HER2-Positive Metastatic Breast Cancer With Recurrent Severe Hypocalcemia - Case 2

Patient Info: Anonymized, female, 60s | Stage IV

Biomarkers: ER-positive; PR-positive; HER2-positive

Metastatic Site: bone, liver

She died about 7 years after her breast-cancer diagnosis after rapid deterioration from liver metastases.

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Stage IV EGFR Non-Small Cell Lung Cancer: Anne's Patient Story

Patient Info: Anne Laporte, Female | Stage IV

Biomarkers: EGFR-mutated; several additional mutations mentioned but not specified

Metastatic Site: Spine; liver; lymph nodes

As of March 2024, Anne was living with Stage IVB EGFR-mutated NSCLC on a clinical trial after progression on Tagrisso, with early signs of decreased tumor burden and major improvement in pain.

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Stage IV Ovarian Cancer: Susan's Patient Story

Patient Info: Susan Dunwoody, female | Stage IV

Susan lived for 7 years after her Stage IV ovarian cancer diagnosis and later died from the disease.

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EGFR L858R/S768I lung adenocarcinoma with more than 5 years of survival after targeted therapy

Patient Info: Anonymized, male, 60s | Stage IV

Biomarkers: EGFR L858R and S768I compound mutation

Metastatic Site: bone, brain

He died on August 15, 2022, about 5 years and 4 months after his April 2017 presentation; afatinib had provided more than 3 years of disease control before later bone and brain progression.

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