Stage IV Colorectal Adenocarcinoma: Nick's Patient Story

Patient Info: Nick Sprague, Male, 40s | Stage IV

Metastatic Site: distant lymph nodes in abdomen/near aorta and left…

As of July 2024, Nick was living with Stage IVA colon cancer and receiving Keytruda/pembrolizumab with fewer side effects than chemotherapy; no NED status had been reached.

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Triple-positive breast cancer: complete response to targeted therapy

Patient Info: Anonymized, Female, 40s | Stage IV

Biomarkers: Triple-positive breast cancer; SBDS variants present; no detected TP53 variant on MyeloSeq.

Metastatic Site: liver

Stage IV triple-positive breast cancer with liver metastasis achieved complete response after paclitaxel, trastuzumab, pertuzumab, and G-CSF support; complete response was maintained for 18 months after treatment initiation while on maintenance HER2-directed and endocrine therapy.

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Stage IV Breast Cancer: Samantha's Patient Story

Patient Info: Samantha, Female, Under 40 | Stage IV

Biomarkers: Hormone-positive breast cancer; specific receptor details not reported

Metastatic Site: bone: rib, spine, pelvis

As of July 2024, Samantha was living with Stage IV hormone-positive breast cancer with bone metastases. Current treatment was working in most areas, but a breast tumor continued to grow and was surgically removed; ongoing treatment and 3-month scans were reported.

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Stage IV PD-L1-negative lung adenocarcinoma: complete response with nivolumab and ipilimumab

Patient Info: Anonymized, Female, 50s | Stage IV

Biomarkers: PD-L1-negative; no targetable molecular alterations on DNA/RNA next-generation sequencing; TP53 alteration reported at 66%

Metastatic Site: left pleural effusion; right adrenal gland;…

As of February 2024, she remained on maintenance nivolumab and ipilimumab after 14 cycles, without significant toxicity and with persistent complete response of Stage IV PD-L1-negative lung adenocarcinoma.

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Stage 4 lung cancer: complete response to chemo-immunotherapy combo

Patient Info: Anonymized, Male, 40s | Stage IV

Metastatic Site: right hilar lymph nodes, mediastinal lymph nodes

Stage IVA lung squamous cell carcinoma achieved complete response at 12 months. Pembrolizumab was stopped after immune-related RS3PE and likely colitis; 8 months after glucocorticoid initiation, there was no relapse of lung cancer or RS3PE.

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Stage IV Colorectal Adenocarcinoma: Elizabeth's Survivor Story

Patient Info: Elizabeth Wachsberg, Female | Stage IV

Metastatic Site: liver

As of July 2024, Elizabeth was 5 years cancer-free after Stage IV colon cancer with liver metastases, chemotherapy, and surgery.

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HR-positive HER2-negative metastatic breast cancer: bone metastases managed with sequential endocrine therapy

Patient Info: Anonymized, Female, 50s | Stage IV

Biomarkers: ER 90%+, PR 80%+, HER2-. CA 15-3 was tracked during treatment.

Metastatic Site: skull base; spine; sternum; ribs; left iliac bone;…

Metastatic HR-positive, HER2-negative breast cancer remained under active management; after earlier progression, palbociclib plus fulvestrant and zoledronic acid produced stable/remission findings on PET/CT at 3 months and again 1 year later, with continued 3-month follow-up recommended.

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Stage IV EGFR Non-Small Cell Lung Cancer: Leah's Patient Story

Patient Info: Leah Phillips, Female, 40s | Stage IV

Biomarkers: EGFR exon 19 deletion

Metastatic Site: bone (spine, pelvis); malignant right pleural…

As of July 2024, Leah remained on daily Tagrisso with stable Stage IV EGFR-mutated lung cancer, no reported progression, healing/sclerotic bone metastases, and durable response for more than 4 years.

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Stage 4 luminal A breast cancer: tumor regression on hormone therapy

Patient Info: Anonymized, Female, 40s | Stage IV

Biomarkers: ER-positive; PR-positive; HER2-negative

Metastatic Site: skin, soft tissue, lungs

Metastatic Luminal A breast cancer involving skin/soft tissue and lungs showed regressing tumors and stable lung metastasis after 3 months of anti-hormone therapy plus capecitabine; longer-term control was not reported.

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Stage IV EGFR-mutated lung cancer with acquired resistance to osimertinib

Patient Info: Anonymized, Female, 70+ | Stage IV

Biomarkers: EGFR L858R; acquired EGFR T790M; acquired EGFR L718Q

Metastatic Site: pleura, bone

After temporary disease control with sequential EGFR-targeted therapies, the right lung lesion enlarged again in June 2021; she was alive at the latest follow-up.

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Stage IV EGFR-mutated lung cancer treated after osimertinib resistance

Patient Info: Anonymized, Female, 60s | Stage IV

Biomarkers: EGFR L858R, TP53 mutation; acquired EGFR T790M; acquired EGFR L718Q

Metastatic Site: lungs, bone

Dacomitinib produced brief stable disease, but the lung cancer progressed again by September 2021; she was alive at the latest follow-up.

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Near-complete response to osimertinib in Stage IV lung adenocarcinoma with rare EGFR mutations

Patient Info: Anonymized, Male, 70+ | Stage IV

Biomarkers: EGFR S768I mutation, PD-L1 TPS 2%

Metastatic Site: pleura, bone, lymph nodes

After progression on vinorelbine and carboplatin, osimertinib produced a metabolic complete response by December 2023 and a near-complete radiologic response in March 2024. He remained on osimertinib with good tolerance and stable clinical condition.

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Metastatic lung cancer causing severe vena cava obstruction

Patient Info: Anonymized, Male, 70+ | Stage IV

Biomarkers: BRCA2 functional variant

Metastatic Site: bilateral adrenal glands, bone, pleura, lungs,…

Progressive metastatic lung cancer caused rapidly enlarging adrenal disease, worsening bone, pleural, pulmonary and nodal metastases, and malignant inferior vena cava obstruction. Endovascular iliocaval reconstruction restored venous flow without immediate complications.

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Stage IV lung squamous cell cancer complicated by adrenal insufficiency during immunotherapy

Patient Info: Anonymized, male, 50s | Stage IV

Mediastinal and hilar lymph nodes improved on treatment. Immunotherapy remained paused because of adrenal insufficiency, and updated follow-up found no recurrence or additional metastasis.

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Stage IV lung squamous cell cancer with bone metastasis and immunotherapy-related adrenal insufficiency

Patient Info: Anonymized, male, 70+ | Stage IV

Metastatic Site: rib/bone

After earlier progression with rib/bone destruction, the latest chest CT showed lung lesions similar to prior imaging. Tislelizumab remained paused because of adrenal insufficiency.

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A broken chemotherapy port catheter in a man with recurrent gastric cancer

Patient Info: Anonymized, male, 60s | Stage IV

Metastatic Site: peritoneum

The gastric cancer progressed after recurrence, and he died two months after surgery to remove a broken chemotherapy-port catheter.

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Stage IV gastric cancer complicated by a fractured gastric outlet stent

Patient Info: Anonymized, Male, 60s | Stage IV

Metastatic Site: peritoneum

He died while receiving palliative care 10 months after emergency surgery for a fractured-stent complication.

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Stage IV Non-Small Cell Lung Cancer: Lenny's Survivor Story

Patient Info: Lenny, Male, 50s | Stage IV

Biomarkers: PD-L1 expression positive

Metastatic Site: right femur; brain/cerebellum

As of July 2024, Lenny described himself as NED/no evidence of disease after surgery, CyberKnife radiation, chemotherapy, and Keytruda-based immunotherapy.

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Ovarian cancer lung metastasis followed by a benign staple-line granuloma

Patient Info: Anonymized, Female, 40s | Stage IV

Metastatic Site: lung

More than 10 years after her original ovarian-cancer surgery, a mass near the prior lung-metastasis staple line was surgically removed and proved to be a benign epithelial granuloma rather than recurrent cancer.

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RET-rearranged metastatic lung cancer responding to selpercatinib after pralsetinib

Patient Info: Anonymized, female, 50s | Stage IV

Biomarkers: KIF5B-RET fusion; PD-L1 negative

Metastatic Site: brain

More than 5 years after her 2018 diagnosis, selpercatinib was ongoing after 8 months with continued brain response and stable lung disease.

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RET-fusion lung adenocarcinoma responding to pralsetinib and bevacizumab

Patient Info: Anonymized, Male, 50s | Stage IV

Biomarkers: KIF13A-RET fusion

Metastatic Site: pleura

He had 27 months of disease-free survival on pralsetinib before pleural and nodal recurrence. After bevacizumab was added, imaging showed reduction of the pleural lesion and mediastinal nodes and circulating tumor DNA became undetectable in December 2023.

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Five-year survival with extensive-stage small cell lung cancer on atezolizumab

Patient Info: Anonymized, Male, 50s | Stage IV

Metastatic Site: bilateral lungs, cervical lymph nodes

Five years after diagnosis with extensive-stage small cell lung cancer, he was alive and well on maintenance atezolizumab with no further documented progression after the 2020–2021 rechallenge, reaching 60 months overall survival and about 44 months progression-free survival.

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Colon cancer that later spread to the testis and liver

Patient Info: Anonymized, male, 60s | Stage IV

Metastatic Site: right testis, liver

Liver metastasis was found 6 months after orchiectomy. Telephone follow-up confirmed that he survived for more than 18 months after the testicular surgery.

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Stage IV triple-negative breast cancer in remission: CBD and exercise for neuropathy

Patient Info: Anonymized, Female, 50s | Stage IV

Biomarkers: Triple-negative breast cancer. Blood and immune inflammation measures were tracked during neuropathy care.

Metastatic Site: liver

She was in remission for more than 5 years after Stage IV breast cancer with a solitary liver metastasis, while later managing chemotherapy-induced peripheral neuropathy with CBD and an exercise program that improved symptoms and function.

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