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A 64-year-old man sought care for upper abdominal pain. Endoscopy found a stomach tumor, and biopsy confirmed moderately differentiated gastric adenocarcinoma. Imaging also showed a 6 cm liver metastasis and several enlarged regional lymph nodes, making the disease Stage IV.
Tumor testing later showed HER2-negative, microsatellite-stable disease with very high PD-L1 expression. He received 4 cycles of S-1 plus oxaliplatin chemotherapy together with nivolumab. After treatment, the stomach tumor had become almost scar-like, while the liver metastasis and enlarged lymph nodes had also shrunk markedly.
With this strong response, he underwent distal gastrectomy with lymph-node removal and partial liver surgery. Examination of the surgical specimens found no viable cancer in the stomach, lymph nodes, or liver metastasis, representing a complete pathologic response.
He recovered from surgery without major complications and remained free of recurrence for 3 years and 3 months.
This is a lay summary of an account first published by PMC / PubMed Central. Read the original in full
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These are lay summaries of published cancer stories, for information only. No two cancers behave the same way, and nothing here predicts your own diagnosis or replaces advice from your oncology team. Read the full disclaimer