Stage III Large Cell Lung Cancer With Complete Response to Pembrolizumab-Based Treatment

Patient Info: Anonymized, male, 50s | Stage III

Biomarkers: PD-L1 TPS >60%; no actionable gene mutations identified

Imaging showed complete response of the recurrent hilar and mediastinal lymph nodes, and he remained progression-free through 24 cycles of treatment.

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Stage 3 squamous lung cancer: pathological complete response after immunotherapy and surgery

Patient Info: Anonymized, Male, 50s | Stage III

Pathologic complete response after DEB-BACE plus tislelizumab followed by thoracoscopic right middle/lower lobectomy and lymph-node dissection; postoperative chemo-immunotherapy continued and reexaminations were stable.

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Stage III HER2-Positive Breast Cancer Complicated by Systemic Sclerosis During Treatment

Patient Info: Anonymized, Female, 50s | Stage III

Biomarkers: HER2-positive

At 3-month follow-up after anticancer treatment was stopped, no breast-cancer recurrence or metastasis was detected.

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Stage III BRCA1 Ovarian Cancer: Carla's Survivor Story

Patient Info: Carla Peoples, female | Stage III

Biomarkers: BRCA1 mutation

She was cancer-free after surgery and 6 rounds of chemotherapy and continued olaparib maintenance with CA-125 blood testing every 3 weeks.

MD AndersonRead more →

Stage III Colorectal Cancer: Jose's Survivor Story

Patient Info: Jose Santos, Male, 40s | Stage III

As of December 2024, more than 2 years after surgery for Stage III colorectal cancer, Jose had no evidence of disease, had adapted well to his ileostomy, and no longer had ulcerative colitis symptoms.

City of HopeRead more →

Stage III Lung Cancer: Heidi's Survivor Story

Patient Info: Heidi, Female | Stage III

As of November 2024, Heidi was 6 years beyond her Stage IIIA lung cancer diagnosis and active in survivorship and advocacy through The White Ribbon Project; no explicit NED status was provided.

The Patient StoryRead more →

ROS1-Positive Stage III Pulmonary Sarcomatoid Carcinoma With Complete Pathologic Response

Patient Info: Anonymized, male, 60s | Stage III

Biomarkers: ROS1 rearrangement; TP53 mutation; PD-L1 TPS 0%

No recurrence was seen for more than 30 months after surgery following a complete pathologic response.

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Stage III Pulmonary Sarcomatoid Carcinoma With Major Response to Neoadjuvant Treatment

Patient Info: Anonymized, male, 50s | Stage III

Biomarkers: PIK3CA mutation; TP53 mutation; PD-L1 TPS 5%

No recurrence was detected for more than 29 months after surgery.

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Stage III Pulmonary Sarcomatoid Carcinoma With Major Response and No Recurrence

Patient Info: Anonymized, male, 50s | Stage III

Biomarkers: NRAS mutation; TP53 mutation; PD-L1 TPS 60%

No recurrence was detected for more than 27 months after surgery.

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Stage III Pulmonary Sarcomatoid Carcinoma Treated With Neoadjuvant Immunochemotherapy and Surgery

Patient Info: Anonymized, male, 60s | Stage III

Biomarkers: TP53 mutation; PD-L1 TPS 40%

No recurrence was detected for more than 30 months after surgery.

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Stage III Ovarian Cancer: Rachel's Patient Story

Patient Info: Rachel, female, Under 40 | Stage III

Biomarkers: CEA 125 reported as 1800

After surgery, Rachel learned she had Stage III ovarian cancer and was beginning to process the diagnosis with her family.

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Jazz: Stage III / borderline Stage IV colorectal cancer

Patient Info: Jazz, Male | Stage III

As of November 2024, Jazz was in active treatment for Stage III / borderline Stage IV colorectal cancer after colostomy surgery, chemotherapy, stomach tumor removal, and radiation, with surgery still planned for the remaining tumor.

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Stage III lung adenocarcinoma: neoadjuvant brigatinib, surgery, no evidence of disease

Patient Info: Anonymized, Female, 50s | Stage III

Biomarkers: Specific molecular alteration not stated in case 1 raw text; treated with brigatinib

No evidence of disease on PET-CT and brain MRI 27 months after surgery while receiving adjuvant brigatinib 90 mg daily.

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Stage III EML4-ALK lung adenocarcinoma: brigatinib, surgery, no evidence of disease

Patient Info: Anonymized, Female, 40s | Stage III

Biomarkers: EML4-ALK fusion rearrangement

No evidence of disease on PET-CT, with no brain metastases on MRI, after 32 months of adjuvant brigatinib following response and surgery.

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Stage III EGFR-mutated lung adenocarcinoma: osimertinib and surgery

Patient Info: Anonymized, Female, 70+ | Stage III

Biomarkers: EGFR L858R; EGFR L861Q

No evidence of disease on PET-CT or brain MRI after 42 months of follow-up following neoadjuvant osimertinib and surgery.

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Stage III EGFR exon 19-deleted lung adenocarcinoma: osimertinib and surgery

Patient Info: Anonymized, Female, 50s | Stage III

Biomarkers: EGFR exon 19 deletion

No sign of metastasis on PET-CT or brain MRI after 24 months of follow-up following neoadjuvant osimertinib, left upper-lobe resection, and adjuvant osimertinib.

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Stage III Colorectal Cancer: Jazz's Patient Story

Patient Info: Jazz Page, Male | Stage III

As of November 2024, Jazz was still in active treatment planning with radiation, oral chemotherapy pills, and final surgery expected; no post-treatment remission status was reported.

The Patient StoryRead more →

Stage 3C lung cancer: complete remission on immunotherapy and chemotherapy

Patient Info: Anonymized, Male, 40s | Stage III

Biomarkers: EGFR wild-type; ALK rearrangement not detected; PD-L1 <1%

Complete tumor remission with no recurrence more than 6 months after durvalumab, tremelimumab, carboplatin, and nab-paclitaxel for Stage IIIC driver-negative NSCLC, despite severe immune, infectious, cardiac, renal, and fistula complications that later resolved or stabilized.

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Stage III Colorectal Cancer: Paul's Patient Story

Patient Info: Paul Klug, Male | Stage III

As of October 2024, Paul was on the final day of round 4 of 5 planned chemotherapy rounds, with chemoradiation and possible resection surgery still ahead.

The Patient StoryRead more →

Paul: Stage III Colorectal Cancer

Patient Info: Paul, Male | Stage III

As of October 2024, Paul was in active care for Stage III rectal cancer with CAPOX chemotherapy, planned radiation, and eventual surgery.

The Patient StoryRead more →

Stage III Lung Adenocarcinoma Treated With Complex Lung-Sparing Surgery and Adjuvant Therapy

Patient Info: Anonymized, male, Under 40 | Stage III

Biomarkers: PD-L1 high expression

Follow-up through 3 years after surgery showed no recurrence or metastasis, with stable lung function and unrestricted physical activity.

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Stage III Colorectal Cancer: Jessenia's Patient Story

Patient Info: Jessenia, Female, Under 40 | Stage III

As of September 2024, Jessenia had completed major treatment steps and was adapting to the physical and emotional effects of treatment, including a temporary colostomy; a clear remission/NED status was not stated.

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Stage III HER2-Positive Occult Breast Cancer With a Complete Response to Treatment

Patient Info: Anonymized, Female, 40s | Stage III

Biomarkers: HER2-positive

Surgery after neoadjuvant treatment found no residual tumor in the breast or 20 examined lymph nodes, indicating a complete pathologic response; HER2-targeted therapy continued afterward.

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Stage III Colorectal Cancer: Alicia's Patient Story

Patient Info: Alicia Blakey, Under 40 | Stage III

Alicia was undergoing FOLFOX chemotherapy for Stage III colon cancer through October 2024 after colon surgery in May.

Fight Colorectal CancerRead more →