Stage III HR-Positive Invasive Lobular Carcinoma: Courtney's Patient Story

Patient Info: Courtney, Female, Under 40 | Stage III

Biomarkers: ER-positive; PR-positive; HER2-negative

As of June 2025, Courtney was recovering from Stage III ER-positive, PR-positive, HER2-negative ILC treatment after double mastectomy, Taxotere/Cytoxan chemotherapy, and 25 rounds of radiation, with reconstructive surgery delayed by radiation skin injury.

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Stage III Colorectal Cancer: Paige's Patient Story

Patient Info: Paige Cipher, Female, Under 40 | Stage III

Paige had Stage III rectal cancer and was still in treatment. After 6 rounds of chemotherapy, the tumor had shrunk but was not gone; as of June 2025, she had just completed round 7, had 1 more round planned, and expected surgery in about 3 weeks.

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Stage III Colorectal Cancer: Jackson's Survivor Story

Patient Info: Jackson, Male, Under 40 | Stage III

Jackson completed surgery and chemotherapy for Stage III colon cancer. After his final infusion on January 28, 2025, Signatera was negative, chest and abdomen CTs were clear, tumor-marker bloodwork was negative, and he was declared in remission/no evidence of disease; a later CT in June 2025 was also clear.

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Stage III Lung Cancer: Alexis's Survivor Story

Patient Info: Alexis, Female, Under 40 | Stage III

Biomarkers: No lung tumor biomarker reported

Alexis had Stage III pulmonary neuroendocrine/carcinoid cancer treated with removal of the entire left lung and 4 months of adjuvant pill chemotherapy. Follow-up scans after chemotherapy were clear, and her doctor called the status no evidence of disease; she continues long-term surveillance.

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ALK-rearranged lung adenocarcinoma: sustained partial response on reduced-dose crizotinib after renal cysts

Patient Info: Anonymized, Male, 50s | Stage III

Biomarkers: ALK gene translocation positive in >15% of tumor cells by FISH

As of June 2025, the lung cancer remained in partial response without progression on reduced-dose crizotinib, while crizotinib-associated renal cysts had markedly regressed.

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Stage III Colorectal Cancer: James's Survivor Story

Patient Info: James, Male | Stage III

James had Stage IIIC / possible Stage IV rectal cancer with major lymph node involvement and an uncertain liver spot. After chemotherapy, radiation, multiple surgeries, permanent colostomy, and adjuvant chemotherapy, he later reported no evidence of disease.

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Stage III HR-Positive Invasive Lobular Carcinoma: Tanya's Patient Story

Patient Info: Tanya, Female, 40s | Stage III

Biomarkers: ER-positive; PR-positive; HER2-negative; grade 1

As of May 2025, Tanya was recovering from chest wall surgery, ALT flap repair, and a later skin graft after developing angiosarcoma in her radiated reconstructed breast years after Stage IIIA ILC treatment.

Lobular Breast Cancer AllianceRead more →

Stage IIIB ER/PR-positive breast cancer: emergency mastectomy for infected fungating tumor

Patient Info: Anonymized, Female, 70+ | Stage III

Biomarkers: ER >75%; PR >75%; HER2 0 / HER2-negative; grade 3 invasive ductal carcinoma

As of May 2025, management centered on anastrozole after emergency mastectomy, repeated debridements, wound care, and major postoperative complications; oncology follow-up had become inconsistent because of ongoing medical setbacks.

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Stage III HR-Positive Breast Cancer: Christine's Survivor Story

Patient Info: Christine, Female, Under 40 | Stage III

Biomarkers: ER-positive; PR-positive; HER2-positive

Three years after diagnosis, Christine described herself in the survivorship stage and focused on the physical and emotional effects that continued after active treatment.

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Lynch syndrome bifocal colon cancer: complete pathological remission after sintilimab

Patient Info: Anonymized, Male, 40s | Stage III

Biomarkers: Lynch-associated colon cancer with MSI-H and KRAS/NRAS/BRAF wild type; tumor markers were low or near normal.

As of April 2025, pathology after proximal colectomy showed tumor regression grade 0 with complete pathological remission, and follow-up found no recurrence or metastasis.

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Stage IIIA double ALK-fusion lung adenocarcinoma: major pathological response to neoadjuvant alectinib

Patient Info: Anonymized, Male, 50s | Stage III

Biomarkers: ALK-rearranged lung adenocarcinoma with both ELMOD3-ALK and EML4-ALK fusions. CEA/NSE/CA19-9 decreased after alectinib.

As of April 2025, he had continued alectinib for 4 years after surgery, with more than 48 months of disease-free survival, no recurrence, and no serious drug-related toxicity.

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Stage III colon cancer followed by a second gastro-oesophageal adenocarcinoma

Patient Info: Anonymized, Female | Stage III

Biomarkers: KRAS-mutated, NRAS-negative, BRAF-negative

After surgery and 4 cycles of CAPEOX, imaging initially showed no metastases. Later imaging showed new bilobar liver lesions, and a separate primary gastro-oesophageal adenocarcinoma was diagnosed about 1 year after the colon cancer.

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Stage III Colorectal Adenocarcinoma: Chloe's Survivor Story

Patient Info: Chloe, Female | Stage III

Biomarkers: Familial adenomatous polyposis

As of April 2025, Chloe was in remission after emergency surgery with a stoma and 4 rounds of IV/oral chemotherapy for Stage III FAP-associated colon adenocarcinoma.

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Stage III Lung Squamous Cell Carcinoma Diagnosed After Months of COPD-Like Symptoms

Patient Info: Anonymized, male, 40s | Stage III

He died 6 months after his lung-cancer diagnosis from pneumonia complicated by COPD that did not respond to targeted antibiotic treatment.

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Stage III Large-Cell Lung Carcinoma Found During Recurrent Pneumonia in a Woman With COPD

Patient Info: Anonymized, female, 50s | Stage III

She died 17 days after the lung-cancer diagnosis while being treated for recurrent pneumonia complicated by COPD.

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Left breast epithelioid MPNST with concurrent right breast cancer: no recurrence after surgery

Patient Info: Anonymized, Female, 70+ | Stage III

Biomarkers: Left MPNST markers included S100 and SOX10 positivity. Right breast cancer was ER/PR-positive, HER2-negative/1+

As of March 2025, 3 years after bilateral mastectomy, there was no recurrence of the left epithelioid MPNST or the concurrent right breast invasive ductal carcinoma.

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Bilateral inflammatory breast cancer treated with pembrolizumab and surgery

Patient Info: Anonymized, Female, 40s | Stage III

Biomarkers: Bilateral breast cancers had different biology: right side ER/PR-positive and HER2 FISH-negative; left side triple-negative/HER2 1+.

As of March 2025, she had no recurrence 6 months after bilateral mastectomy, bilateral axillary lymph node dissection, thoracoabdominal flap closure, and planned postmastectomy radiation for Stage IIIC bilateral inflammatory breast cancer.

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Stage 3 squamous cell lung cancer: complete remission on tislelizumab monotherapy

Patient Info: Anonymized, Male, 70+ | Stage III

Biomarkers: Squamous lung cancer markers: P40 positive, TTF-1/Napsin A negative, Ki-67 75%. PD-1/PD-L1 testing was not done.

As of April 2024, enhanced CT, tumor-marker decline, and clinical assessment supported complete remission by iRECIST after chemoimmunotherapy and tislelizumab monotherapy.

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Stage III Colorectal Cancer: Chloe's Survivor Story

Patient Info: Chloe, Female, Under 40 | Stage III

Biomarkers: Rare genetic disorder/gene reported; exact gene not stated

Chloe was diagnosed with Stage III colon cancer in February 2024 after emergency surgery. After surgery, stoma creation, and 3 months of chemotherapy, she was told she was in remission in June 2024 and remained on surveillance.

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Mark: Stage III Colorectal Cancer

Patient Info: Mark, Male, Under 40 | Stage III

Biomarkers: Lynch syndrome negative

As of March 2025, Mark was sharing his story after surgery and intensive chemotherapy for Stage IIIB colon cancer and had been declared to have no evidence of disease in 2021.

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Stage III Colorectal Cancer: Courtney's Survivor Story

Patient Info: Courtney Vigars, Female, Under 40 | Stage III

In her fifth year of remission at the time of the 2025 story after transanal surgery, radiation, and chemotherapy for Stage III rectal cancer; she had returned to an active working life.

Cleveland ClinicRead more →

Stage III Colorectal Cancer: Mark's Survivor Story

Patient Info: Mark, Male, Under 40 | Stage III

Biomarkers: Tumor genetic testing negative; Lynch syndrome not detected

Mark had Stage III right-sided colon cancer treated with surgery and chemotherapy. He has been considered no evidence of disease since finishing chemotherapy in spring 2021 and had passed the 4-year post-surgery milestone as of March 2025.

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Stage III Colorectal Cancer: Heather's Survivor Story

Patient Info: Heather Russell, Female, Under 40 | Stage III

In her fifth year of remission at the time of the 2025 story after treatment for Stage III rectal cancer; she had returned to family and working life, with some lasting treatment effects.

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Edie: Stage III Colorectal Cancer

Patient Info: Edie, Female, 50s | Stage III

As of March 2025, Edie had recovered after chemotherapy, radiation, lower anterior resection, temporary ileostomy, and reversal; lymph nodes were negative, margins were clean, and follow-up scans and colonoscopies had remained clear.

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