Stage 4 lung cancer: complete resection after splenectomy

Patient Info: Anonymized, Male, 60s | Stage IV

Biomarkers: TTF-1-positive; Synaptophysin-positive; CD56-positive

Metastatic Site: spleen

No evidence of recurrence 1 year after open splenectomy/partial diaphragm resection and later R0 resection of the primary lung tumor for Stage IVB lung cancer with splenic metastasis; systemic therapy was refused.

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Stage 4 small cell lung cancer: response to carboplatin, etoposide, and atezolizumab

Patient Info: Anonymized, Male, 50s | Stage IV

Biomarkers: CD56-positive; synaptophysin-positive

Metastatic Site: right hilar/mediastinal disease, left adrenal gland,…

Extensive-stage small-cell lung cancer presenting with chronic intestinal pseudo-obstruction improved after 3 cycles of carboplatin, etoposide, and atezolizumab, with PET response and symptomatic improvement; longer-term durability was not reported.

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Small cell lung cancer presenting with SVC stenosis and pulmonary emboli: stenting and anticoagulation before oncology follow-up

Patient Info: Anonymized, Female, 50s

Biomarkers: Synaptophysin-positive; chromogranin-positive; CD56-positive; TTF1-positive; BCL-2-positive

As of June 2024, symptoms from SVC stenosis had nearly resolved after SVC stenting, venoplasty, and anticoagulation, and outpatient oncology follow-up for newly diagnosed small cell lung cancer was planned.

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Stage I Lung Cancer: Lauren's Patient Story

Patient Info: Lauren Koy, Female, Under 40 | Stage I

Biomarkers: CD56-positive neuroendocrine tumor; no gene mutations reported

As of January 2024, Lauren’s diagnosis had been established and bronchoscopy had reopened the blocked right-lung airway; later definitive treatment or long-term status was not described in this record.

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Stage I Lung Cancer: Lauren's Survivor Story

Patient Info: Lauren, Female, Under 40 | Stage I

Biomarkers: CD56-positive; neuroendocrine tumor

As of August 2023, Lauren reported no signs of more cancer after bronchoscopy and surgery removing the right lower and middle lung lobes, with surveillance extended to yearly CT scans.

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Small Cell Lung Cancer Presenting With a Nasal Cavity Metastasis

Patient Info: Anonymized, male, 50s

Biomarkers: CD56 positive, chromogranin positive, synaptophysin positive

After 12 months in remission, the nasal cavity disease recurred aggressively. He declined further palliative chemotherapy and died 2 months later, 14 months after diagnosis.

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Stage III gastric neuroendocrine carcinoma with signet-ring cells remains recurrence-free 6 years after surgery

Patient Info: Anonymized, Male, 60s | Stage III

Biomarkers: synaptophysin-positive; CD56-positive; Ki-67 23.1%

At 72 months, or 6 years, after surgery, he remained alive without recurrence.

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Large locally invasive gastric adenocarcinoma with a gastrocutaneous fistula treated by multivisceral surgery

Patient Info: Anonymized, Female, 70+

Biomarkers: chromogranin-positive; CD56-positive

She developed severe respiratory distress and pneumonia on postoperative day 10 and died 20 days after surgery despite antibiotics and intensive care.

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