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A 67-year-old man sought care for a heavy feeling in his stomach. Repeated endoscopy and biopsy eventually identified poorly differentiated gastric adenocarcinoma with neuroendocrine differentiation. Further evaluation showed a main gastric tumor and multiple smaller intramural lesions spread through much of the stomach.
He underwent total gastrectomy and splenectomy with D2 lymph-node dissection. Pathology showed large-cell neuroendocrine carcinoma with signet-ring cell carcinoma in the superficial component and multiple intramural metastases within the stomach. One regional lymph node contained metastasis. The tumor was synaptophysin-positive and CD56-positive, with a Ki-67 index of 23.1%. The final pathological stage was IIIA, normalized here to Stage III.
The resection margins were negative. After recovery, he received postoperative tegafur-uracil chemotherapy. At 72 months, or 6 years, after surgery, he remained alive without recurrence.
This is a lay summary of an account first published by PMC / PubMed Central. Read the original in full
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These are lay summaries of published cancer stories, for information only. No two cancers behave the same way, and nothing here predicts your own diagnosis or replaces advice from your oncology team. Read the full disclaimer