Adrenal metastasis from gastric cancer causing adrenal insufficiency

Patient Info: Anonymized, male, 60s | Stage IV

Biomarkers: HER2-negative, PD-L1-negative

Metastatic Site: right adrenal gland

More than 17 months after the metastatic relapse, he was clinically well with no radiological or biochemical signs of active cancer apart from the residual right adrenal lesion.

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Immunotherapy and surgery for lung adenocarcinoma with two brain metastases

Patient Info: Anonymized, Female, 50s

Biomarkers: PD-L1 100%; no actionable mutations on next-generation sequencing.

After brain surgery, radiation, 11 cycles of pembrolizumab, and lung surgery, she was off treatment and under observation in remission.

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Stage III KRAS Non-Small Cell Lung Cancer: Terri's Survivor Story

Patient Info: Terri Conneran, Female | Stage III

Biomarkers: KRAS-mutated; PD-L1 level reviewed/tested

As of March 2021, Terri had Stage IIIA KRAS-mutated NSCLC with 3 local recurrences treated over time and had again reached no evidence of disease while continuing close surveillance and advocacy through KRAS Kickers.

The Patient StoryRead more →

Local Breast Cancer Recurrence Was Found During BioZorb Surveillance

Patient Info: Anonymized, Female, 70+

Biomarkers: Initial right breast tumor: ER-positive, PR-positive, HER2-equivocal. Recurrent right breast tumor: ER-positive, HER2-negative.

Two sites of right-breast recurrence were confirmed three years after lumpectomy, leading to right mastectomy.

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Stage I Lung Cancer: Deborah's Patient Story

Patient Info: Deborah Schroeder, Female | Stage I

As of December 2020, Deborah had completed 3 separate 4-day SBRT courses for Stage I lung cancers and remained under monitoring for about 10 tiny lung nodules that had been stable for years.

MD AndersonRead more →

Breast Cancer Recurrence Treated With Radiation Despite a Chronic Skin Condition

Patient Info: Anonymized, Female, 50s

Biomarkers: ER-positive; PR-positive; HER2-negative

After treatment of a chest-wall recurrence and a radiographically suspicious ischial lesion, she completed chest-wall radiation, her skin healed within 5 weeks, and she remained under surgical, radiation-oncology, and dermatology review.

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Nivolumab-Related Myocarditis and Heart Block in Metastatic Lung Cancer

Patient Info: Anonymized, Male, 70+ | Stage IV

Metastatic Site: left adrenal gland

He stabilized after high-dose steroids and pacemaker implantation after nivolumab was permanently stopped.

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Durable brain and leptomeningeal response to pembrolizumab in Stage IV lung cancer

Patient Info: Anonymized, Female, 70+ | Stage IV

Biomarkers: PD-L1 high positive; EGFR negative; BRAF negative; KRAS negative; ROS1 negative; ALK negative

Metastatic Site: right adrenal gland, left sixth rib, brain,…

After 29 pembrolizumab cycles over 20 months, imaging showed no leptomeningeal disease, resolution of 3 brain lesions and marked reduction of the dominant frontal lesion; she remained neurologically intact and radiographically stable.

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Stage IV Lung Cancer: Cynthia's Patient Story

Patient Info: Cynthia Hess, Female | Stage IV

Metastatic Site: Spine

As of October 2018, Cynthia’s spine metastasis had stopped growing after one stereotactic spinal radiosurgery treatment, her neck pain had subsided and future MRI scans were planned for monitoring.

Cleveland ClinicRead more →

HER2-Positive Recurrent Breast Cancer Treated With Multiple Targeted and Local Therapies

Patient Info: Anonymized, female, 50s | Stage IV

Biomarkers: 2008 recurrence: ER 80%, HER2 FISH amplified. 2011 recurrence: ER 80%

Metastatic Site: liver, skin

After 25 cycles of eribulin, treatment was still ongoing; nodal disease remained stable, while later imaging also noted new metabolic activity in the upper lung.

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Five Years Without Recurrence After Surgery and Gamma Knife for a Cerebellar Metastasis From EGJ Cancer

Patient Info: Anonymized, female, 70+ | Stage IV

Biomarkers: CK7 negative, CK20 positive

Metastatic Site: cerebellum

Five years after removal of the cerebellar metastasis and Gamma Knife radiosurgery, she was asymptomatic with no evidence of recurrence.

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Oligometastatic Lung Cancer With Brain Spread, Surgery and Later Recurrence

Patient Info: Anonymized, male, 60s | Stage IV

Metastatic Site: brain

After 15 months off treatment he developed mediastinal nodal and distant metastases and was alive with disease on platinum-based chemotherapy 25 months after surgery.

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Stage IV ERBB2-Mutated Lung Adenocarcinoma With Brain Metastases and Multiple Targeted Therapies

Patient Info: Anonymized, female, Under 40 | Stage IV

Biomarkers: ERBB2 exon 20 insertion, exact sequence not specified. ERBB2 copy-number gain was identified during progression on afatinib.

Metastatic Site: brain, adrenal gland, liver

The final documented afatinib plus bevacizumab rechallenge produced a mixed response followed by liver progression after 3 months.

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Sigmoid colon cancer: complete response after repeated metastatic recurrences and multimodal therapy

Patient Info: Anonymized, Male, 60s | Stage IV

Biomarkers: KRAS/NRAS/BRAF status not reported; CEA elevation used for recurrence monitoring

Metastatic Site: left lung, mediastinal lymph nodes, left adrenal…

By 2011, all metastatic lesions had achieved complete response; nearly 1 year after the last adrenal irradiation, no recurrence had been detected.

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Stage IA lung cancer: no local recurrence 40 months after SBRT

Patient Info: Anonymized, Female, 70+ | Stage I

Biomarkers: Serum CEA elevated before SBRT; KL-6 normal; SP-D normal. Tumor genomic biomarkers not reported.

Alive without local recurrence 40 months after SBRT, after suspicious post-radiation consolidation was monitored and biopsy showed no cancer cells.

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