Stage IV Ovarian Cancer With Severe Recurrent Ascites

Patient Info: Anonymized, Female | Stage IV

Metastatic Site: peritoneum|liver

The cancer progressed with massive ascites, liver involvement, and respiratory failure. She died from multiorgan failure related to metastatic ovarian cancer.

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Splenectomy Reduced Transfusion Needs in Metastatic Lobular Breast Cancer

Patient Info: Anonymized, Female, 40s | Stage Metastatic/Advanced

Biomarkers: ER positive; PR positive; HER2 negative

Metastatic Site: skin|bone|bone marrow|spleen

She remained independent through her last oncology visit 18 months after splenectomy and died 1 month later.

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Stage II HER2-Positive Breast Cancer With Anti-Yo Paraneoplastic Cerebellar Degeneration

Patient Info: Anonymized, female, 50s | Stage II

Biomarkers: HER2 positive

Her severe anti-Yo paraneoplastic cerebellar syndrome did not meaningfully respond to IVIG or cancer treatment. She became wheelchair-dependent and ultimately required long-term care, with only moderate improvement in ataxia after rehabilitation.

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Lobular Breast Cancer Spreading to an Eye Muscle

Patient Info: Anonymized, Female, 40s | Stage Metastatic/Advanced

Biomarkers: Hormone receptor-positive; HER2-negative; E-cadherin-negative; CK7-positive

Metastatic Site: bones|left superior oblique eye muscle

The eye-muscle metastasis entered complete local remission, while bone disease was stable after 6 months of weekly paclitaxel and denosumab.

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Recurrent Ovarian Cancer With Dermatomyositis and Peritoneal Progression

Patient Info: Anonymized, Female, 50s

Her disease progressed during weekly paclitaxel, and she was considered unfit for further treatment.

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Ovarian Cancer With Pleural Spread and Recurrent Dermatomyositis

Patient Info: Anonymized, Female, 40s | Stage Metastatic/Advanced

Metastatic Site: pleura

She had symptomatic improvement after 2 cycles of carboplatin and liposomal doxorubicin for recurrent disease.

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Stage II metaplastic breast cancer in a 47-year-old man

Patient Info: Anonymized, Male, 40s | Stage II

Biomarkers: ER 1%; PR negative; HER2 negative; E-cadherin positive; p63 positive; genetic testing reported no abnormal mutations

Two years after surgery he was doing well, with only occasional pain at the mastectomy site and a negative recent mammogram of the left breast.

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Triple receptor-positive neuroendocrine breast cancer in a 32-year-old woman

Patient Info: Anonymized, Female, Under 40 | Stage III

Biomarkers: ER positive; PR positive; HER2 positive; neuron-specific enolase positive; synaptophysin positive

She was stable on follow-up and was receiving adjuvant chest-wall radiation plus systemic chemotherapy and trastuzumab-based therapy.

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Metastatic Breast Cancer With Liver Progression Treated Through Multiple Chemotherapy Lines

Patient Info: Anonymized, female, 40s | Stage IV

Biomarkers: Initial tumor: ER 90%, HER2 3+, Ki67 15%. Liver metastasis: ER 30%

Metastatic Site: pleura, liver

After several periods of response and later liver progression, she remained on active treatment with pegylated liposomal doxorubicin.

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Recurrent Breast Cancer With Liver Metastases Treated Through Multiple Chemotherapy Lines

Patient Info: Anonymized, female, 60s | Stage IV

Biomarkers: Initial tumor: ER positive, HER2 0. Liver metastasis: ER 100%

Metastatic Site: liver

After liver progression following 18 cycles of eribulin, she started weekly carboplatin and remained in active treatment.

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Metastatic Breast Cancer With Brain, Bone, Lung and Liver Disease Responding During Eribulin Treatment

Patient Info: Anonymized, female, 40s | Stage IV

Biomarkers: Initial tumor: ER 90%, HER2 negative, Ki67 10%. Lung metastasis: ER 90%

Metastatic Site: lung, bone, brain, liver

Eribulin remained ongoing with reduced brain lesions, stable bone disease and continued shrinkage of liver metastases after prior systemic progression.

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Stage III HER2-Positive Invasive Ductal Carcinoma: Dorothy's Survivor Story

Patient Info: Dorothy Paterson, Female, 40s | Stage III

Biomarkers: HER2-positive

As of November 2016, Dorothy had remained cancer-free since completing treatment for Stage III HER2-positive invasive ductal carcinoma in April 1999.

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Stage III Inflammatory Breast Cancer Diagnosed After Severe Breast Pain and Swelling Following Mammography

Patient Info: Anonymized, female, 60s | Stage IV

Biomarkers: ER negative, PR negative, HER2 highly positive

After later metastatic disease was found, she chose no further active treatment and died of progressive disease in 2012.

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Stage III Ovarian Cancer Treated Over Years Before a Separate Oral Cancer

Patient Info: Anonymized, female, 40s | Stage III

Biomarkers: BRCA1 mutation

After prolonged treatment for recurrent ovarian cancer, follow-up visits documented her as free from ovarian disease.

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Breast invasive ductal carcinoma with coexisting inflammatory myofibroblastic tumor: disease-free after mastectomy, TAC, and tamoxifen

Patient Info: Anonymized, Female, Under 40

Biomarkers: Breast cancer: ER/PR-positive with HER2 2+ and p53-positive. Separate inflammatory myofibroblastic tumor had ALK/vimentin/actin/S-100 markers.

As of August 2013, she remained disease-free 2 years after modified radical mastectomy, 6 courses of TAC chemotherapy, and tamoxifen.

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Recurrent Ovarian Cancer With Tumor Lysis Syndrome After Chemotherapy

Patient Info: Anonymized, female, 60s | Stage IV

Metastatic Site: lungs

After 9 years of stable disease, the ovarian cancer progressed extensively and the first cycle of renewed chemotherapy was complicated by severe tumor lysis syndrome and multiorgan illness.

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BRCA1-associated right invasive ductal carcinoma followed by left acinic cell carcinoma of the breast

Patient Info: Anonymized, Female, 40s

Biomarkers: Constitutional BRCA1 mutation. Right breast cancer was ER/PR positive, HER2 negative; later left tumor was triple-negative with TP53 change.

After treatment for right invasive ductal carcinoma and later contralateral acinic cell carcinoma, she was alive and well 19 months after the acinic cell carcinoma surgery, with no evidence of disease while continuing hormonal therapy.

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Metastatic lobular breast cancer to gynecologic sites: disease-free after surgery and chemotherapy

Patient Info: Anonymized, Female, 50s | Stage IV

Biomarkers: ER-positive; PR-negative; HER2/C-Erb-B2-negative

Metastatic Site: vagina, uterus, ovaries

After treatment of vaginal, uterine, and ovarian metastases from lobular breast cancer, she was free from disease 12 months after completion surgery.

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Hormone-positive breast cancer with axillary recurrence responding to hyperthermia, radiation, and chemotherapy

Patient Info: Anonymized, Female, 60s

Biomarkers: ER-positive; PR-positive; HER2-negative

The left axillary recurrence enlarged during weekly paclitaxel and radiotherapy, then became nearly flat and was assessed as a complete response 8 weeks after adding hyperthermia.

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Recurrent Stage III Ovarian Cancer Complicated by Severe Kidney Injury

Patient Info: Anonymized, female, 70+ | Stage III

After further intra-abdominal cancer progression and severe kidney injury, she developed seizures, encephalopathy, and limb ischemia and died 1 week after hospitalization in May 2011.

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Recurrent Ovarian Cancer With Treatment-Related Kidney Failure and Dialysis

Patient Info: Anonymized, female, Under 40

The ovarian cancer later progressed with enlarging pelvic masses, rectal obstruction, and intestinal perforation, and she died in February 2011.

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Recurrent Ovarian Cancer With Severe Kidney Injury During Long-Term Treatment

Patient Info: Anonymized, female, 60s

Despite severe chronic kidney disease, later chemotherapy produced some regression of the progressing ovarian cancer with each sequential regimen.

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Stage III Ovarian Cancer in a BRCA1 Carrier Treated With Long-Term Maintenance Therapy

Patient Info: Anonymized, 50s | Stage III

Biomarkers: BRCA1 mutation

After long-term maintenance therapy, she had no evidence of ovarian cancer at the latest follow-up.

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Recurrent Stage III Ovarian Cancer in a BRCA2 Carrier Treated Over Many Years

Patient Info: Anonymized, 40s | Stage III

Biomarkers: BRCA2 mutation

She later developed a separate aggressive oral squamous cell carcinoma and died in 2011 from acute airway obstruction during progression of that cancer.

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