Stage IV Lung Cancer treatment and follow-up story

Patient Info: Tina Powell, Female | Stage IV

As of January 2026, Tina was 3 years into Stage IV lung cancer, on a clinical trial at Memorial Sloan Kettering, and undergoing CT chest, CT pelvis, and brain MRI every 6 weeks.

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Stage IV Colorectal Cancer: Kina's Survivor Story

Patient Info: Kina, Female | Stage IV

Metastatic Site: Lungs; lymph node

As of January 2026, Kina described herself as technically having no cancer/no evidence of disease after lung resections, though confirmatory CT was still pending and she was still recovering from complications.

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Stage IV HER2-Positive Breast Cancer: Sonja's Patient Story

Patient Info: Sonja Rideout, Female | Stage IV

Biomarkers: HER2-positive; Tempus testing later indicated immunotherapy as an option

Metastatic Site: Lungs; liver; bone: tailbone; thoracic lymph nodes

As of January 2026, Sonja was living with metastatic HER2-positive breast cancer after spread to lungs and liver, later tailbone and thoracic lymph nodes, and had moved to weekly carboplatin/gemcitabine plus monthly immunotherapy.

Stage IV HER2-Positive Gastric Cancer With Immune Thrombocytopenia During Treatment

Patient Info: Anonymized | Stage IV

Biomarkers: HER2 amplified; PD-L1 CPS 10; pMMR; Claudin18.2 overexpression

Metastatic Site: liver, omentum

CT in March 2024 showed progression with enlarging gastric and omental lymphadenopathy and new liver metastases.

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Stage IV EGFR Non-Small Cell Lung Cancer: Jennifer's Patient Story

Patient Info: Jennifer, Female | Stage IV

Biomarkers: EGFR genomic mutation

Metastatic Site: Not reported

Jennifer is alive more than 5.5 years after a Stage IV adenocarcinoma diagnosis, continuing EGFR-targeted treatment and living with ongoing side effects and surveillance needs.

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Stage IV Lung Cancer: Tina's Patient Story

Patient Info: Tina Powell, Female | Stage IV

As of November 2025, Tina was living with Stage IV lung cancer after 27 chemotherapy rounds over 3 years and was receiving an antibody-drug conjugate in a clinical trial.

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Stage IV ALK Non-Small Cell Lung Cancer: Laura's Patient Story

Patient Info: Laura, Female | Stage IV

Biomarkers: ALK-positive / ALK-rearranged

Metastatic Site: Not reported

Laura was living with incurable Stage IV ALK-positive NSCLC, continuing targeted therapy and regular CT monitoring after trying multiple TKIs and a clinical trial.

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EGFR Non-Small Cell Lung Cancer: Michelle's Patient Story

Patient Info: Michelle Vacca, Female, 40s

Biomarkers: EGFR mutation at recurrence; later rare mutation not named

As of November 2025, Michelle still actively had recurrent NSCLC, but her disease had remained stable on targeted therapy and an investigational kinase inhibitor clinical trial, allowing good quality of life.

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Stage IV ROS1 Non-Small Cell Lung Cancer: Lysa's Patient Story

Patient Info: Lysa, Female, 40s | Stage IV

Biomarkers: ROS1-positive / ROS1-rearranged

Metastatic Site: spine; later new sites not specified

After more than a decade with Stage IV ROS1-positive NSCLC, Lysa was stable on a clinical-trial targeted therapy and no longer needed chemotherapy.

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HER2-positive breast cancer: brain recurrence, T-DXd liver injury, and later progression

Patient Info: Anonymized, Female, 40s | Stage IV

Biomarkers: HER2-positive; hormone receptor-negative; grade 3 infiltrative breast carcinoma

Metastatic Site: brain; thoracic lymph nodes

As of October 2025, the patient had developed brain and thoracic nodal recurrence after HER2-directed treatment, experienced T-DXd-associated liver injury, progressed after later paclitaxel/trastuzumab, and died at home in December 2024 under palliative care.

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Stage IV Invasive Ductal Carcinoma: Dalitso's Patient Story

Patient Info: Dalitso, Female, Under 40 | Stage IV

Metastatic Site: bone: spine, ribs, sternum, hip sockets

Dalitso had severe Stage IV bone-metastatic breast cancer with hospice-level symptoms and later bone progression, but subsequent imaging after a new treatment approach showed no visible active disease.

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Stage IV Invasive Lobular Carcinoma: Nikoo's Patient Story

Patient Info: Nikoo, Female, 40s | Stage IV

Biomarkers: BRCA1/2 negative; PIK3 mutation reported on liquid biopsy

Metastatic Site: Peritoneal/abdominal lining; abdominal lymph nodes

Nikoo had Stage I invasive lobular breast cancer in 2003 and developed Stage IV metastatic recurrence in 2022 after about 19 years. As of October 2025, she was living with metastatic lobular breast cancer, had moved through multiple systemic options, and was participating in a Phase 1 clinical trial.

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Stage I Colorectal Cancer: Jessica's Survivor Story

Patient Info: Jessica, Female, Under 40 | Stage I

Biomarkers: Lynch syndrome

Jessica had Stage I Lynch syndrome-associated rectal cancer treated with an immunotherapy clinical-trial approach rather than chemoradiation or surgery. Midpoint colonoscopy and MRI showed the mass was gone, and she completed 7 infusions over 6 months. As of September 2025, she was in survivorship with intensive Lynch syndrome surveillance.

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Stage III Ovarian Cancer: Mary's Survivor Story

Patient Info: Mary Catherine Riley, Female, 40s | Stage III

After a 2023 recurrence, Mary achieved a complete response within 1 year on avutometinib and defactinib. She continues the approved combination with quarterly CT scans and monthly labs and has no evidence of disease.

Stage III Triple-Negative Breast Cancer: Paula's Survivor Story

Patient Info: Paula Jones, Female, 40s | Stage III

Biomarkers: Triple-negative breast cancer; BRCA1 mutation

As of July 2025, Paula had remained cancer-free for more than 15 years after Stage IIIC triple-negative breast cancer treatment and was training to become a mammography technologist.

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Limited-stage small-cell lung cancer: complete response after salvage chemoradiation and continued serplulimab

Patient Info: Anonymized, Male, 40s

Biomarkers: PD-L1 CPS 1

As of May 13, 2025, after salvage chemoradiation, irinotecan, and continued serplulimab for isolated supraclavicular nodal recurrence, he remained in complete response with no radiologic recurrence or metastasis on brain MRI and CT of the neck, chest, and abdomen.

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Stage II EGFR Lung Cancer: Samantha's Patient Story

Patient Info: Samantha Vaughn, Female | Stage II

Biomarkers: EGFR mutation

Samantha had Stage II EGFR-mutated lung cancer removed surgically and was receiving post-operative daily Tagrisso through a clinical trial. As of June 2025, she reported clear results so far but remained on active targeted therapy.

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Stage IV HER2-Positive Breast Cancer: Kathleen's Patient Story

Patient Info: Kathleen McEvoy-Schufreider, female, 60s | Stage IV

Biomarkers: HER2-positive

Metastatic Site: liver, bones

Kathleen continued long-term treatment for metastatic breast cancer, including infusions every 3 weeks after resuming the PATINA regimen outside the trial.

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Stage IV HER2-Positive Breast Cancer: Jennifer's Survivor Story

Patient Info: Jennifer Masters, Female, 60s | Stage IV

Biomarkers: HER2-positive

Metastatic Site: Chest wall/skin near surgery incision; lymph nodes

As of May 2025, Jennifer had no reported recurrence for several years after Stage IV HER2-positive metastatic breast cancer responded completely to clinical-trial treatment with T-DM1 and neratinib; she continued annual Cleveland Clinic visits and remained active with family and volunteering.

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Stage IV HR-Positive Invasive Ductal Carcinoma: Samantha's Patient Story

Patient Info: Samantha, Female, Under 40 | Stage IV

Biomarkers: ER-positive; PR-positive; HER2-positive

Metastatic Site: Rib; spine; pelvis

After a mixed response on the radium trial, Samantha changed to anastrozole and abemaciclib. She described the newer hormone-targeted combination as easier to tolerate and working better while remaining in ongoing treatment.

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Stage IV KRAS Lung Cancer: Rosemary's Patient Story

Patient Info: Rosemary Conway, female, 60s | Stage IV

Biomarkers: KRAS mutation

After 14 months on daraxonracib in a clinical trial, Rosemary’s Stage IV lung cancer had stopped growing and she had returned to walking and lifting weights.

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Stage IV Triple-Negative Breast Cancer: Maggie's Survivor Story

Patient Info: Maggie, Female | Stage IV

Biomarkers: ER-negative; PR-negative; HER2-negative

Metastatic Site: lungs, lymph nodes; possible liver

Diagnosed in 2022 with de novo Stage IV triple-negative breast cancer involving the lungs and lymph nodes, with possible liver involvement. After entering a chemotherapy/immunotherapy clinical trial, she reported being cancer-free / no evidence of disease for well over 1 year as of February 2025.

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ALK-Fusion Small Cell Lung Cancer Responding to ALK-Targeted Therapy

Patient Info: Anonymized, female, 40s | Stage IV

Biomarkers: EML4-ALK fusion

Metastatic Site: brain

After several earlier treatments stopped controlling the cancer, ALK-targeted iruplinalkib produced a partial response and was still controlling disease after more than 8 months.

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Stage IV HER2-Positive Colorectal Cancer: Emily's Patient Story

Patient Info: Emily King, Female, Under 40 | Stage IV

Biomarkers: HER2-positive

Metastatic Site: lungs

Emily remained on active treatment for metastatic HER2-positive colon cancer, and her current Boston treatment had shrunk the cancer by 20% with fewer side effects.

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