Stage IIIA pleomorphic lung cancer treated with surgery, chemotherapy, and radiation

Patient Info: Anonymized, Male, Under 40 | Stage III

Alive 14 months after surgery without evidence of tumor recurrence after complete resection, adjuvant chemotherapy, oral S-1, and radiation.

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Stage IV lung squamous cell carcinoma with liver metastasis treated with chemotherapy and 90Y radioembolization

Patient Info: Anonymized, Female, 50s | Stage IV

Metastatic Site: liver

After treatment for liver metastasis, PET CT 2 months after 90Y radioembolization showed complete tumor response without residual tumor, and she was alive without active disease.

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Recurrent Stage III Ovarian Cancer in a BRCA2 Carrier Treated Over Many Years

Patient Info: Anonymized, 40s | Stage III

Biomarkers: BRCA2 mutation

She later developed a separate aggressive oral squamous cell carcinoma and died in 2011 from acute airway obstruction during progression of that cancer.

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Stage III Ovarian Cancer in a BRCA1 Carrier With Long-Term Disease Control

Patient Info: Anonymized, 60s | Stage III

Biomarkers: BRCA1 mutation

At the latest follow-up in January 2012, she had no recurrence of ovarian cancer and was well.

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Recurrent Stage III Ovarian Cancer in a BRCA1 Carrier Treated With Multiple Therapies

Patient Info: Anonymized, female, 40s | Stage III

Biomarkers: BRCA1 mutation

By late 2011, hilar nodal disease was slowly progressing and bevacizumab was started for the recurrent ovarian cancer.

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Recurrent Stage III Ovarian Cancer Complicated by Severe Kidney Injury

Patient Info: Anonymized, female, 70+ | Stage III

After further intra-abdominal cancer progression and severe kidney injury, she developed seizures, encephalopathy, and limb ischemia and died 1 week after hospitalization in May 2011.

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Recurrent Ovarian Cancer With Treatment-Related Kidney Failure and Dialysis

Patient Info: Anonymized, female, Under 40

The ovarian cancer later progressed with enlarging pelvic masses, rectal obstruction, and intestinal perforation, and she died in February 2011.

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Stage III Triple-Negative Breast Cancer: Bridgette's Survivor Story

Patient Info: Bridgette, Female, 60s | Stage III

Biomarkers: Triple-negative breast cancer

Bridgette completed treatment and described herself as being in remission and free of cancer. Fear of recurrence continued to affect her survivorship.

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Recurrent Ovarian Cancer With Severe Kidney Injury During Long-Term Treatment

Patient Info: Anonymized, female, 60s

Despite severe chronic kidney disease, later chemotherapy produced some regression of the progressing ovarian cancer with each sequential regimen.

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Stage IV large-cell lung cancer with adrenal metastasis: no recurrence after R0 surgery

Patient Info: Anonymized, Male, 60s | Stage IV

Biomarkers: Marker profile supported large-cell lung carcinoma: CK7/CEA/Ber-EP4 positive, with neuroendocrine and prostate markers negative.

Metastatic Site: left adrenal gland

Six months after combined lung and adrenal surgery with R0 resection, he had no evidence of recurrence.

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Stage III Ovarian Cancer in a BRCA1 Carrier Treated With Long-Term Maintenance Therapy

Patient Info: Anonymized, 50s | Stage III

Biomarkers: BRCA1 mutation

After long-term maintenance therapy, she had no evidence of ovarian cancer at the latest follow-up.

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Gastric adenocarcinoma first presents with painful eye and orbital metastases

Patient Info: Anonymized, Male, 60s | Stage IV

Metastatic Site: left uvea, orbit, sclera, optic nerve

He died 6 months later after treatment for metastatic gastric cancer.

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Stage IV lung adenocarcinoma with brain metastasis: partial remission after pemetrexed/cisplatin and AOSD-like paraneoplastic syndrome

Patient Info: Anonymized, Male, 50s | Stage IV

Biomarkers: No tumor molecular biomarkers reported. AOSD-like syndrome had high ferritin, inflammation markers, and RF/ANA negative.

Metastatic Site: brain

As of November 2011, pemetrexed/cisplatin produced partial remission of Stage IV lung adenocarcinoma and controlled the AOSD-like paraneoplastic syndrome without recurrent fever, rash, or arthralgia.

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Recurrent HER2-amplified breast cancer: complete remission on trastuzumab-based therapy

Patient Info: Anonymized, Female, 40s | Stage Metastatic/Advanced

Biomarkers: Primary tumor was ER/PR negative and HER2 not amplified. Recurrent lymph-node disease became ER/PR positive and HER2 amplified by FISH.

Metastatic Site: left axillary and infraclavicular lymph nodes

After HER2-amplified nodal recurrence, paclitaxel plus trastuzumab produced complete clinical remission; she continued trastuzumab monotherapy with tolerable neuropathy.

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Sigmoid colon cancer with later inguinal lymph-node metastasis: surgery, FOLFOX, FOLFIRI, and cetuximab

Patient Info: Anonymized, Male, 60s | Stage IV

Biomarkers: CEA was elevated at diagnosis and recurrence. Metastatic lymph node was CK20 positive/CK7 negative; EGFR mutation status not reported.

Metastatic Site: left inguinal lymph node

Apparently disease-free 8 months after surgical removal of the left inguinal lymph-node metastasis followed by FOLFIRI plus cetuximab.

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Right breast ductal carcinoma with unusual sentinel-node drainage treated with lumpectomy and adjuvant therapy

Patient Info: Anonymized, Female, 40s

After lumpectomy, negative sentinel lymph node evaluation across 3 drainage territories, chemotherapy, radiotherapy, and hormone therapy, she remained free of disease 2 years and 6 months after surgery.

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Lobular breast cancer with extraocular muscle and lung metastases: ocular improvement after radiotherapy and tamoxifen

Patient Info: Anonymized, Female, 60s | Stage IV

Biomarkers: Original breast cancer: ER-negative; PR-negative. Extraocular muscle metastasis/recurrent disease: ER strongly positive; PR strongly positive.

Metastatic Site: bilateral extraocular muscles, right upper lobe lung,…

At 18 months after presentation with extraocular muscle metastases, PET showed no abnormality, diplopia had resolved, and ocular motility had markedly improved, with mild bilateral ptosis remaining.

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Triple-negative glycogen-rich clear cell carcinoma of the breast: chemotherapy, mastectomy, and radiation

Patient Info: Anonymized, Female, 50s | Stage III

Biomarkers: Triple-negative breast cancer with glycogen-rich clear cell features; pathology stains supported breast carcinoma.

Asymptomatic and disease-free 14 months after surgery, additional chemotherapy, and 50 Gy radiotherapy for T4N0M0 triple-negative glycogen-rich clear cell breast carcinoma.

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Stage IV lung adenocarcinoma: partial responses to cisplatin-docetaxel and erlotinib, complicated by fistula

Patient Info: Anonymized, Female, 60s | Stage IV

Biomarkers: Tumor genomic biomarkers not reported. EGFR testing result not reported; erlotinib was used as second-line therapy.

Metastatic Site: contralateral lung, pleura

Metastatic lung adenocarcinoma had partial response to chemotherapy and persistent partial response on erlotinib; after erlotinib was stopped for enterocutaneous fistula, she was alive and well without evidence of lung-cancer progression.

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Stage IV NSCLC with choroidal metastasis responding to intravitreal bevacizumab

Patient Info: Anonymized, Female, 50s | Stage IV

Metastatic Site: choroid of right eye

The right-eye choroidal metastasis showed complete local response after intravitreal bevacizumab, with pain resolution, vision improvement to 20/20, and no residual ocular tumor detected 10 months after treatment began.

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ER-positive breast cancer recurrence after DCIS: chemotherapy, nodal surgery, radiation, and endocrine therapy

Patient Info: Anonymized, Female, 40s

Biomarkers: Recurrent invasive breast cancer: ER-positive; HER2/neu-negative. PR not reported.

Disease-free for 33 months after treatment of ER-positive, HER2-negative invasive breast cancer recurring in the mastectomy skin flap with positive axillary sentinel nodes.

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Localized breast carcinosarcoma: surgery and chemotherapy with no disease at 54 months

Patient Info: Anonymized, Female, 40s

Biomarkers: Breast carcinosarcoma was ER/PR negative, c-erbB2 5%

Under follow-up with no disease at 54 months after excision, modified radical mastectomy, and 6 courses of chemotherapy for localized breast carcinosarcoma.

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Stage IIIA squamous NSCLC: complete pathological response after docetaxel and lobectomy

Patient Info: Anonymized, Male, 60s | Stage III

Complete clinical response after 14 cycles of docetaxel was confirmed as a complete pathological response after right lobectomy.

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HER2-positive breast cancer with isolated adrenal metastasis: adrenalectomy with no recurrence at follow-up

Patient Info: Anonymized, Female, 60s | Stage IV

Biomarkers: Primary breast tumor and adrenal metastasis were HER2-positive and ER/PR negative; adrenal markers supported breast origin.

Metastatic Site: left adrenal gland

Alive in good condition with no evidence of recurrence more than 3 years after adrenalectomy for isolated adrenal metastasis and more than 5 years after the original breast surgery.

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