Metastatic Breast Cancer With Recurrent Severe Hypocalcemia During Treatment - Case 1

Patient Info: Anonymized, female, Under 40 | Stage IV

Biomarkers: ER-positive; PR-positive; HER2-negative

Metastatic Site: bone, liver, ovaries

She died about 9 years after her breast-cancer diagnosis after progression of liver metastases.

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HER2-Positive Metastatic Breast Cancer With Recurrent Severe Hypocalcemia - Case 2

Patient Info: Anonymized, female, 60s | Stage IV

Biomarkers: ER-positive; PR-positive; HER2-positive

Metastatic Site: bone, liver

She died about 7 years after her breast-cancer diagnosis after rapid deterioration from liver metastases.

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Stage II Colorectal Cancer: Savannah's Survivor Story

Patient Info: Savannah Kaspar, Female, Under 40 | Stage II

Biomarkers: Lynch syndrome genetic testing negative

As of March 2024, Savannah had completed partial colectomy and 4 rounds of adjuvant chemotherapy for Stage II sigmoid colon cancer and had entered surveillance with bloodwork every 3 months.

MD AndersonRead more →

Stage III Invasive Lobular Carcinoma: Harvey's Patient Story

Patient Info: Harvey, Male, 50s | Stage III

Biomarkers: Genetic testing negative

Harvey was in active treatment for male Stage IIIC grade 3 ILC after right mastectomy and initiation of AC-T chemotherapy, with radiation and endocrine/targeted therapy planned as of March 2024.

Lobular Breast Cancer AllianceRead more →

Stage IV Ovarian Cancer: Susan's Patient Story

Patient Info: Susan Dunwoody, female | Stage IV

Susan lived for 7 years after her Stage IV ovarian cancer diagnosis and later died from the disease.

MD AndersonRead more →

Stage II Colorectal Cancer: John's Survivor Story

Patient Info: John, Male, Under 40 | Stage II

As of March 2024, John had a complete response to chemotherapy and radiation for Stage II rectal cancer, with the tumor completely gone, no signs of cancer remaining, no surgery needed, and ongoing watch-and-wait monitoring.

Cleveland ClinicRead more →

Stage II Triple-Negative Breast Cancer: Chance's Survivor Story

Patient Info: Chance Osborne, Female, Under 40 | Stage II

Biomarkers: ER-negative; PR-negative; HER2-negative; BRCA1 mutation

As of March 2024, Chance Osborne was a young Stage II TNBC survivor with a BRCA1 mutation, sharing her experience with chemotherapy, double mastectomy recovery, and advocacy.

EGFR L858R/S768I lung adenocarcinoma with more than 5 years of survival after targeted therapy

Patient Info: Anonymized, male, 60s | Stage IV

Biomarkers: EGFR L858R and S768I compound mutation

Metastatic Site: bone, brain

He died on August 15, 2022, about 5 years and 4 months after his April 2017 presentation; afatinib had provided more than 3 years of disease control before later bone and brain progression.

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Stage II HR-Positive Invasive Ductal Carcinoma: Dorian's Survivor Story

Patient Info: Dorian de Salvo, Female | Stage II

Biomarkers: ER-positive; PR-positive; HER2-positive

As of March 2024, Dorian had a complete response to TCHP chemotherapy, clear surgical margins, and no lymph-node involvement after surgery, with radiation completed and additional care still expected for several months.

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Stage II lung adenocarcinoma with severe atezolizumab-related myocarditis after surgery

Patient Info: Anonymized, female, 40s | Stage II

Biomarkers: PD-L1 TPS 50%

More than 1 year after atezolizumab was discontinued, there was no recurrence of the lung cancer.

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Stage IV ALK Lung Adenocarcinoma: Keegan's Survivor Story

Patient Info: Keegan Murphy, Male, 40s | Stage IV

Biomarkers: ALK fusion mutation

Metastatic Site: Lungs; lymph nodes; ribs/bone; abdomen

As of March 2024, Keegan had gone from Stage IV ALK-positive lung adenocarcinoma with tumors in the lungs, lymph nodes, ribs, and abdomen to no evidence of disease after alectinib and surgery.

MD AndersonRead more →

How I KNEW I Had COLON CANCER

Patient Info: Courtney, Female | Stage III

As of March 2024, Courtney was nearly 3 years in remission after surgery and adjuvant chemotherapy for Stage IIIA colorectal cancer, with follow-up every 6 months.

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Metastatic gastric cancer with Krukenberg tumors complicated by emergency bleeding

Patient Info: Anonymized, female, 60s | Stage IV

Metastatic Site: bilateral ovaries/adnexa (Krukenberg tumors)

She recovered well from emergency surgery for bleeding from a torsed Krukenberg tumor and was attending regular oncology follow-up 6 months later.

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Stage III squamous lung cancer controlled during treatment while a second pancreatic cancer developed

Patient Info: Anonymized, female, 50s | Stage III

Biomarkers: KRAS exon 2 mutation

She died in March 2022. Her Stage III lung cancer had remained controlled for about 18 months, while a separate pancreatic cancer developed and progressed.

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Stage IIIB to metastatic rectal cancer: setback and treatment journey

Patient Info: Justine, Female, Under 40 | Stage IV

Metastatic Site: Liver; lung

As of March 2024, Justine was living with metastatic rectal cancer involving liver and lung, described as treatable but not curable, after surgery, permanent ileostomy, IV chemotherapy, liver ablation, lung SBRT, and Y-90 liver radioembolization.

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Colon cancer recurrence at a surgical drain site

Patient Info: Anonymized, Male

He recovered well after abdominal-wall excision and was followed every 3–6 months, with no clinical signs of further recurrence or metastasis.

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Stage IV Colorectal Cancer: Linda's Patient Story

Patient Info: Linda Hartong, Female, 40s | Stage IV

Metastatic Site: liver

Linda was feeling well enough to continue treatment after right liver resection and 10 chemotherapy cycles, with further surgery and 2 final cycles planned.

Fight Colorectal CancerRead more →

Stage IV lung adenocarcinoma presenting as a painful thigh metastasis

Patient Info: Anonymized, female, 40s | Stage IV

Metastatic Site: right thigh soft tissue/muscle, bilateral iliac bones…

After 9 months of therapy, the lung lesion had a partial response and the painful thigh mass had markedly decreased, although she remained unable to walk.

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Jason Randall: stage IV colorectal cancer and liver metastases

Patient Info: Jason Randall, Male, Under 40 | Stage IV

Metastatic Site: Liver; lung; tailbone/sacrum/pelvis

As of March 2024, Jason was 2.5 years off chemotherapy and 16 months with no evidence of disease after treatment for Stage IV rectosigmoid colorectal cancer.

City of HopeRead more →

Small cell lung cancer with dermatomyositis improving after chemo-immunotherapy

Patient Info: Anonymized, male, 70+

After treatment began, muscle enzymes fell and his strength, skin symptoms, and overall condition improved.

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Small cell lung cancer with dermatomyositis and fatal immune-related toxicity

Patient Info: Anonymized, male, 50s

He died 3 weeks after starting treatment after developing severe skin toxicity thought to be a fatal immune-related adverse event, with possible infection and sepsis.

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Left Breast Cancer in a BRCA2 Carrier Treated With Mastectomy, Chemotherapy, and an Arm Port

Patient Info: Anonymized, female, Under 40

Biomarkers: Hormone receptor-positive; HER2-negative; pathogenic BRCA2 variant

At 17 months after surgery, she was free from disease and reported good quality of life and satisfaction with reconstruction and the arm port.

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Triple-Negative Metaplastic Breast Cancer Treated With Chemotherapy, Oncoplastic Surgery, and Radiation

Patient Info: Anonymized, female, 40s

Biomarkers: Triple-negative

Follow-up imaging and clinical examinations showed no residual or recurrent disease for 2 years after treatment.

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BRCA1-Mutated Ovarian Cancer Responding to Niraparib After Olaparib Progression

Patient Info: Anonymized, Female, 60s

Biomarkers: Germline BRCA1 pathogenic variant c.188T>A; CA-125 4

Two months after starting niraparib, imaging showed a partial response and CA-125 normalized. At 15 months, she had achieved a complete response and remained progression-free while niraparib continued.

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