Adrenal metastasis from gastric cancer causing adrenal insufficiency

Patient Info: Anonymized, male, 60s | Stage IV

Biomarkers: HER2-negative, PD-L1-negative

Metastatic Site: right adrenal gland

More than 17 months after the metastatic relapse, he was clinically well with no radiological or biochemical signs of active cancer apart from the residual right adrenal lesion.

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Solitary adrenal metastasis after surgery for gastric large-cell neuroendocrine carcinoma

Patient Info: Anonymized, male | Stage IV

Metastatic Site: right adrenal gland

Nine months after removal of the adrenal metastasis, he was alive and August 2022 CT showed no new metastases or tumor recurrence.

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Recurrent gastric cancer with bone metastases, venous thrombosis and chylothorax

Patient Info: Anonymized, male, 60s | Stage IV

Metastatic Site: bone

Biopsy-confirmed bone recurrence developed more than a year after surgery. He was too unwell for palliative chemotherapy and died a few months after transition to best supportive care.

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Stage IV gastric adenocarcinoma first detected through an appendiceal metastasis

Patient Info: Anonymized, male, 70+ | Stage IV

Metastatic Site: appendix

He was referred to oncology for Stage IV gastric cancer and started capecitabine chemotherapy.

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Stage IV Gastric Adenocarcinoma: Angel's Survivor Story

Patient Info: Angel | Stage IV

Angel was declared cancer-free in August 2024 and described being NED within 1 year of the Stage IV gastric cancer diagnosis.

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Recurrent gastric cancer with peritoneal spread and a difficult intestinal fistula

Patient Info: Anonymized, female, 70+ | Stage IV

Metastatic Site: peritoneum

About 10 years after her original gastrectomy, recurrent gastric cancer with peritoneal spread progressed despite palliative procedures. She died 3 months after her final reoperation.

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Stage IV Gastric Cancer: Rachel's Patient Story

Patient Info: Rachel Orth, Female, Under 40 | Stage IV

Rachel previously reported stable metastatic gastric cancer while receiving treatment on a phase I clinical trial. She died in June 2025.

Metastatic gastric adenocarcinoma first discovered through a malignant pleural effusion

Patient Info: Anonymized, male, 70+ | Stage IV

Metastatic Site: pleura, lungs, diaphragm, bone

Soon after diagnosis, worsening malignant pleural effusions led to respiratory failure, shock and renal failure. Life-support measures were withdrawn and he was terminally extubated.

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Stage IV gastric cancer with liver metastases cleared after chemotherapy, nivolumab and surgery

Patient Info: Anonymized, male, 60s | Stage IV

Biomarkers: PD-L1-positive, HER2-negative

Metastatic Site: liver

After treatment cleared the gastric and liver lesions, all anticancer therapy was stopped. He remained relapse-free with no evidence of disease for 32 months.

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Stage IV gastric cancer with a TP53 blood finding traced to clonal hematopoiesis

Patient Info: Anonymized, male, 50s | Stage IV

Metastatic Site: distant lymph nodes

At age 57, 3 years 4 months after his Stage IV diagnosis, he remained alive after multiple lines of treatment; progression had occurred before his later-line regimens.

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Metastatic hepatoid gastric adenocarcinoma achieving complete remission with sintilimab

Patient Info: Anonymized, male | Stage IV

Biomarkers: AFP markedly elevated

Metastatic Site: liver

By the fifth sintilimab cycle, gastroscopy showed no gastric tumor, CT showed no liver metastases and AFP had normalized; complete remission was confirmed and remained stable during subsequent treatment.

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HER2-positive metastatic gastric cancer responding to trastuzumab deruxtecan rechallenge

Patient Info: Anonymized, male, 60s | Stage IV

Biomarkers: HER2-positive

Metastatic Site: liver

After trastuzumab deruxtecan was restarted, his symptoms improved after the first cycle and imaging showed tumor shrinkage after 3 cycles. He was still receiving treatment without progression at the latest follow-up.

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Long-term complete response to nivolumab after recurrent Stage IV gastric cancer

Patient Info: Anonymized, female, 70+ | Stage IV

Biomarkers: HER2-negative, PD-L1 CPS ≤1

Metastatic Site: peritoneum, distant lymph nodes

About 7 years after surgery and roughly 3 years after starting nivolumab, CT showed no recurrent nodules or enlarged lymph nodes. She remained on nivolumab with a complete clinical response, had regained weight and returned to work.

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Stage IV Gastric Adenocarcinoma: Doran's Patient Story

Patient Info: Doran Barro, Female, 70+ | Stage IV

Metastatic Site: peritoneum|liver|lungs

Doran entered hospice on September 24 and died on September 30, 2014, about 5 months after diagnosis.

Stage IV Gastric Cancer: Ernie's Patient Story

Patient Info: Ernie Pierce, Male, 60s | Stage IV

He died on July 8, 2009, after living with Stage IV gastric cancer for about 15 months.

Stage IV Gastric Cancer: Jeanne's Patient Story

Patient Info: Jeanne Guercia, Female, 70+ | Stage IV

She was living with Stage IV stomach cancer, with her husband serving as her primary caregiver.

Stage IV Gastric Cancer: Buddy's Patient Story

Patient Info: Buddy (Bernard), Male, 70+ | Stage IV

Metastatic Site: adrenal gland

Buddy died on November 9, 2012, a little more than 3 months after diagnosis.

Stage IV Gastric Cancer: Karen's Patient Story

Patient Info: Karen Lucas, Female, 60s | Stage IV

Karen died peacefully at home on January 30, 2014, at age 62, a little over 1 year after her Stage IV diagnosis.

Stage IV Gastric Cancer: Patricia's Patient Story

Patient Info: Patricia Etienne, Female, 50s | Stage IV

Six months after diagnosis, Patricia reported feeling better physically, mentally, emotionally, and spiritually and had resumed exercise and church activities.

Kidney Injury During Nivolumab Treatment for Stage IV Gastric Cancer

Patient Info: Anonymized, Male, 60s | Stage IV

Kidney function and proteinuria improved after nivolumab was stopped, but the gastric cancer progressed. Restarted nivolumab was ineffective, and treatment was changed to irinotecan.

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Stage IV HER2-Positive Gastric Cancer: Bryan's Patient Story

Patient Info: Bryan Chagolla, Male, Under 40 | Stage IV

Biomarkers: HER2-positive

Metastatic Site: liver

Bryan had a strong response to trastuzumab deruxtecan in 2021. He died on May 13, 2022, surrounded by loved ones.

Stage IV gastric cancer treated with chemotherapy and hyperthermia in a patient with a vagus nerve stimulator

Patient Info: Anonymized, male, 50s | Stage IV

Metastatic Site: para-aortic lymph nodes, peritoneum

The gastric tumors and lymph-node disease initially shrank during treatment, but peritoneal dissemination developed. He died from progressive gastric cancer 8 months after treatment began.

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Stage IV gastric cancer with low platelets managed so chemotherapy could continue

Patient Info: Anonymized, female, 60s | Stage IV

Chemotherapy was able to continue after partial splenic embolization, but the gastric cancer later progressed and she died from the disease.

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Stage IV gastric cancer with low platelets managed so chemotherapy could continue — Case 2

Patient Info: Anonymized, female, 70+ | Stage IV

After partial splenic embolization, her platelet count recovered and thrombocytopenia did not recur. She was receiving second-line ramucirumab plus paclitaxel at the latest follow-up.

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