Stage IV RET-fusion transverse colon cancer: partial response to selpercatinib after capecitabine progression

Patient Info: Anonymized, Female, 70+ | Stage IV

Biomarkers: Colon cancer had RET fusion, KRAS copy-number gain, low TMB, and no KRAS/NRAS/BRAF hotspot mutations.

Metastatic Site: liver

As of May 2026, she remained on reduced-dose selpercatinib with tolerable toxicity, substantial partial response in liver metastases and the primary tumor, and progression-free survival exceeding 14 months.

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Stage III Colorectal Cancer: Amber's Survivor Story

Patient Info: Amber Mike, Female, 40s | Stage III

As of February 2026, Amber had completed Stage III colorectal cancer treatment, was doing well under close monitoring with tumor markers every 3 months, and was rebuilding life through survivorship, therapy, travel, and advocacy.

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Stage IV Colorectal Cancer: Natasha's Patient Story

Patient Info: Natasha McCants, Female, 40s | Stage IV

Biomarkers: Unspecified tumor mutation identified by molecular testing

Metastatic Site: Liver; lungs; ovary

As of February 2026, Natasha’s Stage IV colorectal cancer was under control after mutation-informed treatment at City of Hope, but Signatera showed potentially active cells and she remained on daily chemotherapy pills.

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I Survived Childhood Cancer. Then I Was Diagnosed AGAIN at 18.

Patient Info: Maria, Female, Under 40

Biomarkers: Mosaic variegated aneuploidy syndrome 3; prior colon polyp genetic testing negative before final diagnosis

The early colon cancer was removed during colonoscopy, but Maria continues long-term surveillance for recurrent polyps and survivorship effects related to childhood Wilms tumor and MVA3.

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Stage IV MSI-H KRAS-mutant colorectal adenocarcinoma: severe pembrolizumab-associated hypercalcemia resolved with steroids and zoledronic acid

Patient Info: Anonymized, Female, 70+ | Stage IV

Biomarkers: KRAS G12xa mutation; MSI-H; BRAF wild type; NRAS wild type; PTH low-normal

Metastatic Site: liver

After the second pembrolizumab dose, severe hypercalcemia and electrolyte abnormalities resolved with high-dose glucocorticoids, zoledronic acid, and supportive care; cancer response was not yet described.

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Rectal cancer surgery complicated by postoperative intestinal obstruction and resistant Enterococcus infection

Patient Info: Anonymized, Female, 50s

Biomarkers: No cancer biomarkers reported; wound culture grew Enterococcus gallinarum with intrinsic resistance to vancomycin and several other agents

After postoperative intestinal obstruction and severe intra-abdominal infection, her temperature normalized, infection markers returned to normal, antibiotics were stopped, and she was discharged after clinical improvement for continued post-surgical care.

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Colorectal Cancer: Donna's Survivor Story

Patient Info: Donna Marie Caruso, Female, 70+

As of November 2025, Donna was in rectal cancer survivorship after surgery, radiation and chemotherapy, with improved quality of life through support for low anterior resection syndrome; no formal stage or NED status was stated.

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Colon cancer patient with insulin autoimmune syndrome after FOLFOX, bevacizumab, and omeprazole

Patient Info: Anonymized, Male, 70+

Biomarkers: No cancer biomarkers reported. Insulin autoimmune syndrome followed chemotherapy/omeprazole exposure.

As of November 2025, the rare insulin autoimmune syndrome episode had improved after glucose supplementation and prednisone acetate, with blood glucose returning to the normal range during postoperative colon cancer treatment.

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Stage I low rectal adenocarcinoma: ileal J-pouch salvage reconstruction after rectovaginal fistula

Patient Info: Anonymized, Female, 50s | Stage I

Biomarkers: CEA remained within normal range during follow-up; no molecular biomarkers reported

At 5 years after salvage reconstruction, colonoscopy showed no recurrence, stricture, or pouch complication; annual CT showed no local recurrence or distant metastasis; CEA remained normal and bowel function was satisfactory.

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Kidney complication after switching colorectal cancer chemotherapy regimens

Patient Info: Anonymized, Male, 70+ | Stage IV

Metastatic Site: liver

The cancer had worsening liver metastases when FTD/TPI began. After treatment was stopped, steroid therapy resolved edema within 1 month and proteinuria returned to baseline 2.5 months after admission; the later cancer course was not established.

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Stage IV transverse colon cancer with NTRK fusion: entrectinib response followed by fatal PTTM

Patient Info: Anonymized, Male, 70+ | Stage IV

Biomarkers: RAS/BRAF wild type, low TMB. CEA and CA19-9 were elevated before entrectinib and fell with response.

Metastatic Site: peritoneum, greater omentum, pleura,…

He died 7 weeks after hospitalization from pulmonary tumor thrombotic microangiopathy causing severe pulmonary hypertension and right-heart failure, despite biochemical and ascites response to entrectinib.

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Metastatic colorectal cancer during pregnancy: chemotherapy and liver metastases

Patient Info: Anonymized, Female, Under 40 | Stage IV

Biomarkers: Mismatch-repair deficient; KRAS ; BRAF not detected; CEA 38 ug/L; Lynch syndrome family history

Metastatic Site: liver, porta hepatis lymph nodes, retroperitoneal…

After initial response to FOLFOX, she developed bowel obstruction after moving closer to family and died during that admission after conservative management.

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Stage IV cecum cancer with liver and ovarian metastases: ramucirumab-related nephrotic syndrome and glomerular microangiopathy

Patient Info: Anonymized, Female, 50s | Stage IV

Biomarkers: Cancer biomarkers were not reported. Kidney injury workup showed severe protein leakage and biopsy-proven glomerular microangiopathy.

Metastatic Site: liver, right ovary

The liver metastasis shrank after XELOX plus bevacizumab and metastatic liver/ovarian sites were resected, but ramucirumab-based second-line therapy was stopped after nephrotic syndrome and severe glomerular microangiopathy; blood pressure and proteinuria improved with telmisartan.

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Metastatic rectal cancer treated during pregnancy

Patient Info: Anonymized, Female | Stage IV

Biomarkers: CEA within normal limits at diagnosis

Metastatic Site: distant lymph nodes including para-aortic,…

Rectal bleeding stopped after chemotherapy, and PET-CT after cycle 3 showed a partial response in the rectal tumour and several involved lymph-node regions.

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Colorectal Cancer: Chrystie's Patient Story

Patient Info: Chrystie, Female, Under 40 | Stage Metastatic/Advanced

Chrystie died at home on December 19, 2008, after advanced unresectable colon cancer, repeated infections, chemotherapy, unsuccessful surgical attempts, and 9 weeks of hospice care.

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Colon cancer surgery complication: fistula after extensive pelvic surgery and radiation

Patient Info: Anonymized, Female | Stage IV

Metastatic Site: upper vaginal wall; lungs

She remained alive after treatment for metastatic colorectal cancer and recovered without clinical fistula recurrence at 1- and 2-month postoperative follow-up.

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Hidden bowel cancer first discovered through a rare nerve disorder (Morvan syndrome)

Patient Info: Anonymized, Male

The tumour was completely resected with no nodal involvement, and no further cancer treatment was required; neurological recovery was partial.

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Hidden colon cancer first discovered through a rare brain/nerve inflammation

Patient Info: Anonymized, Male | Stage II

At 1 year he was asymptomatic and off treatment, with no neurological deficits and a normal repeat PET scan.

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From Fatigue to Stage 4 Colon Cancer in Months: Trevor Maxwell’s Story

Patient Info: Trevor Maxwell, Male, 40s | Stage IV

Metastatic Site: Liver

As of August 2023, Trevor was living with Stage IV metastatic colon cancer and continued to describe his prognosis as uncertain while focusing on mental health and community support for men with cancer.

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Colorectal cancer causing severe hip/back pain and kidney swelling

Patient Info: Anonymized, Male | Stage IV

Biomarkers: MLH1, MSH2, MSH6 and PMS2 expression retained; metastatic cells CK20-

Metastatic Site: distant lymph nodes; left psoas muscle /…

He had active metastatic colorectal cancer with malignant psoas syndrome; his condition worsened after the second palliative FOLFOX cycle and chemotherapy was discontinued.

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Stage IV Colorectal Cancer: JJ's Patient Story

Patient Info: JJ, Male, Under 40 | Stage IV

Biomarkers: Microsatellite-mutated disease mentioned in clinical-trial context; exact MSI/MMR result not otherwise specified

Metastatic Site: Abdominal wall; lymph nodes; stomach/intestinal outlet…

As of January 2023, JJ was living with incurable Stage IV colon cancer on pembrolizumab/Keytruda clinical-trial infusions every 3 weeks; the trial had kept the abdominal tumor mass from spreading and had helped him live beyond the prognosis he feared, but it was not described as curative.

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Colorectal Cancer: Dan's Survivor Story

Patient Info: Dan Gut, Male, Under 40

As of March 2022, Dan had recovered quickly after minimally invasive total colectomy for extensive precancerous colon polyps and intramucosal carcinoma, did not need chemotherapy, and reported better energy while adapting diet and bowel habits.

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Stage IV Colorectal Cancer: Cindi's Survivor Story

Patient Info: Cindi, Female, 60s | Stage IV

Metastatic Site: Liver; abdominal lining/peritoneum

As of March 2022, Cindi had no recurrence more than 1 year after a clinical trial with nivolumab, investigational anti-tumor vaccine, chemotherapy, and surgery produced a complete pathologic response with no living cancer cells.

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Severe immune thrombocytopenia during treatment for metastatic colon cancer

Patient Info: Anonymized, Female, 50s | Stage IV

Biomarkers: KRAS-mutated; microsatellite stable; BRAF-wild type.

Metastatic Site: bilateral ovaries; pelvis; peritoneum; mesenteric…

After multiple metastatic recurrences and treatment changes, she died from progressive colon cancer; oxaliplatin had been permanently stopped after antibody-confirmed immune thrombocytopenia.

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