Colon Cancer With an MLH1 Deletion and Lynch Syndrome

Patient Info: Anonymized, Male, Under 40 | Stage III

Biomarkers: dMMR with loss of MLH1 and PMS2. Familial MLH1 c.1057_1060delGCTG frameshift deletion identified; its clinical significance had not previously been reported.

The colon cancer progressed rapidly despite postoperative and second-line therapy, and he died from multiple organ failure one week after pembrolizumab was started.

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Stage IV Colorectal Cancer: Lina's Patient Story

Patient Info: Lina | Stage IV

Lina was living with Stage IV colorectal cancer 2–3 years after diagnosis after stopping chemotherapy, radiation, and immunotherapy.

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Colorectal Cancer: Michelle's Patient Story

Patient Info: Michelle

Michelle underwent partial colectomy, chemotherapy and immunotherapy after a colon tumor was found during evaluation of pain, bowel changes and blood in the stool.

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Stage IV Colorectal Adenocarcinoma: Alecia's Patient Story

Patient Info: Alecia | Stage IV

She remains on pembrolizumab and reports that her scans have looked good.

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