Stage IV Colorectal Adenocarcinoma: Lauren's Patient Story

Patient Info: Lauren, Female, 40s | Stage IV

Biomarkers: No actionable biomarkers reported; tumor testing suggested Lynch syndrome/hereditary pattern was unlikely; germline genetic testing pending

Lauren had Stage IV signet-ring cell colon cancer diagnosed after obstruction and emergency surgery with colostomy. As of July 2025, she was receiving traditional colorectal chemotherapy and awaiting germline genetic testing; remission was not stated.

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Stage 4 colorectal cancer: complete response with panitumumab and FOLFOX4

Patient Info: Anonymized, Female, 60s | Stage IV

Biomarkers: KRAS/NRAS/BRAF wild type; MSS/pMMR; HER2 not overexpressed. CEA and CA19-9 were elevated.

Metastatic Site: periaortic and pelvic lymph nodes; left ovary/adnexa

As of November 2024, she was alive and continuing second-line FOLFIRI with stable disease after prior complete remission on panitumumab plus FOLFOX4 and later progression with ovarian metastasis.

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Stage III Colorectal Cancer: Paige's Patient Story

Patient Info: Paige Cipher, Female, Under 40 | Stage III

Paige had Stage III rectal cancer and was still in treatment. After 6 rounds of chemotherapy, the tumor had shrunk but was not gone; as of June 2025, she had just completed round 7, had 1 more round planned, and expected surgery in about 3 weeks.

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Stage III Colorectal Cancer: Jackson's Survivor Story

Patient Info: Jackson, Male, Under 40 | Stage III

Jackson completed surgery and chemotherapy for Stage III colon cancer. After his final infusion on January 28, 2025, Signatera was negative, chest and abdomen CTs were clear, tumor-marker bloodwork was negative, and he was declared in remission/no evidence of disease; a later CT in June 2025 was also clear.

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Colorectal Cancer: Julie's Patient Story

Patient Info: Julie Goodrich

Nearly 2 years after surgery and 12 rounds of chemotherapy, Julie described herself as doing well.

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Stage IV Colorectal Cancer: Jay's Survivor Story

Patient Info: Jay, Male, 40s | Stage IV

Metastatic Site: liver

Jay was diagnosed with Stage IV colon cancer in 2013 with extensive liver metastases. After surgery, systemic chemotherapy, hepatic arterial infusion pump therapy, liver resection, ablations, and prolonged chemotherapy, he became clear by 2016 and later described long-term survivorship.

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Metastatic colorectal cancer treated with chemotherapy, cytoreductive surgery and HIPEC

Patient Info: Anonymized, Female, 40s | Stage IV

Metastatic Site: peritoneum, liver

She recovered sufficiently to be discharged home after cytoreductive surgery with HIPEC despite postoperative bone-marrow suppression, anastomotic dehiscence and pelvic sepsis.

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Metastatic colon cancer: soft-tissue and adrenal metastases responding to FOLFIRI plus bevacizumab

Patient Info: Anonymized, Female, 60s | Stage IV

Biomarkers: KRAS codon 146 mutation; BRAF wild type. CK20 and Ki-67 supported colorectal metastasis; CEA/CA19-9 were elevated.

Metastatic Site: lungs; left arm/biceps soft tissue; right…

As of May 2025, metastatic colon cancer involving soft tissue, muscle, lung history, and right adrenal gland had regressed after 12 months of FOLFIRI plus bevacizumab, and the patient was alive 1 year after chemotherapy completion.

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MSI-H locally advanced right colon cancer: pathologic complete response after oxaliplatin, capecitabine, and immunotherapy

Patient Info: Anonymized, Female, 60s

Biomarkers: MSI-H on tumor gene testing

After oxaliplatin, capecitabine, and sindilizumab conversion therapy followed by laparoscopic radical right hemicolectomy, postoperative pathology showed no viable tumor cells and tumor regression grade 0 complete response.

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Stage III Colorectal Cancer: James's Survivor Story

Patient Info: James, Male | Stage III

James had Stage IIIC / possible Stage IV rectal cancer with major lymph node involvement and an uncertain liver spot. After chemotherapy, radiation, multiple surgeries, permanent colostomy, and adjuvant chemotherapy, he later reported no evidence of disease.

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Metastatic rectal cancer responding well after intensive treatment despite severe chemotherapy complications

Patient Info: Anonymized, Male, 40s | Stage IV

Biomarkers: KRAS exon 4 mutation, BRAF wild-type, PD-L1 CPS 2

Metastatic Site: liver, lung

After more than 14 months of treatment, the primary rectal tumor and most lung metastases had been resected, liver lesions had largely regressed, and he was described as near NED while continuing maintenance capecitabine plus bevacizumab.

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Colorectal Cancer: Crystal's Survivor Story

Patient Info: Crystal, Female

Crystal completed limited chemotherapy and multiple major surgeries for colon cancer complicated by bladder involvement and infection risk. She lost her bladder and adapted to ostomy changes. No explicit NED, recurrence, or active-disease status was given.

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Metastatic Colorectal Cancer With NRG1 Fusion Controlled for Years With Afatinib

Patient Info: Anonymized, female, 40s | Stage IV

Biomarkers: MATN-NRG1 fusion; no KRAS alteration detected

Afatinib controlled her metastatic colorectal cancer for 136 weeks. After resection of the remaining target lesion in September 2022, she remained alive with no progression as of October 2024.

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NRG1-Fusion Colorectal Cancer Progressing on Afatinib

Patient Info: Anonymized, female, 70+

Biomarkers: CD74-NRG1 fusion; no KRAS alteration detected

The cancer progressed clinically after 8 weeks on afatinib. She died in November 2021.

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Stage IV Colorectal Cancer: Albita's Patient Story

Patient Info: Albita, Female, Under 40 | Stage IV

Biomarkers: Described as wild type; no hereditary genetic marker reported

Metastatic Site: liver

Albita had Stage IV colon cancer with liver metastases. As of April 2025, the only active cancer she described was still in the liver, with 3 spots remaining after chemotherapy, radiation, liver resection, hysterectomy/colon surgery, ileostomy, and ongoing/planned liver-directed treatment.

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Rectal cancer recurring years later with perineural spread and distant metastases

Patient Info: Anonymized, Female, 50s | Stage IV

Metastatic Site: brain, lung, bone

Despite further chemotherapy, the cancer progressed to the brain, lungs and bones, and she died about 1 year later, approximately 9 years after her initial rectal-cancer treatment.

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Michelle: Stage IV Colorectal Cancer

Patient Info: Michelle, Female, 40s | Stage IV

Metastatic Site: Ovary | Femoral nerve region

As of April 2025, Michelle described living as a Stage IV colorectal cancer survivor after FOLFOX, major surgery, 2.5 years with no evidence of disease, and a later PET-detected recurrence involving the femoral nerve region.

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Stage IV Colorectal Cancer: Kasey's Patient Story

Patient Info: Kasey, Female, Under 40 | Stage IV

Biomarkers: CEA elevated; no genomic biomarker reported

Metastatic Site: liver

Kasey was diagnosed with Stage II colon cancer in February 2024 and progressed to Stage IV disease with a liver lesion in September 2024. As of April 2025, she was continuing chemotherapy after liver surgery.

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Stage III colon cancer followed by a second gastro-oesophageal adenocarcinoma

Patient Info: Anonymized, Female | Stage III

Biomarkers: KRAS-mutated, NRAS-negative, BRAF-negative

After surgery and 4 cycles of CAPEOX, imaging initially showed no metastases. Later imaging showed new bilobar liver lesions, and a separate primary gastro-oesophageal adenocarcinoma was diagnosed about 1 year after the colon cancer.

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Stage III Colorectal Adenocarcinoma: Chloe's Survivor Story

Patient Info: Chloe, Female | Stage III

Biomarkers: Familial adenomatous polyposis

As of April 2025, Chloe was in remission after emergency surgery with a stoma and 4 rounds of IV/oral chemotherapy for Stage III FAP-associated colon adenocarcinoma.

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Stage III Colorectal Cancer: Chloe's Survivor Story

Patient Info: Chloe, Female, Under 40 | Stage III

Biomarkers: Rare genetic disorder/gene reported; exact gene not stated

Chloe was diagnosed with Stage III colon cancer in February 2024 after emergency surgery. After surgery, stoma creation, and 3 months of chemotherapy, she was told she was in remission in June 2024 and remained on surveillance.

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Stage II Colorectal Cancer: Kristin's Survivor Story

Patient Info: Kristin, Female | Stage II

Kristin had Stage II colon cancer treated with emergency surgery and 4 months of chemotherapy. Her February 2022 scan confirmed no evidence of disease, and as of March 2025 she had recently celebrated 3 years cancer-free.

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Mark: Stage III Colorectal Cancer

Patient Info: Mark, Male, Under 40 | Stage III

Biomarkers: Lynch syndrome negative

As of March 2025, Mark was sharing his story after surgery and intensive chemotherapy for Stage IIIB colon cancer and had been declared to have no evidence of disease in 2021.

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Stage III Colorectal Cancer: Mark's Survivor Story

Patient Info: Mark, Male, Under 40 | Stage III

Biomarkers: Tumor genetic testing negative; Lynch syndrome not detected

Mark had Stage III right-sided colon cancer treated with surgery and chemotherapy. He has been considered no evidence of disease since finishing chemotherapy in spring 2021 and had passed the 4-year post-surgery milestone as of March 2025.

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