Metastatic triple-negative breast cancer with sacituzumab-govitecan pneumonitis and progression

Patient Info: Anonymized, Female, 60s | Stage IV

Biomarkers: ER-negative; PR-negative; HER2-negative

Metastatic Site: lung

Sacituzumab-govitecan pneumonitis improved with corticosteroids and half-dose rechallenge did not reproduce pneumonitis, but follow-up CT showed one new pulmonary metastasis and enlargement of previous lung metastases; PFS on sacituzumab govitecan was 5.37 months.

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Stage II Triple-Negative Breast Cancer: Chase's Survivor Story

Patient Info: Chase, Female, Under 40 | Stage II

Biomarkers: ER-negative; PR-negative; HER2-negative

As of January 2026, Chase had shown no evidence of cancer for nearly 5 years after Stage IIB triple-negative breast cancer treatment and had completed 3 investigational vaccine injections without significant side effects.

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Stage II Invasive Lobular Carcinoma: Tamra's Patient Story

Patient Info: Tamra, Female | Stage II

Biomarkers: MammaPrint genomic analysis pending/under consideration

As of January 2026, Tamra had chosen partial mastectomy with radiation and concurrent bilateral reconstruction for Stage II invasive lobular breast cancer, with chemotherapy decision dependent on MammaPrint results.

Lobular Breast Cancer AllianceRead more →

Stage IV HER2-Positive Breast Cancer: Sonja's Patient Story

Patient Info: Sonja Rideout, Female | Stage IV

Biomarkers: HER2-positive; Tempus testing later indicated immunotherapy as an option

Metastatic Site: Lungs; liver; bone: tailbone; thoracic lymph nodes

As of January 2026, Sonja was living with metastatic HER2-positive breast cancer after spread to lungs and liver, later tailbone and thoracic lymph nodes, and had moved to weekly carboplatin/gemcitabine plus monthly immunotherapy.

Breast cancer survivor developed Ramsay Hunt syndrome with vertigo

Patient Info: Anonymized, Female, 60s

Biomarkers: Breast cancer biomarkers not reported. Ramsay Hunt syndrome was diagnosed clinically.

Breast cancer treatment had been completed years earlier. The later neurological episode improved partially after antiviral therapy, steroids, pain control, betahistine, acupuncture, and vestibular rehabilitation, with mild residual dizziness and facial weakness at 3 months.

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Stage IV triple-negative invasive lobular breast cancer with HER2 mutations: complete metabolic response to trastuzumab deruxtecan

Patient Info: Anonymized, Female, 70+ | Stage IV

Biomarkers: Triple-negative invasive lobular breast cancer with HER2-low/dubious staining and HER2 FISH-negative; somatic ERBB2/HER2 and mutations.

Metastatic Site: iliac bone lesions / bone metastases

As of January 2026, metastatic triple-negative invasive lobular breast cancer with HER2 mutations had a sustained complete metabolic response to trastuzumab deruxtecan for 20 months, with dose reduction for neutropenia and no pulmonary toxicity.

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Breast cancer history with silicone lymphadenitis mimicking recurrence

Patient Info: Anonymized, Female, 70+

Workup of suspicious internal mammary and axillary lymph nodes found silicone-induced lymphadenitis from implant rupture, not breast cancer recurrence or metastasis.

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Stage III Breast Cancer Treatment Complicated by Coronary Thrombosis

Patient Info: Anonymized, female, 40s | Stage III

Biomarkers: ER-positive; PR-positive; HER2-negative; Ki-67 25–30%

She achieved complete remission about 12 months after the myocardial infarction and remained in complete oncologic remission at 44 months.

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Stage II HR-Positive Breast Cancer: Sian's Survivor Story

Patient Info: Sian Bevans, Female, 50s | Stage II

Biomarkers: Triple-positive

Sian was 11 years past diagnosis, completed 10 years of maintenance medication in May 2025, and reported feeling more like herself; no recurrence was described.

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Stage IV Breast Cancer: Lea's Patient Story

Patient Info: Lea, Female, Under 40 | Stage IV

Metastatic Site: Bone: hip sockets, femurs, spine; liver

As of January 2026, Lea was living with metastatic breast cancer involving bone and liver and was in active treatment with Taxol after progression changed her treatment plan.

Metastatic breast cancer history with pacing-induced cardiomyopathy and heart-function recovery

Patient Info: Anonymized, Female, 50s | Stage IV

Metastatic Site: sternum; ribs

She had osseous metastatic breast cancer involving the sternum and ribs, while pacing-induced cardiomyopathy improved clinically and biventricular function recovered completely at 6 months on medical therapy.

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Stage 3 triple-negative breast cancer complicated by immunotherapy endocrine toxicity

Patient Info: Anonymized, Female, 40s | Stage III

Biomarkers: ER-negative; PgR-negative/PR-negative; HER2 0; Ki-67 70%; triple-negative breast cancer

After neoadjuvant therapy complicated by immune-related hypothyroidism, adrenal insufficiency, and suspected hypophysitis, surgery showed residual ypT1c ypN0 triple-negative disease. Pembrolizumab was stopped, adjuvant capecitabine was completed in June 2025, and endocrine replacement/follow-up continued.

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Breast Cancer Discovered After Widespread Bone Metastases

Patient Info: Anonymized, female, 40s | Stage IV

Biomarkers: ER 90–95%; PR 90–95%; HER2 IHC 0; Ki-67 5%; germline BRCA1/2 negative

Metastatic Site: bone, bone marrow

She was receiving ongoing letrozole and ribociclib for Stage IV hormone receptor-positive, HER2-negative breast cancer with diffuse bone involvement.

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Stage 2 breast cancer: lump discovered at 61, successful treatment

Patient Info: Anonymized, Female, 60s | Stage IV

Biomarkers: Breast neuroendocrine tumor was ER/PR strongly positive, HER2 1+

Metastatic Site: lung, mediastinal lymph nodes, bone (ribs, spine,…

After Stage IIA primary breast neuroendocrine tumor treated with lumpectomy, sentinel lymph-node biopsy, radiation, and short-duration anastrozole, the patient developed metastatic recurrence about 2 years later, declined additional therapy, entered hospice, and died 1 month later.

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Left breast carcinoma with neuroendocrine differentiation: partial mastectomy and node-negative surgery

Patient Info: Anonymized, Female, 50s

Biomarkers: HER2-positive breast cancer with ER/PR-negative status and neuroendocrine markers.

Surgery was completed without perioperative complications and no recurrence or metastasis was noted before the patient was lost to follow-up; long-term status is unavailable.

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Stage I HR-Positive Invasive Lobular Carcinoma: Erica's Survivor Story

Patient Info: Erica, Female, 40s | Stage I

Biomarkers: ER-positive; PR-positive; HER2-negative

As of December 2025, Erica had Stage IA ER-positive/PR-positive/HER2-negative ILC removed with negative lymph nodes, completed 16 rounds of radiation, and was focused on survivorship and advocacy.

Lobular Breast Cancer AllianceRead more →

Triple-negative breast cancer with occult metastasis in parathyroid and ectopic thyroid adenomas: complete remission after chemotherapy

Patient Info: Anonymized, Female, 60s | Stage IV

Biomarkers: Triple-negative breast cancer. Metastatic deposits were CK7 positive and negative for ER, HER2

Metastatic Site: parathyroid adenoma; ectopic thyroid adenoma /…

As of December 2025, she remained in complete remission 1 year after systemic chemotherapy for triple-negative breast cancer with occult metastatic deposits in parathyroid and ectopic thyroid adenomas.

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Hormone receptor-positive breast cancer treated with pembrolizumab trial complicated by acquired lipodystrophy

Patient Info: Anonymized, Female, 40s

Biomarkers: HER2-negative breast cancer. Metabolic changes occurred during/after pembrolizumab.

As of December 2025, breast cancer treatment had included neoadjuvant chemotherapy/pembrolizumab, surgery, adjuvant pembrolizumab, and endocrine therapy; CT did not show recurrence during weight-loss evaluation, but she required ongoing metabolic care for pembrolizumab-associated acquired generalized lipodystrophy.

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Metastatic Breast Cancer Causing Bile Duct Obstruction and Liver Failure

Patient Info: Anonymized, female, Under 40 | Stage IV

Biomarkers: Metastatic biopsy ER-negative, PR-negative, HER2-negative

Metastatic Site: bone, liver, common bile duct

Her metastatic breast cancer progressed rapidly with diffuse liver involvement and bile-duct invasion, leading to liver failure and death 28 days after admission.

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Breast cancer history with incidental adult cystic nephroma: no renal recurrence after nephrectomy

Patient Info: Anonymized, Female, 40s

Biomarkers: Breast cancer biomarkers not reported. Kidney cystic nephroma showed PAX8 in epithelium and PR in stroma, ER absent.

As of December 2025, the kidney lesion had been resected and proven to be adult cystic nephroma rather than breast cancer metastasis, with no clinical symptoms or radiologic recurrence at 1-year follow-up.

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Young Woman With Breast Cancer and Four Inherited Cancer-Risk Variants

Patient Info: Anonymized, female, Under 40 | Stage IV

Biomarkers: ER 40%; PgR 60%; HER2 0; Ki-67 25%; germline pathogenic variants in ATM, PALB2, PMS2

Metastatic Site: brain

The breast cancer spread rapidly to the brain, and she died within a few months.

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Glycogen-rich clear cell breast carcinoma: HER2-positive early-stage case with disease-free follow-up

Patient Info: Anonymized, Female, 60s | Stage I

Biomarkers: ER-positive; HER2-positive; PR-negative; Ki-67 ~10%; intracytoplasmic glycogen confirmed

At 1-year follow-up, she had no evidence of breast cancer recurrence.

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Luminal B-like lobular breast cancer: robotic-assisted nipple-sparing mastectomy with 12-month disease-free follow-up

Patient Info: Anonymized, Female, 40s

Biomarkers: ER 90%; PR 100%; HER2-negative; Ki-67 20%; luminal B-like subtype

As of November 2025, she was disease-free 12 months after neoadjuvant taxane-based chemotherapy and single-port robotic-assisted nipple-sparing mastectomy with immediate reconstruction.

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Stage IV ER/PR-positive breast cancer with retinal vein and artery occlusion during endocrine-targeted therapy

Patient Info: Anonymized, Female, 50s | Stage IV

Biomarkers: ER 70%; PR 100%; HER2-negative; Ki-67 10%

Metastatic Site: bone (cranial vault, right first rib, sternum, D5, D6,…

As of November 2025, she continued care for Stage IV ER/PR-positive breast cancer with bone metastases while also managing severe left-eye retinal vascular occlusion and limited visual recovery.

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