Hormone Therapy for PR Positive Breast Cancer: 85 Real Stories

HER2-positive Stage IIB breast cancer complicated by acute neuro-Behcet disease during neoadjuvant treatment

Patient Info: Anonymized, Female, 40s | Stage II

Biomarkers: ER-positive; PgR/PR-positive; HER2-positive by FISH amplification; Ki-67 index 50%

As of June 2024, there was no recurrence of breast cancer or neuro-Behcet disease 2 years after surgery and postoperative HER2-directed plus endocrine therapy.

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Male breast cancer in both breasts linked to Klinefelter syndrome, initially missed

Patient Info: Anonymized, Male | Stage IV

Biomarkers: ER-positive; PR-positive; HER2-negative; Klinefelter syndrome

Metastatic Site: spine / bone

With advanced metastatic disease and an estimated prognosis of weeks or less, care focused on symptom relief under the palliative-care team.

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Triple-Negative Breast Cancer: Susan's Patient Story

Patient Info: Susan, Female, 70+

Biomarkers: BRCA negative; earlier breast cancer described as triple-negative; later breast cancer estrogen-positive and progesterone-positive; HER2 not reported

As of August 2023, Susan was living after multiple breast cancer diagnoses, including a later estrogen-positive/progesterone-positive non-metastatic breast cancer treated with bilateral mastectomy and ongoing 5-year estrogen-blocker therapy.

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Stage II HR-Positive Invasive Lobular Carcinoma: Megan's Survivor Story

Patient Info: Megan Claire Chase, Female | Stage II

Biomarkers: ER-positive; PR-positive; HER2 not reported

As of July 2023, Megan-Claire was in survivorship after Stage II invasive lobular breast cancer, with clear early scans but significant long-term effects, surgical menopause, chronic pain, fatigue, chemo brain, and inability to tolerate recurrence-prevention medications.

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Stage III HR-Positive Breast Cancer: Sarah's Survivor Story

Patient Info: Sarah McDonald, Female, 40s | Stage III

Biomarkers: ER-positive; PR-positive; HER2-negative

Sarah was 10 years from diagnosis without a recurrence and described the breast cancer as successfully treated. She later paused hormone therapy, completed IVF and gave birth at age 48.

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Stage IV HR-Positive Breast Cancer: Abigail's Patient Story

Patient Info: Abigail Myers, female, Under 40 | Stage IV

Biomarkers: ER-positive, PR-positive, HER2-positive

Metastatic Site: bones, brain

Abigail continued living with Stage IV metastatic breast cancer after about 8 years of multiple treatment lines, including therapy for bone and brain metastases.

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Chemotherapy complication: methotrexate absorbed into the bloodstream after spinal injection

Patient Info: Anonymized, Female | Stage IV

Biomarkers: ER-positive; PR-positive; HER2-negative; Oncotype DX Recurrence Score 20

Metastatic Site: leptomeninges / central nervous system; brain

Five months after leptomeningeal carcinomatosis was recognised, she developed a new 2 cm brain lesion and neurological decline. Her family chose supportive care, and she died 10 days after transfer to inpatient hospice.

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Breast cancer that spread to the thymus gland

Patient Info: Anonymized, Female | Stage IV

Biomarkers: Oestrogen receptor-positive; progesterone receptor-positive; HER2-negative

Metastatic Site: thymus

She had a good response after 4 cycles of abemaciclib, anastrozole and goserelin and continued endocrine treatment with surveillance of the opposite breast.

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HR-Positive Invasive Ductal Carcinoma: Annette's Patient Story

Patient Info: Annette La Fontaine, Female

Biomarkers: ER-positive; PR-positive; HER2-negative

As of January 2023, Annette was in survivorship after bilateral mastectomy and reconstruction and was taking a daily aromatase inhibitor to reduce recurrence risk while rebuilding body confidence and emotional well-being.

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Recurrent Lobular Breast Cancer Spread to the Opposite Armpit Lymph Node

Patient Info: Anonymized, Female, 60s | Stage IV

Biomarkers: ER-positive; PR-positive; HER2-negative

Metastatic Site: Contralateral right axillary lymph node

After surgery for the recurrence and removal of the opposite-side axillary nodes, the patient proceeded with adjuvant chemotherapy and remained in active treatment.

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Male breast cancer discovered after years of stiff-person syndrome

Patient Info: Anonymized, Male, 50s

Biomarkers: ER-positive; PR-positive; HER2-negative; anti-amphiphysin antibody positive at 1:64; hereditary cancer panel negative for pathogenic germline variants.

He completed curative-intent breast cancer treatment and reported substantial improvement in upper-body stiffness, although lower-extremity stiffness, cramps, and unsteadiness persisted.

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Breast cancer with sarcoidosis that mimicked metastatic disease

Patient Info: Anonymized, Female, 40s

Biomarkers: ER-positive; PR-positive; HER2-negative.

Her most recent mammogram showed no recurrent breast cancer while she continued letrozole, goserelin, and six-monthly follow-up.

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Breast cancer recurrence in the mandibular condyle causing jaw pain

Patient Info: Anonymized, Female, 50s | Stage IV

Biomarkers: ER-positive; PR-positive; HER2-negative.

Metastatic Site: right mandibular condyle with extension into the…

After anastrozole and 60 Gy of radiation, her jaw pain, mouth opening, and function improved, although some discomfort remained and palliative systemic treatment was continuing.

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Locally advanced male breast cancer associated with a pathogenic ATM variant

Patient Info: Anonymized, Male, 50s | Stage Metastatic/Advanced

Biomarkers: ER 100% positive; PR 100% positive; HER2-negative; Ki-67 30%; germline pathogenic ATM variant c.2921+1G>A.

Two years after diagnosis, he had an ECOG performance status of 0 and remained without signs of breast-cancer relapse or another primary cancer.

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Breast Cancer Recurrence Treated With Radiation Despite a Chronic Skin Condition

Patient Info: Anonymized, Female, 50s

Biomarkers: ER-positive; PR-positive; HER2-negative

After treatment of a chest-wall recurrence and a radiographically suspicious ischial lesion, she completed chest-wall radiation, her skin healed within 5 weeks, and she remained under surgical, radiation-oncology, and dermatology review.

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Male breast cancer found after persistent nipple discharge without a lump

Patient Info: Anonymized, Male, 60s | Stage 0

Biomarkers: ER-positive; PR-positive

Six months after mastectomy, surveillance examination found no clinical evidence of recurrence.

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A New Breast Cancer Arising Beneath an Accessory Nipple

Patient Info: Anonymized, Female, 40s

Biomarkers: ER 5%; PR 5–10%; HER2-negative.

After chemotherapy, surgery, endocrine therapy, proton radiation, and later reconstruction revision, she was currently without evidence of disease.

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Lobular breast cancer later spread to the stomach, bone, neck and mediastinum

Patient Info: Anonymized, Female, 70+ | Stage IV

Biomarkers: ER-positive; PR-positive; HER2-negative

Metastatic Site: stomach|bone|neck|mediastinum

After gastric metastasis was diagnosed and later imaging showed bone, neck and mediastinal spread, her oral intake and health declined; she chose palliative care and died 7 months after the diagnostic endoscopy.

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Stage II HR-Positive Invasive Ductal Carcinoma: Caitlin's Patient Story

Patient Info: Caitlin J., Female, Under 40 | Stage II

Biomarkers: ER-positive; PR-positive; BRCA-negative

As of July 2020, Caitlin had completed lumpectomy, AC chemotherapy, Taxol, and 33 radiation treatments for Stage IIB ER-positive, PR-positive IDC and was continuing monthly Lupron plus daily anastrozole.

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Lobular Breast Cancer Spread Into a Nasal Tumor

Patient Info: Anonymized, Female, 60s | Stage IV

Biomarkers: Metastatic lobular focus: ER 8/8; PR 8/8; HER2-negative; E-cadherin-negative.

Metastatic Site: liver; bone; right nasal cavity within an olfactory…

The nasal lesion was removed with no residual local disease on imaging, and capecitabine was restarted while oncology follow-up continued for metastatic breast cancer.

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Stage IV Breast Cancer: Kirby's Patient Story

Patient Info: Kirby Lewis, Male | Stage IV

Biomarkers: ER-positive, PR-positive, HER2-negative

Metastatic Site: lung|spine

Kirby was living with metastatic breast cancer, and his most recent scans showed the right-lung tumor was stable with no signs of progression while he continued fulvestrant and palbociclib.

A second breast cancer arising in a previously known cyst

Patient Info: Anonymized, Female, 70+

Biomarkers: ER >95% positive; PR >95% positive; HER2 negative; Ki-67 11–50%; p53 negative for overexpression

She completed right-breast radiation and was continuing anastrozole 1 mg daily as adjuvant endocrine therapy.

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Early breast cancer followed 19 years later by a radiation-related breast sarcoma

Patient Info: Anonymized, Female, 70+ | Stage I

Biomarkers: Strongly ER-positive; strongly PR-positive.

The stage IA breast carcinoma remained disease-free for 19 years; a later right-breast mass was a separate radiation-induced sarcoma rather than recurrent carcinoma.

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Metastatic Breast Cancer Presenting With Severe Pulmonary Hypertension

Patient Info: Anonymized, Female, Under 40 | Stage IV

Biomarkers: ER-positive; PR-positive.

Metastatic Site: bone; bone marrow

At seven months, she was doing well with a marked response on PET imaging, normalized right-heart pressures, and ongoing systemic treatment with palbociclib.

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