Stage III Invasive Ductal Carcinoma: Vanessa's Survivor Story

Patient Info: Vanessa Sanders, Female, Under 40 | Stage III

As of November 2019, Vanessa had shown no evidence of disease for 15 years after clinical-trial chemotherapy, breast-conserving surgery and 6 weeks of radiation for Stage III invasive ductal breast cancer.

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Breast cancer spreading to the colon, rectum and peritoneal surfaces

Patient Info: Anonymized, Female, 60s | Stage IV

Biomarkers: Primary tumor: ER >80% positive; PR 50–60% positive; HER2 negative; E-cadherin positive. Later colorectal metastases: ER positive; PR negative; HER2 negative; CK7 positive; CK20 negative; CDX2 negative.

Metastatic Site: colon, rectum, peritoneum, diaphragm, liver, bowel,…

Metastatic breast cancer was subsequently confirmed in the colon and rectum, with later laparoscopic biopsies showing peritoneal and additional intra-abdominal metastatic disease.

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Metastatic Breast Cancer With Durable Liver and Peritoneal Response to Eribulin

Patient Info: Anonymized, female, 50s | Stage IV

Biomarkers: Initial tumor: ER 90%, PgR 70%. Liver metastasis: ER 60%, HER2 1+

Metastatic Site: liver, peritoneum

While continuing eribulin beyond 34 cycles, her liver disease was stable and the peritoneal response persisted after earlier major tumor reduction.

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Metastatic Breast Cancer With Liver Progression Treated Through Multiple Chemotherapy Lines

Patient Info: Anonymized, female, 40s | Stage IV

Biomarkers: Initial tumor: ER 90%, HER2 3+, Ki67 15%. Liver metastasis: ER 30%

Metastatic Site: pleura, liver

After several periods of response and later liver progression, she remained on active treatment with pegylated liposomal doxorubicin.

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Metastatic Breast Cancer With Bone and Liver Progression After Multiple Therapies

Patient Info: Anonymized, female, Under 40 | Stage IV

Biomarkers: Initial tumor: ER 80%, HER2 negative, Ki67 18%. Liver metastasis: ER 75%

Metastatic Site: bone, liver

After massive hepatic progression and liver failure, chemotherapy was stopped and she died on January 31, 2016.

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Stage IV Breast Cancer: Debora's Patient Story

Patient Info: Debora, Female, 60s | Stage IV

Debora was living with metastatic breast cancer after Stage III disease treated with surgery, chemotherapy, radiation therapy, and targeted therapy; four years after surgery, she was told the cancer had metastasized and was on targeted therapy.

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Male Breast Cancer Treatment Complicated by Stevens-Johnson Syndrome

Patient Info: Anonymized, male, 60s

After the third chemotherapy cycle he developed severe Stevens-Johnson syndrome with disseminated intravascular coagulation and multiorgan failure, and he died after care was shifted to comfort measures.

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Stage III Inflammatory Breast Cancer Diagnosed After Severe Breast Pain and Swelling Following Mammography

Patient Info: Anonymized, female, 60s | Stage IV

Biomarkers: ER negative, PR negative, HER2 highly positive

After later metastatic disease was found, she chose no further active treatment and died of progressive disease in 2012.

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Mixed epithelial and mesenchymal metaplastic breast carcinoma: no recurrence 1 year after surgery and adjuvant therapy

Patient Info: Anonymized, Female, 40s

Biomarkers: Mixed metaplastic breast cancer: epithelial part ER/PR/HER2-positive; mesenchymal part ER/PR-negative with weak HER2. Ki-67 ~20%.

As of March 2014, she was doing well with no recurrence or metastasis 1 year after modified radical mastectomy, adjuvant CEF/Taxotere chemotherapy, and tamoxifen.

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Breast invasive ductal carcinoma with coexisting inflammatory myofibroblastic tumor: disease-free after mastectomy, TAC, and tamoxifen

Patient Info: Anonymized, Female, Under 40

Biomarkers: Breast cancer: ER/PR-positive with HER2 2+ and p53-positive. Separate inflammatory myofibroblastic tumor had ALK/vimentin/actin/S-100 markers.

As of August 2013, she remained disease-free 2 years after modified radical mastectomy, 6 courses of TAC chemotherapy, and tamoxifen.

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Triple-negative glycogen-rich clear cell carcinoma of the breast: chemotherapy, mastectomy, and radiation

Patient Info: Anonymized, Female, 50s | Stage III

Biomarkers: Triple-negative breast cancer with glycogen-rich clear cell features; pathology stains supported breast carcinoma.

Asymptomatic and disease-free 14 months after surgery, additional chemotherapy, and 50 Gy radiotherapy for T4N0M0 triple-negative glycogen-rich clear cell breast carcinoma.

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ER-positive breast cancer recurrence after DCIS: chemotherapy, nodal surgery, radiation, and endocrine therapy

Patient Info: Anonymized, Female, 40s

Biomarkers: Recurrent invasive breast cancer: ER-positive; HER2/neu-negative. PR not reported.

Disease-free for 33 months after treatment of ER-positive, HER2-negative invasive breast cancer recurring in the mastectomy skin flap with positive axillary sentinel nodes.

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