Stage IV KRAS Colorectal Cancer: Lauren's Patient Story

Patient Info: Lauren Bimage, Female, Under 40 | Stage IV

Biomarkers: Patient-reported KRAS-mutated colon cancer

Metastatic Site: chest; abdominal/peritoneal lining; spine/back

As of September 2024, Lauren was living with both Stage IV breast cancer and Stage IV colon cancer. Colon cancer markers were described as low/normal, while biopsy showed the persistent back/spine disease was breast cancer.

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Stage III squamous lung cancer controlled during treatment while a second pancreatic cancer developed

Patient Info: Anonymized, female, 50s | Stage III

Biomarkers: KRAS exon 2 mutation

She died in March 2022. Her Stage III lung cancer had remained controlled for about 18 months, while a separate pancreatic cancer developed and progressed.

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Regorafenib produced a radiologic complete response in metastatic colon cancer with lung metastases

Patient Info: Anonymized, male, 60s | Stage IV

Biomarkers: KRAS codon 146 mutation; BRAF wild type; MSI-low

Metastatic Site: liver, lung

Nine months after stopping regorafenib, CT showed scarring of the lung metastases consistent with a radiologic complete response.

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Rare lung cancer first discovered as a mass in the skull

Patient Info: Anonymized, Male | Stage IV

Biomarkers: KRAS ; CK7-positive; CDX2-positive; pathology favoured pulmonary enteric adenocarcinoma

Metastatic Site: skull base / sphenoid sinus; right posterior acetabulum

He received palliative radiation and prolonged systemic therapy, completing 35 cycles including 31 maintenance cycles of pemetrexed and pembrolizumab.

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Lung cancer in a young adult mistaken for recurring pneumonia

Patient Info: Anonymized, Male | Stage III

Biomarkers: KRAS mutation

Two months after discharge, he began carboplatin, pemetrexed and pembrolizumab and had received 2 cycles.

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Stage IV KRAS Colorectal Cancer: Kris's Patient Story

Patient Info: Kris Sokolowski, Male, 40s | Stage IV

Biomarkers: KRAS mutation

Metastatic Site: Liver; sternum; spine; lymph nodes; omentum/abdominal…

As of May 2022, Kris was living with Stage IV KRAS G13D-mutant colorectal cancer. Most tumors had been stable or shrinking, but abdominal/omental disease continued to grow despite additional full-strength chemotherapy, so clinical-trial and immunotherapy options were being explored.

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Stage III KRAS Non-Small Cell Lung Cancer: Terri's Survivor Story

Patient Info: Terri Conneran, Female | Stage III

Biomarkers: KRAS-mutated; PD-L1 level reviewed/tested

As of March 2021, Terri had Stage IIIA KRAS-mutated NSCLC with 3 local recurrences treated over time and had again reached no evidence of disease while continuing close surveillance and advocacy through KRAS Kickers.

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Severe immune thrombocytopenia during treatment for metastatic colon cancer

Patient Info: Anonymized, Female, 50s | Stage IV

Biomarkers: KRAS-mutated; microsatellite stable; BRAF-wild type.

Metastatic Site: bilateral ovaries; pelvis; peritoneum; mesenteric…

After multiple metastatic recurrences and treatment changes, she died from progressive colon cancer; oxaliplatin had been permanently stopped after antibody-confirmed immune thrombocytopenia.

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Metastatic Right-Sided Colon Cancer With an NRG1 Fusion

Patient Info: Anonymized, Male, 60s | Stage IV

Biomarkers: KRAS mutation; POMK-NRG1 fusion

Metastatic Site: liver|lungs

He had persistent metastatic disease after 16 months of afatinib and entered a phase I trial in January 2020.

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Treatment-Related Inflammation Mimicked Metastatic Colon Cancer Recurrence

Patient Info: Anonymized, Male, 50s | Stage IV

Biomarkers: KRAS mutation

Metastatic Site: liver|peritoneum

Biopsy showed that new lymph-node, liver, and spleen findings were a treatment-related sarcoid-like reaction rather than recurrence, and 18 months of surveillance found no evidence of cancer.

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Colon Cancer Metastasis Found Inside a Thyroid Nodule

Patient Info: Anonymized, Male, 50s | Stage Metastatic/Advanced

Biomarkers: KRAS mutated; thyroid metastasis CDX2 positive and CK20 positive; PAX8/TG/TTF-1 negative

Metastatic Site: lungs|thyroid

Follow-up was planned after thyroid surgery, with no adjuvant treatment for the coexisting low-risk thyroid lesion.

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Metastatic Colon Cancer With KRAS, NRAS, and BRAF Mutations

Patient Info: Anonymized, Male, 60s | Stage IV

Biomarkers: KRAS exon 3 ; NRAS exon 2 ; BRAF exon 10 ; PIK3CA exon 2 .

Metastatic Site: liver

The liver metastases progressed despite FOLFOX and bevacizumab, and he died within one year of the initial diagnosis.

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Metastatic Colon Cancer With Painful Skin Fissures During Cetuximab

Patient Info: Anonymized, Male, 60s | Stage IV

Biomarkers: KRAS unmutated

Metastatic Site: lungs|pericardium|mediastinal lymph nodes

He died not long after cetuximab was stopped following cancer progression.

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Malignant Struma Ovarii With Papillary Thyroid-Type Cancer

Patient Info: Anonymized, female, 40s

Biomarkers: KRAS mutation

Radioactive iodine scans showed no local or distant disease, and she was well and symptom-free 12 months after the initial diagnosis while continuing follow-up.

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Large cell lung carcinoma with solitary jejunal metastasis: no evidence of disease 4 years after treatment

Patient Info: Anonymized, Female, 60s | Stage IV

Biomarkers: Primary lung tumor and jejunal metastasis shared a KRAS codon 61 mutation; staining supported lung origin.

Metastatic Site: jejunum

As of January 2010, she was doing well with no evidence of disease 4 years after diagnosis and treatment of a solitary jejunal metastasis from large cell lung carcinoma.

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