Male Breast Cancer Controlled for Years Through Multiple Lines of Targeted and Endocrine Therapy

Patient Info: Anonymized, male, 70+ | Stage IV

Biomarkers: Initial tumor ER-positive, PR-positive, HER2-positive; later ER-positive, PR-negative, HER2-negative; PIK3CA mutation; germline BRCA1/2 negative

Metastatic Site: bones, pleura, liver

After a 5-year and 6-month disease-free interval, the cancer recurred in bone and later progressed to the pleura and liver. He died in January 2021, more than 13 years after his 2007 breast-cancer diagnosis.

PubMed CentralRead more →

Treatment-Refractory Triple-Negative Breast Cancer Treated With Tumor-Infiltrating Lymphocytes

Patient Info: Anonymized, female, Under 40 | Stage IV

Biomarkers: Germline BRCA1 pathogenic variant; later triple-negative phenotype

Metastatic Site: skin, lungs, bones

Tumor burden briefly decreased after tumor-infiltrating lymphocyte therapy, but she developed severe treatment complications followed by rapid cancer relapse and died about 1 month after the TIL/IL-2 treatment began.

PubMed CentralRead more →

Stage IV ALK Lung Cancer: Matt's Survivor Story

Patient Info: Matt Hiznay, Male, Under 40 | Stage IV

Biomarkers: ALK mutation / ALK-positive

Metastatic Site: Not reported

As of November 2023, Matt was a 12-year survivor with Stage IV ALK-positive lung cancer in remission, no evidence of disease, and ongoing lorlatinib treatment.

Cleveland ClinicRead more →

Brain radiation therapy complication (radionecrosis) potentially linked to combined chemo-immunotherapy

Patient Info: Anonymized, Female | Stage IV

Biomarkers: PD-L1 0%; tumour mutational burden 33 mutations/Mb; TP53 mutation at diagnosis; later ctDNA included KEAP1 and NOTCH3 alterations

Metastatic Site: brain; presumed leptomeningeal disease

She recovered completely from surgery for radiation necrosis, resumed cancer treatment and remained neurologically intact at 18 months. She was found deceased 9 months later; the cause of death was unknown.

PubMed CentralRead more →

Metastatic Breast Cancer Treatment Complicated by a Supplement–Drug Interaction

Patient Info: Anonymized, female, 50s | Stage IV

Biomarkers: ER-positive, PR-positive, HER2-negative

Metastatic Site: bones

She resumed ribociclib with letrozole after the supplement was discontinued and the treatment-related neutropenia improved enough to restart therapy.

PubMed CentralRead more →

Breast Cancer Patient Avoids a Potential Supplement Interaction During Paclitaxel Treatment

Patient Info: Anonymized, female, 50s

Biomarkers: ER-positive, PR-positive

She continued cancer treatment with trastuzumab after completing the documented paclitaxel portion of therapy.

PubMed CentralRead more →

Stage IV Breast Cancer: Sherri's Patient Story

Patient Info: Sherri, Female | Stage IV

Biomarkers: BRCA1-negative

Metastatic Site: Bone marrow

As of November 2023, Sherri had no evidence of disease on recent breast cancer scans but remained on targeted treatment every 3 weeks and had started oxaliplatin after surgery for a separate Stage III colon cancer.

The Patient StoryRead more →

Stage IV HER2-Positive Multiple primaries: metastatic Breast Cancer + Colon/Colorectal Cancer: Sherri's Patient Story

Patient Info: Sherri, Female | Stage IV

Biomarkers: HER2-positive breast cancer; colon cancer Signatera positive before surgery and negative after surgery

Metastatic Site: Bone marrow

As of October 2023, Sherri had no evidence of disease on recent scans for HER2-positive metastatic breast cancer but was receiving oxaliplatin/Oxyplatin chemotherapy and transfusions for a separate early Stage III colon cancer.

The Patient StoryRead more →

Stage IV Inflammatory Breast Cancer: Corky's Patient Story

Patient Info: Corky, Female, 60s | Stage IV

Metastatic Site: Not reported

As of October 2023, Corky was living with Stage IV inflammatory breast cancer as a chronic condition, receiving ongoing treatment focused on prolonging life and preserving quality of life.

Cleveland ClinicRead more →

Metastatic breast cancer: three years in remission with T-DM1 (Kadcyla) treatment

Patient Info: Anonymized, Female | Stage IV

Biomarkers: HER2-positive; hormone receptor-positive

Metastatic Site: liver; spine / bone

T-DM1 produced a complete clinical and radiological response after 7 cycles, sustained for 41 months and 60 cycles while treatment continued.

PubMed CentralRead more →

Stage IV ALK Non-Small Cell Lung Cancer: Christine's Patient Story

Patient Info: Christine, Female, 50s | Stage IV

Biomarkers: ALK mutation / ALK-positive

Metastatic Site: Brain | Liver

As of October 2023, Christine was living with Stage IV ALK-positive NSCLC that remained in check on targeted therapy after alectinib cleared brain and liver spots and lorlatinib continued, with significant chronic side effects.

Lung Cancer Research FoundationRead more →

Breast cancer lung metastasis treated with a minimally invasive freezing procedure

Patient Info: Anonymized, Female | Stage IV

Biomarkers: HER2-positive; ER-negative

Metastatic Site: lungs

Follow-up PET/CT at 3, 6, 9 and 12 months after cryoablation showed no progression or new lesions without systemic therapy.

PubMed CentralRead more →

Invasive Lobular Carcinoma: Brenda's Survivor Story

Patient Info: Brenda, Female, 40s

Brenda completed mastectomy, chemotherapy, radiation and an oophorectomy. She remained on anastrozole and a CDK4/6 inhibitor when she shared her story.

Lobular Breast Cancer AllianceRead more →

Stage IV HER2-Positive Inflammatory Breast Cancer: Olivia's Survivor Story

Patient Info: Olivia Franz, Female, Under 40 | Stage IV

Biomarkers: HER2-positive

Metastatic Site: Bones; distant lymph nodes

As of October 2023, Olivia continued to show no evidence of disease on scans while receiving maintenance trastuzumab and pertuzumab every 3 weeks and zoledronic acid every 3 months for bone health.

MD AndersonRead more →

Exercise Trainer Helps Detect Brain Metastases in a Woman With Long-Standing Metastatic Breast Cancer

Patient Info: Anonymized, female, 70+ | Stage IV

Biomarkers: ER-positive, PR-negative, HER2-negative

Metastatic Site: liver, bones, lymph nodes, kidney, brain

She died 5 months after the brain metastases were diagnosed, roughly 7 years after her original 2014 breast-cancer diagnosis.

PubMed CentralRead more →

BRCA2-Mutated Metastatic Lung Adenocarcinoma Controlled for 30 Months With Olaparib

Patient Info: Anonymized, female, 60s | Stage IV

Biomarkers: PD-L1-negative; BRCA2 mutation; ATM mutation; EGFR-negative; ALK-negative

Metastatic Site: brain

Olaparib provided about 30 months of disease control, and PET imaging remained overall stable when a separate new breast primary was found in February 2023.

PubMed CentralRead more →

Stage IV Colorectal Cancer: Keith's Patient Story

Patient Info: Keith, Male, 40s | Stage IV

Metastatic Site: Liver; lymph nodes; lungs

As of September 2023, Keith was on third-line treatment for Stage IV colon cancer with lung metastases, small lung lesions under 1 cm, a low tumor marker after 2 rounds, and possible trial/transplant options after standard care.

The Patient StoryRead more →

Stage IV Triple-Negative Breast Cancer: April's Patient Story

Patient Info: April Donaldson, Female, 40s | Stage IV

Biomarkers: Triple-negative breast cancer; BRCA1 positive

Metastatic Site: Lungs

As of September 2023, April was living with Stage IV metastatic triple-negative breast cancer in the lungs; scans were stable in February but showed growth again in July, and PARP inhibitor therapy was being planned.

The Patient StoryRead more →

Stage IV HER2-Positive Colorectal Cancer: Brian's Patient Story

Patient Info: Brian Beck, 50s | Stage IV

Biomarkers: HER2-positive

Metastatic Site: liver

Brian was receiving tucatinib plus trastuzumab on a clinical trial and was working full time 4.5 years after his Stage IV diagnosis.

Stage III Ovarian Cancer: Jaclyn's Patient Story

Patient Info: Jaclyn (Jackie) VanRaaphorst | Stage III

Biomarkers: FRα-positive; CA-125 monitored

AACR later reported that Jackie died on January 16, 2025.

Stage IV Breast Cancer: Britney's Patient Story

Patient Info: Britney Beadle, Female, Under 40 | Stage IV

Metastatic Site: Bone; liver; brain; lungs

As of August 2023, Britney was living with Stage IV breast cancer on Enhertu every 21 days, with liver clear and bone/lung disease showing regression on the latest described scan.

The Patient StoryRead more →

Stage IV Breast Cancer: Brittney's Patient Story

Patient Info: Brittney Beadle, Female, Under 40 | Stage IV

Metastatic Site: Bones; liver; brain; lungs

As of August 2023, Brittney was living with Stage IV breast cancer on ENHERTU every 21 days, with brain clear for 4.5 years, liver clear, and bone and lung disease regressing.

The Patient StoryRead more →

Painful eye metastasis from Stage IV gastric cancer

Patient Info: Anonymized, male | Stage IV

Metastatic Site: bone, choroid of left eye

The eye surgery relieved his pain, but he died 2 months later.

PubMed CentralRead more →

HER2-Positive Acantholytic Squamous Breast Cancer Responds Completely to Preoperative Therapy

Patient Info: Anonymized, female

Biomarkers: HER2-positive; postoperative residual in-situ disease ER-positive and PR-positive

The invasive cancer achieved a pathologic complete response, and she had no recurrence or metastasis during 1.5 years of follow-up.

PubMed CentralRead more →