Stage II central breast cancer: oncoplastic breast-conserving surgery with hatchet and AICAP flaps

Patient Info: Anonymized, Female, 70+ | Stage II

She completed oncoplastic breast-conserving surgery and radiotherapy; 3 months after radiotherapy, the reconstructed breast remained soft with sufficient volume and favorable cosmetic results.

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Stage IIA breast collision tumor: disease-free after surgery and adjuvant therapy

Patient Info: Anonymized, Female, 70+ | Stage II

Biomarkers: Two breast tumor parts were ER-positive; one HER2-low/negative and one HER2-positive. BRCA testing was suggested but not done.

Four years after surgery, she remained disease-free after mastectomy, adjuvant chemotherapy, HER2-targeted therapy, and endocrine therapy.

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Luminal A solid papillary breast carcinoma with lung metastasis: mastectomy and lung resection, PET-CT clear

Patient Info: Anonymized, Female, 50s | Stage IV

Biomarkers: Initial breast tumor and lung metastasis were ER/PR positive, HER2 0

Metastatic Site: lung

About 40 days after lung surgery, PET-CT showed no abnormalities; the specialist recommended regular follow-up without additional antitumor drug therapy, and she was alive and in good condition.

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Stage IV Ovarian Cancer: Evelyn's Survivor Story

Patient Info: Evelyn, female | Stage IV

Biomarkers: HRD-positive

After chemotherapy and surgery, Evelyn reported an unremarkable final scan in May 2023 and then completed 2 years of Lynparza maintenance therapy guided by HRD-positive tumor testing.

The Cancer Spread One Year Later…

Patient Info: Kalei, Female, Under 40 | Stage IV

Metastatic Site: Lungs; bilateral lung nodules

Kalei initially had Stage II rectal cancer that responded to chemoradiation and IV chemotherapy without rectal surgery. In 2025, biopsy-proven lung metastasis changed the diagnosis to Stage IV. As of October 2025, she had undergone lung resections with clear margins and remained in ongoing follow-up rather than having a clearly stated NED status.

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Breast Cancer: Theresa's Survivor Story

Patient Info: Theresa, Female, 40s

Biomarkers: Hormone receptor-positive; exact receptors not fully specified

Theresa completed treatment for multiple cancers, including bilateral mastectomy/reconstruction for breast cancer and later excision plus 3 months of radiation for chest-wall recurrence. As of October 2025, she described being about 6 years out from the later recurrence, with no other cancer found on scans.

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Hormone receptor-positive male breast cancer: spontaneous regression after biopsy and mastectomy

Patient Info: Anonymized, Male, 50s

Biomarkers: ER-positive; PR-positive; HER2-negative; p63 staining confirmed myoepithelial cells in residual benign cystic lesion

Mastectomy and axillary clearance showed no residual invasive carcinoma or carcinoma in situ, with clear margins; he recovered well and began adjuvant tamoxifen because of the original ER/PR-positive biopsy.

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KRAS G12C lung adenocarcinoma with hypertrophic pulmonary osteoarthropathy: no recurrence after lobectomy

Patient Info: Anonymized, Male, 50s | Stage II

Biomarkers: KRAS detected; PD-L1 <1%

At 1-year follow-up, there was no evidence of recurrence; pain, edema, grip strength, and periosteal thickening related to hypertrophic pulmonary osteoarthropathy improved after surgery.

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Early Stomach Cancer Removed Endoscopically With No Recurrence 8 Years Later

Patient Info: Anonymized, Male, 70+

Eight years after endoscopic treatment for early gastric cancer, upper and lower endoscopy, imaging, and tumor-marker testing showed no evidence of recurrence or another malignancy.

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Early Papillary Stomach Cancer Found During Evaluation of Kidney Disease

Patient Info: Anonymized, Male, 70+

Biomarkers: THSD7A positive in intestinal-type adenocarcinoma; MUC2 positive; CDX2 positive

The gastric tumor was completely removed by distal gastrectomy, and the associated nephrotic syndrome improved within 3 months without immunosuppressive treatment.

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Breast Cancer: Karin's Patient Story

Patient Info: Karin, Female, 50s

As of September 2025, Karin was living with recurrent incurable breast cancer, felt healthy and fit, and had chosen mastectomy with reconstruction, ovary removal, anti-hormone therapy, and complementary therapies after recurrence.

PT3N0 triple-negative breast carcinosarcoma: surgery, EC chemotherapy, radiation, disease-free at 26 months

Patient Info: Anonymized, Female, 50s

Biomarkers: Triple-negative breast carcinosarcoma. INI1 was retained

She was clinically free of disease at her last follow-up in April 2025, 26 months after treatment completion; December 2024 mammography showed no suspicious changes.

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Stage IV sigmoid colon cancer: recurrence after FOLFOX, hepatectomy, and colectomy

Patient Info: Anonymized, Male, 60s | Stage IV

Biomarkers: Mismatch repair proficient; microsatellite stable; KRAS wild-type; BRAF wild-type; CEA 3.8 ng/mL at diagnosis

Metastatic Site: liver, lung

As of September 2025, metastatic sigmoid colon cancer had recurred in the lungs and remnant liver after initial FOLFOX, hepatectomy, and colectomy, requiring FOLFIRI plus cetuximab.

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Paget disease, bilateral apocrine breast carcinomas, and primary breast follicular lymphoma after aromatase inhibition

Patient Info: Anonymized, Female, 70+

Biomarkers: Initial breast cancer was ER/PR-positive, HER2-negative. Later apocrine cancers were triple-negative with AR/ER-beta markers. Lymphoma had IgH::BCL2.

As of September 2025, she was alive 3 years after bilateral mastectomy and observation for Stage Ie follicular lymphoma, with no recurrence of either breast carcinoma or lymphoma.

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Aggressive SMARCA4-deficient gastric cancer with rapid liver metastases after surgery

Patient Info: Anonymized, Female, 70+ | Stage IV

Biomarkers: SMARCA4 loss; SMARCA4 frameshift mutation

Metastatic Site: liver

Multiple liver metastases appeared within 1 week after surgery. She received 1 chemotherapy cycle but could not continue because of poor condition and was transferred for hospice care.

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Rare Ovarian Neuroendocrine Cancer Treated With Surgery and Chemotherapy

Patient Info: Anonymized, female, 40s

Biomarkers: somatic BRCA2 mutation; MSI-H; high tumor mutational burden; germline BRCA2 negative

CT imaging and CA-125 follow-up showed no evidence of recurrence over 2 years.

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SMARCA4-deficient gastric cancer treated with surgery and adjuvant chemotherapy

Patient Info: Anonymized, Male, 70+

Biomarkers: SMARCA4 loss

After surgery and 5 cycles of adjuvant XELOX, he remained under surveillance without recurrence at the latest follow-up.

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Stage 0 ER-positive DCIS: mastectomy without adjuvant therapy, followed by successful pregnancy

Patient Info: Anonymized, Female, 40s | Stage 0

Biomarkers: ER-positive; PgR-positive; HER2-negative; nuclear grade 2; comedo type; negative margins; no lymph node involvement

She completed surgical treatment for Stage 0 DCIS with negative margins and no lymph node involvement, avoided adjuvant therapy, resumed assisted reproductive treatment, and delivered a healthy male infant.

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HER2-positive invasive lobular breast cancer in a transgender man: disease-free after multimodality care

Patient Info: Anonymized, transgender man, 70+ | Stage III

Biomarkers: HER2-positive invasive lobular breast cancer, ER/PR negative

Nearly 2 years after diagnosis, he remained disease-free while continuing survivorship care and counseling after discontinuing testosterone therapy.

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Stage III Ovarian Cancer: Shelly's Patient Story

Patient Info: Shelly Sepulveda, Female, 40s | Stage III

Living with recurrent ovarian cancer and receiving weekly intravenous chemotherapy after a brief remission.

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Rare soft-tissue sarcoma: surgery and multimodal treatment

Patient Info: Anonymized, Female, 60s | Stage IV

Biomarkers: Pathogenic BRIP1 c.1871C>A mutation found in tumor and germline testing; vimentin positive, SMARCB1/SMARCA4 preserved.

Metastatic Site: lung, left hilar lymph node

As of September 2025, she had sustained complete oncologic remission for 36 months after starting olaparib 300 mg twice daily for BRIP1-mutated metastatic undifferentiated pleomorphic sarcoma.

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Stage IV BRAF Colorectal Cancer: Jackson's Patient Story

Patient Info: Jackson, Male, Under 40 | Stage IV

Biomarkers: BRAF mutation

Metastatic Site: Liver; peritoneal wall

Jackson had Stage IV BRAF-mutated colon cancer with extensive liver disease and later confirmed peritoneal-wall tumors. His treatment response was strong, with about 90% of liver disease estimated gone, but he remained on active treatment with possible future HIPEC evaluation. As of September 2025, he was responding well but not cancer-free.

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Stage IV Colorectal Cancer: Laura's Patient Story

Patient Info: Laura VanBrocklin, 40s | Stage IV

Metastatic Site: liver

After multiple procedures and surgery for Stage IV colorectal cancer with liver involvement, Laura was still finishing chemotherapy.

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Triple-negative breast pleomorphic adenocarcinoma: disease-free after mastectomy and one course of capecitabine

Patient Info: Anonymized, Female, 70+

Biomarkers: Triple-negative breast pleomorphic adenocarcinoma with PIK3CA mutation; markers supported the diagnosis.

As of September 2025, she had 2 years of disease-free survival after left total mastectomy, sentinel lymph node exploration, and 1 course of oral capecitabine.

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