Stage IV Colorectal Cancer: Cora's Patient Story

Patient Info: Cora, Female | Stage IV

Metastatic Site: Liver; lungs

As of February 2026, Cora had recurrent Stage IV colorectal cancer with a positive ctDNA test but clear CT imaging after stopping an immunotherapy trial because of toxicity, so ongoing care and monitoring were still needed.

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Stage 4 breast cancer: 4 years and counting

Patient Info: Anonymized, Female, 60s | Stage IV

Biomarkers: Initial tumor: hormone receptor-positive; HER2 1+. Metastatic recurrence: triple-negative breast cancer.

Metastatic Site: liver, bone, lung, supraclavicular lymph nodes,…

After response of choroidal metastases to eye radiation plus sacituzumab govitecan, disease progressed in February 2023 with cerebellar and pituitary brain lesions; she developed obstructive hydrocephalus, entered hospice in May 2023, and died in June 2023.

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Male idiopathic granulomatous mastitis mimicking breast cancer

Patient Info: Anonymized, Male, 60s

Biomarkers: Granulomatous mastitis: CD68 positive and keratin AE1/AE3 negative; infectious tests and stains were negative.

The breast lesion was excised and confirmed to be granulomatous mastitis rather than cancer; at 1-year postoperative ultrasound, there was no recurrence or residual lesion.

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Large-Cell Neuroendocrine Cancer of the Cecum in Familial Adenomatous Polyposis

Patient Info: Anonymized, female

Biomarkers: Pathogenic germline APC mutation; KRAS ; PALB2 mutation; microsatellite stable with intact mismatch-repair proteins

At 18 months after the initial right colectomy, there was no pathologic, clinical, or imaging evidence of recurrence.

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Stage IIIB triple-negative metaplastic breast cancer: urgent mastectomy and reconstruction after rapid progression on neoadjuvant therapy

Patient Info: Anonymized, Female, 40s | Stage III

Biomarkers: ER-negative; PR-negative; HER2-negative; nuclear grade 3

At 18-month follow-up, she was disease-free after urgent mastectomy, axillary dissection, flap/skin-graft reconstruction, resumed chemotherapy, and radiation for rapidly progressive triple-negative metaplastic breast cancer.

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Lung Cancer Treated With Sleeve Right Lower Lobectomy in COPD

Patient Info: Anonymized, male | Stage II

He remained disease-free through 28 months of follow-up.

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Stage IIB breast cancer with severe radiation recall after abemaciclib

Patient Info: Anonymized, Female, 40s

Biomarkers: ER-positive; PR-positive; HER2 1+ / HER2-negative

The flap healed after abemaciclib was stopped and the tissue expander/patch were removed, but her long-term cancer-control and reconstruction outcomes were not yet reported.

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Lung Cancer Treated With Sleeve Right Lower Lobectomy in COPD — Case 2

Patient Info: Anonymized, male | Stage I

He remained disease-free through 26 months of follow-up.

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Lung Cancer Treated With Sleeve Right Lower Lobectomy in COPD — Case 3

Patient Info: Anonymized, male | Stage II

He remained disease-free through 30 months of follow-up.

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Lung Cancer Treated With Sleeve Right Lower Lobectomy in COPD — Case 4

Patient Info: Anonymized, male | Stage II

He had no lung-cancer recurrence and died from a cerebral hemorrhage 51 months after surgery.

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Early lung adenocarcinoma found on screening with surgical recovery after tamponade complication

Patient Info: Anonymized, Male, 60s | Stage I

The Stage I lung adenocarcinoma was removed by wedge resection with clear margins. A life-threatening postoperative cardiac tamponade was successfully treated, and the patient was discharged on postoperative day 19 with full recovery.

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Stage IV Colorectal Cancer: Nina's Survivor Story

Patient Info: Nina, Female | Stage IV

Metastatic Site: ovaries; liver

After initial Stage IV bowel cancer with spread to the ovaries and liver, surgery and chemotherapy led to no evidence of disease; she continued with regular checkups and emotional recovery.

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Stage IV ALK Lung Cancer: Ruchira's Survivor Story

Patient Info: Ruchira, Female | Stage IV

Biomarkers: ALK-positive

Metastatic Site: Not reported

Although the disease progressed to Stage IV after lobectomy, ALK testing led to lorlatinib; she reported no evidence of disease after 3 months and continued daily targeted therapy.

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Localized male small-cell neuroendocrine breast cancer with complete response

Patient Info: Anonymized, Male, 40s

Biomarkers: Synaptophysin-positive; weak cytokeratin-positive; HER2-negative; Ki-67 greater than 70%; genetic testing not performed

The tumor shrank substantially during neoadjuvant cisplatin/etoposide. Modified radical mastectomy then showed a complete pathologic response and 17 reactive axillary lymph nodes; the patient remained disease-free after 18 months of follow-up.

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EGFR-mutant lung adenocarcinoma with acquired ROS1 rearrangement after EGFR-TKI resistance

Patient Info: Anonymized, Female, 50s | Stage IV

Biomarkers: EGFR exon 19 deletion; acquired EGFR T790M; acquired EZR exon10-ROS1 exon34 rearrangement

Metastatic Site: bone (distal femur); contralateral lung;…

After fourth-line crizotinib for acquired EZR-ROS1 rearrangement, response evaluation on August 27, 2025 showed partial response, and September 2025 bone scan showed stable bone lesions.

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Metastatic triple-negative breast cancer with sacituzumab-govitecan pneumonitis and progression

Patient Info: Anonymized, Female, 60s | Stage IV

Biomarkers: ER-negative; PR-negative; HER2-negative

Metastatic Site: lung

Sacituzumab-govitecan pneumonitis improved with corticosteroids and half-dose rechallenge did not reproduce pneumonitis, but follow-up CT showed one new pulmonary metastasis and enlargement of previous lung metastases; PFS on sacituzumab govitecan was 5.37 months.

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Stage II Triple-Negative Breast Cancer: Chase's Survivor Story

Patient Info: Chase, Female, Under 40 | Stage II

Biomarkers: ER-negative; PR-negative; HER2-negative

As of January 2026, Chase had shown no evidence of cancer for nearly 5 years after Stage IIB triple-negative breast cancer treatment and had completed 3 investigational vaccine injections without significant side effects.

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Stage II Invasive Lobular Carcinoma: Tamra's Patient Story

Patient Info: Tamra, Female | Stage II

Biomarkers: MammaPrint genomic analysis pending/under consideration

As of January 2026, Tamra had chosen partial mastectomy with radiation and concurrent bilateral reconstruction for Stage II invasive lobular breast cancer, with chemotherapy decision dependent on MammaPrint results.

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Stage IV Colorectal Cancer: Kina's Survivor Story

Patient Info: Kina, Female | Stage IV

Metastatic Site: Lungs; lymph node

As of January 2026, Kina described herself as technically having no cancer/no evidence of disease after lung resections, though confirmatory CT was still pending and she was still recovering from complications.

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Breast cancer survivor developed Ramsay Hunt syndrome with vertigo

Patient Info: Anonymized, Female, 60s

Biomarkers: Breast cancer biomarkers not reported. Ramsay Hunt syndrome was diagnosed clinically.

Breast cancer treatment had been completed years earlier. The later neurological episode improved partially after antiviral therapy, steroids, pain control, betahistine, acupuncture, and vestibular rehabilitation, with mild residual dizziness and facial weakness at 3 months.

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Lynch-associated lung and colorectal cancers responded to immunotherapy

Patient Info: Anonymized, Female, 50s | Stage IV

Biomarkers: dMMR/MSI-H pattern with MLH1/PMS2 loss and germline MLH1 mutation; KRAS and PTEN mutations; PD-L1 TPS 15%.

Metastatic Site: right paraspinal metastatic lesion from lung…

After starting iparomlimab plus tuvonralimab, pleural and pelvic disease improved, intestinal wall involvement decreased further after 5 cycles, the paraspinal lung metastasis remained stable, tumor markers stayed normal, and treatment continued.

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Stage IV HER2-Positive Breast Cancer: Sonja's Patient Story

Patient Info: Sonja Rideout, Female | Stage IV

Biomarkers: HER2-positive; Tempus testing later indicated immunotherapy as an option

Metastatic Site: Lungs; liver; bone: tailbone; thoracic lymph nodes

As of January 2026, Sonja was living with metastatic HER2-positive breast cancer after spread to lungs and liver, later tailbone and thoracic lymph nodes, and had moved to weekly carboplatin/gemcitabine plus monthly immunotherapy.

Stage IV Colorectal Cancer: Kristie's Patient Story

Patient Info: Kristie, Female, 50s | Stage IV

Metastatic Site: liver

Kristie is living with Stage IV colon cancer with liver recurrence, prior chemotherapy/radiation/surgery/ablation, and a planned liver resection option after second-opinion review.

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Stage IV triple-negative invasive lobular breast cancer with HER2 mutations: complete metabolic response to trastuzumab deruxtecan

Patient Info: Anonymized, Female, 70+ | Stage IV

Biomarkers: Triple-negative invasive lobular breast cancer with HER2-low/dubious staining and HER2 FISH-negative; somatic ERBB2/HER2 and mutations.

Metastatic Site: iliac bone lesions / bone metastases

As of January 2026, metastatic triple-negative invasive lobular breast cancer with HER2 mutations had a sustained complete metabolic response to trastuzumab deruxtecan for 20 months, with dose reduction for neutropenia and no pulmonary toxicity.

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